N-pentylnaphthalen-2-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-pentylnaphthalen-2-amine
• 化学式: C₁₅H₁₉N
• 分子量: 213.323
• InChiKey: AGICGYPDIXONAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(naphthalen-2-yl)pentanamide 在 劳森试剂 、 4-dimethylaminopyridine borane 、 di-tert-butoxydiazene 、 苯硫酚 作用下， 以 甲苯 为溶剂， 生成 N-pentylnaphthalen-2-amine
  参考文献：
  名称：

  Lewis Base–Boryl Radicals Enabled the Desulfurizative Reduction and Annulation of Thioamides

  摘要：

  A new protocol for radical transformations of thioamides promoted by Lewis base-boryl radicals is reported. The desulfurizative reduction to access organic amines was enabled utilizing 4-dimethylaminopyridine-BH3 as the boryl radical precursor and PhSH as the polarity reversal catalyst. Alternatively, the chain process for unsaturated thioamides was switched to an annulation reaction using N-heterocyclic carbene BH3 as the boryl radical precursor and sterically bulky Ph3CSH as the catalyst, allowing for the construction of N-heterocyclic and carbocyclic skeletons.

  DOI：

  10.1021/acs.orglett.7b03201

文献信息

• [EN] TOLL-LIKE RECEPTOR AGONISTS<br/>[FR] AGONISTES DE RÉCEPTEURS DE TYPE TOLL
  申请人：UNIV KANSAS

  公开号：WO2015023958A1

  公开（公告）日：2015-02-19

  Compounds described herein can be used for therapeutic purposes. The compounds can be TLR agonists, such as TLR7 or TLR8 agonists. The compounds can be included in pharmaceutical compositions and used for therapies were being a TLR agonist is useful. The pharmaceutical compositions can include any ingredients, such as carries, diluents, excipients, fillers or the like that are common in pharmaceutical compositions. The compounds can be those illustrated or described herein as well as derivatives thereof, prodrugs thereof, salts thereof, or stereoisomers thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combinations thereof. As such, the compounds can be used as adjuvants in vaccines, as well as for other therapeutic purposes described herein.

  本文描述的化合物可用于治疗目的。这些化合物可以是TLR激动剂，例如TLR7或TLR8激动剂。这些化合物可以包含在药物组合物中，并用于需要作为TLR激动剂有用的治疗中。药物组合物可以包括任何成分，如载体、稀释剂、赋形剂、填料或类似的在药物组合物中常见的成分。这些化合物可以是本文所示或描述的化合物，以及其衍生物、前药、盐、立体异构体，或在任何手性中心具有任何手性，或互变异构体、多晶形、溶剂化合物，或其组合。因此，这些化合物可以用作疫苗的佐剂，以及用于本文描述的其他治疗目的。
• A novel and efficient approach to mono-N-alkyl anilines via addition of grignard reagents to aryl azides
  作者：H.M. Sampath Kumar、B.V. Subba Reddy、S. Anjaneyulu、J.S. Yadav

  DOI：10.1016/s0040-4039(99)01771-2

  日期：1999.11

  Mono-N-alkyl anilines were obtained in high yields within a short reaction time when various aromatic azides were reacted with alkyl magnesium halides at room temperature.

  单Ñ当各种芳族叠氮化物用在室温下的烷基卤化镁反应，短的反应时间内以高产率得到烷基苯胺。
• Porphyrinhaltige Silicone mit erhöhter Temperaturbeständigkeit
  申请人：Wacker-Chemie GmbH

  公开号：EP0748838A1

  公开（公告）日：1996-12-18

  Die Siliconmassen, insbesondere Siliconöle und vernetzbare Siliconmassen enthalten Porphyrine als Hitzestabilisator.

  硅化合物，特别是硅油和可交联硅化合物，含有卟啉作为热稳定剂。
• A lubricating oil composition
  申请人：Infineum International Limited

  公开号：EP2457984A1

  公开（公告）日：2012-05-30

  A low sulphated ash lubricating oil composition comprises an ashless aromatic amine antioxidant and an overbased magnesium detergent which exhibits improved thermal oxidation stability.

  一种低硫酸盐灰分润滑油组合物由一种无灰芳香胺抗氧化剂和一种过基镁洗涤剂组成，具有更好的热氧化稳定性。
• Process for the regiospecific sulfonation of 2-amino-naphtalenes substituted in the 5- or 7-position by a fibre reactive vs-group, the novel 5-sulfo-substituted fiber-reactive 2-amino-naphthalene, and fibre-reactive azo dyes thereof
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0344343B1

  公开（公告）日：1993-04-21