4,4-dimethyl-3-phenyltetrahydro-2H-pyran | 1408286-13-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 4,4-dimethyl-3-phenyltetrahydro-2H-pyran
• 英文别名: 4,4-Dimethyl-3-phenyloxane
• CAS: 1408286-13-4
• 化学式: C₁₃H₁₈O
• 分子量: 190.285
• InChiKey: LSQUBKFCEVKKAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3,3-dimethyl-4-phenylpent-4-enoic acid 在 lithium aluminium tetrahydride 、 2-苯基丙二腈 、 sodium hydroxide 、 10-甲基-9-均三甲苯基吖啶高氯酸盐 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 72.17h， 生成 4,4-dimethyl-3-phenyltetrahydro-2H-pyran
  参考文献：
  名称：

  Direct Catalytic Anti-Markovnikov Hydroetherification of Alkenols

  摘要：

  A direct intramolecular anti-Markovnikov hydroetherification reaction of alkenols is described. By employing Catalytic quantities of commercially available 9-mesityl-10-methylacridinium perchlorate and 2-phenyl-malononitrile as a redox-cycling source of a H-atom, we report the anti-Markovnikov hydroetherification of alkenes with complete regioselectivity, In addition, we present results demonstrating that this novel catalytic system can be applied to the anti-Markovnikov hydrolactonization of alkenoic acids.

  DOI：

  10.1021/ja309635w

文献信息

• DIRECT ANTI-MARKOVNIKOV ADDITION OF ACIDS TO ALKENES
  申请人：The University of North Carolina at Chapel Hill

  公开号：US20150133680A1

  公开（公告）日：2015-05-14

  A method of making an anti-Markovnikov addition product is carried out by reacting an acid with an alkene or alkyne in a dual catalyst reaction system to the exclusion of oxygen to produce said anti-Markovnikov addition product; the dual catalyst reaction system comprising a single electron oxidation catalyst in combination with a hydrogen atom donor catalyst. Compositions useful for carrying out such methods are also described.
• US9365530B2
  申请人：——

  公开号：US9365530B2

  公开（公告）日：2016-06-14