3-bromo-4-(2-methoxy-ethylamino)-5-(morpholine-4-sulfonyl)-benzaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-bromo-4-(2-methoxy-ethylamino)-5-(morpholine-4-sulfonyl)-benzaldehyde
• 英文别名: 3-Bromo-4-(2-methoxy-ethylamino)-5-(morpholine-4-sulfonyl)-benzaldehyde；3-bromo-4-(2-methoxyethylamino)-5-morpholin-4-ylsulfonylbenzaldehyde
• 化学式: C₁₄H₁₉BrN₂O₅S
• 分子量: 407.285
• InChiKey: RGQLQWWFVYYSMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  93.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-bromo-4-(2-methoxy-ethylamino)-5-(morpholine-4-sulfonyl)-benzaldehyde 、 3-氨基巴豆腈 、 5-丙基-1,3-环己烷二酮 以 乙醇 为溶剂， 反应 17.0h， 生成 4-[3-bromo-4-(2-methoxy-ethylamino)-5-(morpholine-4-sulfonyl)-phenyl]-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile
  参考文献：
  名称：

  WO2006/117371

  摘要：

  公开号：
• 作为产物：
  描述：

  在 manganese(IV) oxide 作用下， 以 四氢呋喃 为溶剂， 生成 3-bromo-4-(2-methoxy-ethylamino)-5-(morpholine-4-sulfonyl)-benzaldehyde
  参考文献：
  名称：

  WO2006/117371

  摘要：

  公开号：

文献信息

• 4-Phenyl-5-Oxo-1,4,5,6,7,8- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility
  申请人：Karstens Willem Frederik Johan

  公开号：US20080262033A1

  公开（公告）日：2008-10-23

  The present invention- relates to 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives having the general Formula (I) wherein the substituents are defined as in the description, or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, as well as to the use of these 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives in therapy, more specifically for the treatment of fertility disorders.

  本发明涉及具有通式（I）的2-甲基-4-苯基-5-氧代-1,4,5,6,7,8-六氢喹啉衍生物，其中取代基如描述中所定义，或其药学上可接受的盐。本发明还涉及包含所述衍生物的制药组合物，以及利用这些2-甲基-4-苯基-5-氧代-1,4,5,6,7,8-六氢喹啉衍生物治疗生育障碍的用途。
• 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives as medicaments for the treatment of infertility
  申请人：N.V. Organon

  公开号：US08017782B2

  公开（公告）日：2011-09-13

  The present invention relates to 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives having the general Formula (I) wherein the substituents are defined as in the description, or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, as well as to the use of these 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives in therapy, more specifically for the treatment of fertility disorders.

  本发明涉及具有一般式（I）的2-甲基-4-苯基-5-氧代-1,4,5,6,7,8-六氢喹啉衍生物，其中取代基如描述中所定义，或其药学上可接受的盐。本发明还涉及包含所述衍生物的制药组合物，以及使用这些2-甲基-4-苯基-5-氧代-1,4,5,6,7,8-六氢喹啉衍生物在治疗中的用途，更具体地用于治疗生育障碍。
• 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QËIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
  申请人：N.V. Organon

  公开号：EP1879581A1

  公开（公告）日：2008-01-23
• US8017782B2
  申请人：——

  公开号：US8017782B2

  公开（公告）日：2011-09-13
• [EN] 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QËIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY<br/>[FR] DERIVES DE 2-METHYL-4-PHENYL-5-OXO-1,4,5,6,7,8-HEXAHYDROQUINOLINE SERVANT DE MEDICAMENTS POUR TRAITER L'INFERTILITE
  申请人：ORGANON NV

  公开号：WO2006117371A1

  公开（公告）日：2006-11-09

  [EN] The present invention- relates to 2-methyl-4-phenyl-5-oxo-1 ,4,5,6,7,8-hexahydroquinoline derivatives having the general Formula (I) wherein the substituents are defined as in the description, or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, as well as to the use of these 2-methyl-4-phenyl-5-oxo-1 ,4,5,6,7,8-hexahydroquinoline derivatives in therapy, more specifically for the treatment of fertility disorders.
  [FR] L'invention concerne un dérivé de 2-méthyl-4-phényl-5-oxo-1,4,5,6,7,8-hexahydroquinoline de formule (I). Dans cette formule, les substituants sont définis dans la description. L'invention concerne également un sel pharmaceutiquement acceptable de ces dérivés. L'invention concerne encore des compositions pharmaceutiques comprenant ces dérivés et l'utilisation de ses dérivés en thérapie, en particulier pour traiter des troubles de stérilité.