N-(4-phenoxy-phenyl)-3-{3-[4-(3,4,5-trimethoxy-phenylamino)-[1,3,5]triazin-2-yl]-pyridin-2-ylamino}-benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-phenoxy-phenyl)-3-{3-[4-(3,4,5-trimethoxy-phenylamino)-[1,3,5]triazin-2-yl]-pyridin-2-ylamino}-benzamide
• 英文别名: N-(4-phenoxy-phenyl)-3-{3-[4-(3,4,5-trimethoxy-phenylamino)-[1,3,5]triazin-2-yl]-pyridin-2-ylamino}benzamide；N-(4-phenoxyphenyl)-3-[[3-[4-(3,4,5-trimethoxyanilino)-1,3,5-triazin-2-yl]pyridin-2-yl]amino]benzamide
• 化学式: C₃₆H₃₁N₇O₅
• 分子量: 641.686
• InChiKey: BRXKGRHLVVRORC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  48
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  2-chloro-4-(2-chloropyridin-3-yl)-[1,3,5]triazine 在 三乙胺 作用下， 以 二甲基亚砜 、 异丙醇 为溶剂， 反应 48.0h， 生成 N-(4-phenoxy-phenyl)-3-{3-[4-(3,4,5-trimethoxy-phenylamino)-[1,3,5]triazin-2-yl]-pyridin-2-ylamino}-benzamide
  参考文献：
  名称：

  Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor

  摘要：

  Inhibition of angiogenesis is a promising and clinically validated approach for limiting tumor growth and survival. The receptor tyrosine kinase Tie-2 is expressed almost exclusively in the vascular endothelium and is required for developmental angiogenesis and vessel maturation. However, the significance of Tie-2 signaling in tumor angiogenesis is not well understood. In order to evaluate the therapeutic utility of inhibiting Tie-2 signaling, we developed a series of potent and orally bioavailable small molecule Tie-2 kinase inhibitors with selectivity over other kinases, especially those that are believed to be important for tumor angiogenesis. Our earlier work provided pyridinyl pyrimidine 6 as a potent, nonselective Tie-2 inhibitor that was designed on the basis of X-ray cocrystal structures of KDR inhibitors 34 (triazine) and 35 (nicotinamide). Lead optimization resulted in pyridinyl triazine 63, which exhibited > 30-fold selectivity over a panel of kinases, good oral exposure, and in vivo inhibition of Tie-2 phosphorylation.

  DOI：

  10.1021/jm061107l

文献信息

• Substituted triazinyl amide derivatives and methods of use
  申请人：——

  公开号：US20030087908A1

  公开（公告）日：2003-05-08

  The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer and angiogenesis-related disease.

  本发明包括化合物、类似物、前药及其药物可接受的盐，药物组合物，以及用于预防与治疗癌症和与血管生成相关疾病的用途和方法。
• Alpha-arylethylpiperazine derivatives as neurokinin antagonists
  申请人：——

  公开号：US20030220323A1

  公开（公告）日：2003-11-27

  The invention relates to new &agr;-arylethylpiperazine derivatives, which are useful as neurokinin receptor antagonists (NK 1 antagonists). It also relates to processes for the preparation of said &agr;-arylethylpiperazine derivatives, to their use for the prevention and/or treatment of a condition associated with pathogical levels of substance P in a patient and to pharmaceutical compositions containing them.

  本发明涉及新的α-芳基乙基哌嗪衍生物，其可用作神经激肽受体拮抗剂（NK1拮抗剂）。它还涉及制备所述α-芳基乙基哌嗪衍生物的方法，以及它们在预防和/或治疗患者中与物质P的病理水平相关的疾病和含有它们的制药组合物的用途。
• $g(a)-ARYLETHYLPIPERAZINE DERIVATIVES AS NEUROKININ ANTAGONISTS
  申请人：UCB S.A.

  公开号：EP1242399A1

  公开（公告）日：2002-09-25
• EP1385833A1
  申请人：——

  公开号：EP1385833A1

  公开（公告）日：2004-02-04
• US6864255B2
  申请人：——

  公开号：US6864255B2

  公开（公告）日：2005-03-08