1-(2,4,6-trifluorophenyl)propan-2-one | 835878-82-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,4,6-trifluorophenyl)propan-2-one
• 英文别名: 1-(2,4,6-trifluorophenyl)-2-propanone
• CAS: 835878-82-5
• 化学式: C₉H₇F₃O
• mdl: MFCD11553530
• 分子量: 188.149
• InChiKey: NAKZSJUHEAAUHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2,4,6-trifluorophenyl)propan-2-one 、 3,5-二甲氧基苯甲醛 在 溶剂黄146 哌啶 作用下， 以 甲苯 为溶剂， 生成 4-(3,5-dimethoxyphenyl)-3-(2,4,6-trifluorophenyl)-3-buten-2-one
  参考文献：
  名称：

  [EN] FUNGICIDAL PYRIDINES
  [FR] PYRIDINES FONGICIDES

  摘要：

  公开号：

  WO2009158257A4
• 作为产物：
  描述：

  1,3,5-三氟-2-(2-硝基丙-1-烯基)苯 在 盐酸 、 iron(III) chloride 、 水 作用下， 反应 7.0h， 生成 1-(2,4,6-trifluorophenyl)propan-2-one
  参考文献：
  名称：

  PYRIDAZINE COMPOUND AND USE THEREOF

  摘要：

  公开号：

  EP1775290B1

文献信息

• [EN] GLYCINE B ANTAGONISTS<br/>[FR] ANTAGONISTES DE LA GLYCINE B
  申请人：MERZ PHARMA GMBH & CO KGAA

  公开号：WO2012164085A1

  公开（公告）日：2012-12-06

  The invention relates to 2(1H)-quinolinone derivatives of formula (I) as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are glycine B antagonists and are therefore useful for the control and prevention of various disorders, including neurological disorders.

  该发明涉及公式（I）的2（1H）-喹啉酮衍生物及其药用可接受的盐。该发明还涉及一种制备此类化合物的方法。该发明的化合物是甘氨酸B拮抗剂，因此对于控制和预防各种疾病，包括神经系统疾病，具有用途。
• NOVEL LINEAR ALPHA-OLEFIN CATALYSTS AND PREPARATION AND USE THEREOF
  申请人：APALENE TECHNOLOGY CO., LTD. (JIAXING)

  公开号：US20180147571A1

  公开（公告）日：2018-05-31

  The present invention relates to a novel linear a-olefin catalyst composition, and preparation and use thereof. The catalyst composition includes a main catalyst and a co-catalyst, wherein the main catalyst is an imino-based iron coordination compound, and the co-catalyst is a mixture of methylaluminoxane, triisobutylaluminum, and borane or GaCl 3 . The catalyst composition can be used to catalyze ethylene oligomerization to produce linear α-olefins having a selectivity of greater than 96%, carbon distribution between C4-C28 with the component of C6-C20 being greater than 75%. The catalyst of the invention is stable in structure and can be used for ethylene oligomerization with high catalytic efficiency. The method of the invention has the advantages of relatively convenient in operation, readily available of raw materials, high yield, low costs, less pollution and easy for industrial production.

  本发明涉及一种新型的线性α-烯烃催化剂组合物，以及其制备和使用。该催化剂组合物包括主催化剂和辅助催化剂，其中主催化剂是一种基于亚胺的铁配位化合物，而辅助催化剂是甲基铝氧烷、三异丁基铝和硼烷或氯化镓的混合物。该催化剂组合物可用于催化乙烯寡聚反应，产生选择性大于96%的线性α-烯烃，碳分布在C4-C28之间，其中C6-C20的组分大于75%。该发明的催化剂结构稳定，可用于高效乙烯寡聚反应。该发明的方法具有操作相对便利、原料易得、产量高、成本低、污染少且易于工业生产的优点。
• Aryl-condensed 3-arylpridine compounds and use thereof for controlling pathogenic fungi
  申请人：Wagner Oliver

