4,8-二氯-1,7-萘啶 | 1279894-03-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 4,8-二氯-1,7-萘啶
• 英文名称: 4,8-dichloro-1,7-naphthyridine
• CAS: 1279894-03-9
• 化学式: C₈H₄Cl₂N₂
• 分子量: 199.039
• InChiKey: WHJPXKCFKJMNKT-UHFFFAOYSA-N

物化性质

• 沸点：
  324.9±37.0 °C(Predicted)
• 密度：
  1.486±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  4,8-二氯-1,7-萘啶 在 potassium phosphate 、 tris-(dibenzylideneacetone)dipalladium(0) 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium carbonate 、 三环己基膦 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 反应 17.0h， 生成 ethyl 2-(2-((5-(8-amino-1,7-naphthyridin-4-yl)-1-isopropyl-1H-indazol-3-yl)methoxy)phenyl)acetate
  参考文献：
  名称：

  [EN] BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5
  [FR] INHIBITEURS HÉTÉROAROMATIQUES BICYCLIQUES DE LA KLK5

  摘要：

  本发明涉及式(I)-(IV)的化合物及其药学上可接受的盐，这些化合物是卡利肯酶相关肽酶5（KLK5）的抑制剂。还提供了包含这种化合物的制药组合物以及使用这些化合物和组合物治疗或预防由异常KLK5活性引起的疾病或病状的方法，例如Netherton综合症。

  公开号：

  WO2022221526A1

文献信息

• HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
  申请人：Incyte Corporation

  公开号：US20170174679A1

  公开（公告）日：2017-06-22

  Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

  揭示了Formula (I′)的化合物，使用这些化合物作为免疫调节剂的方法，以及包含这些化合物的药物组合物。这些化合物在治疗、预防或改善癌症或感染等疾病或障碍方面是有用的。
• Hydrophilic treatment coating composition and hydrophilizing treatment method
  申请人：Lixil Corporation

  公开号：US10563067B2

  公开（公告）日：2020-02-18

  Provided are (1) a hydrophilic treatment coating composition containing a compound that contains a radical reactive functional group and a sulfonic acid alkali metal salt group, a radical polymerization initiator, and a polar compatibilizer, (2) a hydrophilic treatment coating composition containing a silane coupling agent that contains a radical reactive functional group, a compound that contains a radical reactive functional group and a sulfonic acid alkali metal salt group, a radical polymerization initiator, and a polar compatibilizer, (3) a hydrophilic treatment coating composition containing a compound that contains a functional group that reacts with a reactive functional group of a silane coupling agent in a surface layer, and a sulfonic acid (alkali metal salt) group, and a polar compatibilizer, and (4) a hydrophilic treatment coating composition containing a silane coupling agent that contains a reactive functional group, a compound that contains a functional group that reacts with the reactive functional group and a sulfonic acid (alkali metal salt) group, and a polar compatibilizer.

  提供了 (1) 一种亲水处理涂层组合物，其中含有一种含有自由基活性官能团和磺酸碱金属盐基的化合物、一种自由基聚合引发剂和一种极性相容剂；(2) 一种亲水处理涂层组合物，其中含有一种含有自由基活性官能团的硅烷偶联剂、一种含有自由基活性官能团和磺酸碱金属盐基的化合物、一种自由基聚合引发剂和一种极性相容剂、(3) 一种亲水处理涂层组合物，其中含有一种化合物，该化合物含有一个与表层硅烷偶联剂的反应性官能团反应的官能团、一个磺酸（碱金属盐）基团和一种极性相容剂；以及 (4) 一种亲水处理涂层组合物，其中含有一种硅烷偶联剂，该偶联剂含有一个反应性官能团、一个与反应性官能团反应的官能团和一个磺酸（碱金属盐）基团的化合物，以及一种极性相容剂。
• Heterocyclic compounds as immunomodulators
  申请人：Incyte Corporation

  公开号：US11535615B2

  公开（公告）日：2022-12-27

  Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

  本发明公开了式(I′)化合物、使用这些化合物作为免疫调节剂的方法以及包含这些化合物的药物组合物。这些化合物可用于治疗、预防或改善癌症或感染等疾病或紊乱。
• HYDROPHILIC TREATMENT COATING COMPOSITION AND HYDROPHILIZING TREATMENT METHOD
  申请人：Lixil Corporation

  公开号：US20170174901A1

  公开（公告）日：2017-06-22

  Provided are (1) a hydrophilic treatment coating composition containing a compound that contains a radical reactive functional group and a sulfonic acid alkali metal salt group, a radical polymerization initiator, and a polar compatibilizer, (2) a hydrophilic treatment coating composition containing a silane coupling agent that contains a radical reactive functional group, a compound that contains a radical reactive functional group and a sulfonic acid alkali metal salt group, a radical polymerization initiator, and a polar compatibilizer, (3) a hydrophilic treatment coating composition containing a compound that contains a functional group that reacts with a reactive functional group of a silane coupling agent in a surface layer, and a sulfonic acid (alkali metal salt) group, and a polar compatibilizer, and (4) a hydrophilic treatment coating composition containing a silane coupling agent that contains a reactive functional group, a compound that contains a functional group that reacts with the reactive functional group and a sulfonic acid (alkali metal salt) group, and a polar compatibilizer.
• [EN] HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES UTILISÉS COMME IMMUNOMODULATEURS
  申请人：INCYTE CORP

  公开号：WO2017112730A1

  公开（公告）日：2017-06-29

  Disclosed are compounds of Formula (I'), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.