4,8-二氯-1,5-萘啶 | 28252-80-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 4,8-二氯-1,5-萘啶
• 英文名称: 4,8-Dichlor-1,5-naphthyridin
• 英文别名: 4,8-Dichloro-1,5-naphthyridine
• CAS: 28252-80-4
• 化学式: C₈H₄Cl₂N₂
• 分子量: 199.039
• InChiKey: SQLGCTFYLAMNAC-UHFFFAOYSA-N

物化性质

• 熔点：
  274-276℃
• 沸点：
  289.0±35.0 °C(Predicted)
• 密度：
  1.486±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  4,8-二氯-1,5-萘啶 在 四(三苯基膦)钯 、 palladium diacetate 、 potassium carbonate 、 联硼酸频那醇酯 、 sodium t-butanolate 、 tri tert-butylphosphoniumtetrafluoroborate 作用下， 以 水 、 甲苯 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  一种荧光材料、制备方法及应用

  摘要：

  本发明公开了一种荧光材料、制备方法及应用，其中，荧光材其中，R1～R10各自独立地选自H原子、氘原子、给电子基团或拉电子基团中的一种；并且R1～R10中至少有一个是给电子基团，至少有一个是拉电子基团。本发明提供的荧光材料，具有扭曲的D‑A结构，两个萘啶受体直接相连，构成双发射体分子，可以增加空间位阻，从而增加光致发光量子产率，提高电致发光器件的发光效率。另外本材料同时具有热活化延迟荧光和聚集诱导发光特性，既可以实现100％的内量子效率，又能减少聚集导致的发光猝灭过程。将这些材料用于有机电致发光器件中时，其效率可与磷光相媲美，且避免了现有的磷光材料通常要使用重金属铱、铂等昂贵的重金属的问题。

  公开号：

  CN109913205B
• 作为产物：
  描述：

  4,8-二氯喹啉-3-羧酸乙酯 在 氢溴酸 、 三氯氧磷 作用下， 反应 52.0h， 生成 4,8-二氯-1,5-萘啶
  参考文献：
  名称：

  Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action

  摘要：

  Ebola virus (EBOV) causes a deadly hemorrhagic fever in humans and non-human primates. There is currently no FDA-approved vaccine or medication to counter this disease. Here, we report on the design, synthesis and anti-viral activities of two classes of compounds which show high potency against EBOV in both in vitro cell culture assays and in vivo mouse models Ebola viral disease. These compounds incorporate the structural features of cationic amphiphilic drugs (CAD), i.e they possess both a hydrophobic domain and a hydrophilic domain consisting of an ionizable amine functional group. These structural features enable easily diffusion into cells but once inside an acidic compartment their amine groups became protonated, ionized and remain trapped inside the acidic compartments such as late endosomes and lysosomes. These compounds, by virtue of their lysomotrophic functions, blocked EBOV entry. However, unlike other drugs containing a CAD moiety including chloroquine and amodiaquine, compounds reported in this study display faster kinetics of accumulation in the lysosomes, robust expansion of late endosome/lysosomes, relatively more potent suppression of lysosome fusion with other vesicular compartments and inhibition of cathepsins activities, all of which play a vital role in anti-EBOV activity. Furthermore, the diazachrysene 2 (ZSML08) that showed most potent activity against EBOV in in vitro cell culture assays also showed significant survival benefit with 100% protection in mouse models of Ebola virus disease, at a low dose of 10 mg/kg/day. Lastly, toxicity studies in vivo using zebrafish models suggest no developmental defects or toxicity associated with these compounds. Overall, these studies describe two new pharmacophores that by virtue of being potent lysosomotrophs, display potent anti-EBOV activities both in vitro and in vivo animal models of EBOV disease. (C) 2018 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2018.10.061

文献信息

• [EN] NITROGEN-CONTAINING AROMATIC COMPOUNDS AND METAL COMPLEXES<br/>[FR] COMPOSÉS AROMATIQUES COMPRENANT DE L'AZOTE ET COMPLEXES MÉTALLIQUES
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2011052805A1

  公开（公告）日：2011-05-05

  To provide nitrogen-containing aromatic compounds with excellent oxygen reduction activity, metal complexes containing them, and catalysts and electrodes employing the same, the present invention provides an aromatic compound satisfying the following conditions (a) and (b): (a) It has 2 or more structures surrounded by at least 4 coordinatable nitrogen atoms (which structures may be the same or different), (b) At least one of the nitrogen atoms composing the structure is a nitrogen atom in a 6-membered nitrogen-containing heterocyclic ring.

  为了提供具有优异氧还原活性的含氮芳香化合物，含有它们的金属配合物，以及使用相同金属配合物的催化剂和电极，本发明提供了满足以下条件（a）和（b）的芳香化合物：（a）它具有至少4个可配位氮原子包围的2个或更多结构（这些结构可以相同也可以不同），（b）构成结构的氮原子中至少有一个是6元氮含杂环的氮原子。
• CATHODE CATALYST FOR AIR SECONDARY BATTERY AND AIR SECONDARY BATTERY
  申请人：Koshino Nobuyoshi

  公开号：US20140066290A1

  公开（公告）日：2014-03-06

  The present invention provides a cathode catalyst for an air secondary cell having both excellent oxygen reduction activity and excellent water oxidation activity, and an air secondary cell that uses the catalyst. The present invention relates to a cathode catalyst for an air secondary cell in which the catalyst contains a polynuclear metal complex.

  本发明提供了一种空气二次电池的阴极催化剂，具有优异的氧还原活性和优异的水氧化活性，并且使用该催化剂的空气二次电池。本发明涉及一种空气二次电池的阴极催化剂，其中该催化剂包含多核金属配合物。
• Nitrogen-containing aromatic compounds and metal complexes
  申请人：Koshino Nobuyoshi

  公开号：US10392395B2

  公开（公告）日：2019-08-27

  To provide nitrogen-containing aromatic compounds with excellent oxygen reduction activity, metal complexes containing them, and catalysts and electrodes employing the same, the present invention provides an aromatic compound satisfying the following conditions (a) and (b): (a) It has 2 or more structures surrounded by at least 4 coordinatable nitrogen atoms (which structures may be the same or different), (b) At least one of the nitrogen atoms composing the structure is a nitrogen atom in a 6-membered nitrogen-containing heterocyclic ring.

  为了提供具有优异氧还原活性的含氮芳香族化合物、含有它们的金属络合物以及使用它们的催化剂和电极，本发明提供了一种满足以下条件（a）和（b）的芳香族化合物： (a) 具有 2 个或 2 个以上由至少 4 个可配位氮原子包围的结构（这些结构可以相同或 不同）、 (b) 构成该结构的氮原子中至少有一个是 6 元含氮杂环中的氮原子。
• BROWN S. B.; DEWAR M. J. S., J. ORG. CHEM. 1978, 43, NO 7, 1331-1337
  作者：BROWN S. B.、 DEWAR M. J. S.

  DOI：——

  日期：——
• PHENYLUREA AND PHENYLTHIO UREA DERIVATIVES
  申请人：SmithKline Beecham plc

  公开号：EP1075478B1

  公开（公告）日：2003-04-16