  公开号：US20060160811A1

  公开（公告）日：2006-07-20

  The present invention relates to bicyclic compounds of general formula I, in which X, Y independently of one another are N or C—R 4 ; n is 1, 2, 3, 4 or 5; R a is halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkyl, C 1 -C 6 -haloalkoxy, C 2 -C 6 -alkenyl, C 2 -C 6 -alkenyloxy or C(O)R 5 ; R 1 is halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl which is optionally mono- or polysubstituted by alkyl and/or halogen, C 5 -C 8 -cycloalkenyl which is optionally mono- or polysubstituted by alkyl and/or halogen, OR 6 , SR 6 or NR 7 R 8 ; R 2 is halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl which is optionally mono- or polysubstituted by alkyl and/or halogen, C 5 -C 8 -cycloalkenyl which is optionally mono- or polysubstituted by alkyl and/or halogen, OR 6 , SR 6 or NR 7 R 8 ; R 3 is hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl or C 3 -C 6 -cycloalkyl which is optionally mono- or polysubstituted by alkyl and/or halogen; and the agriculturally acceptable salts of compounds I, plant protection agents, containing at least one compound of general formula I and/or one agriculturally-acceptable salt of I and at least one liquid or solid carrier substance, as well as a method for controlling phytopathogenic fungi.

  本发明涉及通式I的二环化合物，其中X，Y分别独立地为N或C—R4; n为1、2、3、4或5；R为卤素、氰基、C1-C6烷基、C1-C6烷氧基、C1-C6卤代烷基、C1-C6卤代烷氧基、C2-C6烯基、C2-C6烯氧基或C（O）R5；R1为卤素、氰基、C1-C6烷基、C1-C6卤代烷基、C2-C6烯基、C2-C6炔基、C3-C8环烷基，其可以选择性地被烷基和/或卤素单或多取代，C5-C8环烯基，其可以选择性地被烷基和/或卤素单或多取代，OR6，SR6或NR7R8；R2为卤素、氰基、C1-C6烷基、C1-C6卤代烷基、C2-C6烯基、C2-C6炔基、C3-C8环烷基，其可以选择性地被烷基和/或卤素单或多取代，C5-C8环烯基，其可以选择性地被烷基和/或卤素单或多取代，OR6，SR6或NR7R8；R3为氢、C1-C6烷基、C1-C6卤代烷基或C3-C6环烷基，其可以选择性地被烷基和/或卤素单或多取代；以及通式I化合物的农业上可接受的盐、含有至少一种通式I的化合物和/或一种农业上可接受的I的盐和至少一种液体或固体载体物质的植物保护剂，以及一种控制植物病原真菌的方法。
• FUNGICIDAL PYRIDINES
  申请人：Finkelstein Bruce Lawrence

  公开号：US20110092544A1

  公开（公告）日：2011-04-21

  Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein each W and Y is independently CH 2 , O, C(═O), S(═O) n , NR 8 or a direct bond; R 4 is H, halogen, cyano, hydroxy, C 1 -C 2 alkyl, C 1 -C 2 haloalkyl, C 2 alkenyl, C 2 haloalkenyl or C 2 alkynyl; m is an integer selected from 0, 1, 2, 3, 4 and 5; and R 1 , R 2 , R 3 , R 5 , R 8 and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

  公开了式子1的化合物、N-氧化物及其盐，其中每个W和Y独立地为CH2、O、C(═O)、S(═O)n、NR8或直接键；R4为H、卤素、氰基、羟基、C1-C2烷基、C1-C2卤代烷基、C2烯基、C2卤代烯基或C2炔基；m为0、1、2、3、4和5中选的整数；R1、R2、R3、R5、R8和n如本公示中所定义。还公开了含有式子1的化合物的组合物以及用于控制由真菌病原体引起的植物病害的方法，其中包括施用本发明的化合物或组合物的有效量。
• MACROCYCLIC COMPOUNDS FOR MODULATING IL-17
  申请人：ENSEMBLE THERAPEUTICS CORPORATION

  公开号：US20150005319A1

  公开（公告）日：2015-01-01

  The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders.

  本发明涉及公式I的大环化合物及其治疗用途。更具体地，本发明涉及调节IL-17活性或用于治疗医疗情况（例如炎症性疾病和其他IL-17相关疾病）的大环化合物。