2-methylsulfonyl-5-benzyl-1,3,4-oxadiazole | 23767-42-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methylsulfonyl-5-benzyl-1,3,4-oxadiazole
• 英文别名: 2-Benzyl-5-methylsulfonyl-1,3,4-oxadiazole；2-benzyl-5-methylsulfonyl-1,3,4-oxadiazole
• CAS: 23767-42-2
• 化学式: C₁₀H₁₀N₂O₃S
• 分子量: 238.267
• InChiKey: ZLTIQBGBILLHMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-methylsulfonyl-5-benzyl-1,3,4-oxadiazole 、 邻氨基苯甲酸甲酯 以 溶剂黄146 为溶剂， 生成 2-benzyl-[1,3,4]oxadiazolo[2,3-b]quinazolin-5-one
  参考文献：
  名称：

  Vakula,T.R. et al., Journal fur praktische Chemie (Leipzig 1954), 1973, vol. 315, p. 185 - 188

  摘要：

  DOI：
• 作为产物：
  描述：

  5-苄基-[1,3,4]噁二唑-2-硫醇 在 potassium permanganate 、 溶剂黄146 作用下， 生成 2-methylsulfonyl-5-benzyl-1,3,4-oxadiazole
  参考文献：
  名称：

  Madhavan,R.; Srinivasan,V.R., Indian Journal of Chemistry, 1969, vol. 7, p. 760 - 765

  摘要：

  DOI：

文献信息

• 一类防治香蕉根线虫的硫醚砜类化合物及其制备方法和应用
  申请人：贵州大学

  公开号：CN109705054A

  公开（公告）日：2019-05-03

  本发明涉及一类防治香蕉根线虫的硫醚砜类化合物及其制备方法和应用，其可制备成各种农业上常规的剂型。所述化合物及其衍生物可有效防治香蕉根线虫。
• Madhavan,R.; Srinivasan,V.R., Indian Journal of Chemistry, 1969, vol. 7, p. 760 - 765
  作者：Madhavan,R.、Srinivasan,V.R.

  DOI：——

  日期：——
• Design, synthesis, and antibacterial activity against rice bacterial leaf blight and leaf streak of 2,5-substituted-1,3,4-oxadiazole/thiadiazole sulfone derivative
  作者：Pei Li、Li Shi、Xia Yang、Lei Yang、Xue-Wen Chen、Fang Wu、Qing-Cai Shi、Wei-Ming Xu、Ming He、De-Yu Hu、Bao-An Song

  DOI：10.1016/j.bmcl.2014.02.060

  日期：2014.4

  A series of 2,5-substituted-1,3,4-oxadiazole/thiadiazole sulfone derivatives were synthesized and evaluated for their antibacterial activities against rice bacterial leaf blight and leaf streak caused by Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicolaby via the turbidimeter test in vitro. Antibacterial bioassay results indicated that most compounds demonstrated good inhibitory effect antibacterial bioactivities against rice bacterial leaf blight and leaf streak. Among the title compounds, compound 6c demonstrated the best inhibitory effect against rice bacterial leaf blight and leaf streak with half-maximal effective concentration (EC50)values of 1.07 and 7.14 mu g/mL, respectively, which were even better than those of commercial agents such as Bismerthiazol and Thiediazole Copper. In vivo antibacterial activities tests at greenhouse conditions demonstrated that the controlling effect of compounds 6c (43.5%) and 6g (42.4%) against rice bacterial leaf blight were better than those of Bismerthiazol (25.5%) and Thiediazole Copper (37.5%). (C) 2014 Elsevier Ltd. All rights reserved.
• Vakula,T.R. et al., Journal fur praktische Chemie (Leipzig 1954), 1973, vol. 315, p. 185 - 188
  作者：Vakula,T.R. et al.

  DOI：——

  日期：——