bis(2-ethoxyethyl)benzylphosphine | 166770-88-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(2-ethoxyethyl)benzylphosphine
• 英文别名: benzylbis(2-ethoxyethyl)phosphane；benzylbis(2-ethoxyethyl)phosphine；Benzyl-bis(2-ethoxyethyl)phosphane
• CAS: 166770-88-3
• 化学式: C₁₅H₂₅O₂P
• 分子量: 268.336
• InChiKey: LTHFDXFAHBPADC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  bis(2-ethoxyethyl)benzylphosphine 在 水 、 sodium hydroxide 作用下， 以 乙醇 、 乙腈 为溶剂， 生成 ethane-1,2-diylbis(bis(2-ethoxyethyl)phosphine oxide)
  参考文献：
  名称：

  [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF TETROFOSMIN OR ACID ADDITION SALT THEREOF
  [FR] PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE TÉTROFOSMINE OU D'UN SEL DE QUALITÉ PHARMACEUTIQUE DE CELLE-CI

  摘要：

  本发明涉及一种改进的制备四氟硫醚或其酸盐的方法。本发明还涉及制备四氟硫醚二磺基水杨酸盐的方法。此外，本发明还提供了四氟硫醚二磺基水杨酸盐的J形态的多晶形式。

  公开号：

  WO2018162964A1
• 作为产物：
  描述：

  diethyl benzylphosphonate 在 lithium aluminium tetrahydride 作用下， 生成 bis(2-ethoxyethyl)benzylphosphine
  参考文献：
  名称：

  Synthesis of the myoview™ ligand, [bisphosphinoethane-1,2-14C]tetrofosmin

  摘要：

  通过将 1,2-二溴[U-14C]乙烷与双（2-乙氧基乙基）苄基膦（1）反应，可以很容易地引入[双膦乙烷-1,2-14C]四磷酸盐配体中的碳-14 放射性标记。该配体转化为 Myoview™ 配体的总产率为 45%。这种放射合成技术对获得监管机构的上市许可非常重要，并使 Myoview™ 成为当今主要的心脏成像剂之一。版权所有 © 2007 John Wiley & Sons, Ltd. 保留所有权利。

  DOI：

  10.1002/jlcr.1199

文献信息

• Complexes of electropositive metals with a hemilabile ether phosphine. Crystal structures of [TiCl4L], [FeL2(O3SCF3)2] and [Mo(CO)3L2][L = PhCH2P(CH2CH2OEt)2]
  作者：Steven J. Chadwell、Simon J. Coles、Peter G. Edwards、Michael B. Hursthouse

  DOI：10.1039/dt9960001105

  日期：——

  New complexes containing some early transition metals with benzylbis(2-ethoxyethyl)phosphine (L) have been prepared. Reaction of this potentially hemilabile terdentate ligand with TiCl4 afforded [TiCl4L]1. The crystal structure shows the metal to have a distorted-octahedral geometry, where the ligand acts as a P,O-bonding chelate. Reaction of 1 with AgBF4 and AgO3SCF3 afforded yellow oils which could not be fully characterised, but are tentatively assigned as [TiCl3L][BF4] and [TiCl3L][O3SCF3] respectively. The reaction of [Cr(MeCN)3(CO)3] with L resulted in the formation of [Cr(CO)4L2]2 in poor yield. This complex can be prepared in high yield by the reaction of [Cr(MeCN)2(CO)4] with L. The reaction of [M(CO)3(C6H3Me3-2,4,6)](M = Mo or W) with L gave the complex fac-[Mo(CO)3L2]3 and [M(CO)4L2](M = Mo 4 or W 5) depending upon reaction conditions. The crystal structure of 3 shows the metal to have a distorted-octahedral geometry, where one L bonds as a P,O chelate and the other as a P-donor. 31P-1H} NMR spectroscopy indicates this complex to be fluxional in solution, where the two ligands readily interchange at high temperatures. The iron(II) complex [FeL2(O3SCF3)2]6 was prepared by the reaction of L and FeCl2·4H2O with AgO3SCF3. Its crystal structure shows the metal to have a distorted-octahedral geometry with trans ligands (through phosphorus and oxygen) and trans-co-ordinating triflates.

  已制备出含有一些早期过渡金属与苄基双(2-乙氧基乙基)膦(L)的新络合物。这种潜在的半不稳定三齿配体与 TiCl4 反应得到 [TiCl4L]1。晶体结构显示该金属具有扭曲的八面体几何形状，其中配体充当 P,O 键合螯合物。 1 与 AgBF4 和 AgO3SCF3 反应得到黄色油状物，无法完全表征，但暂时分别指定为 [TiCl3L][BF4] 和 [TiCl3L][O3SCF3]。 [Cr(MeCN)3(CO)3] 与 L 的反应导致形成 [Cr(CO)4L2]2，但产率较低。该配合物可以通过 [Cr(MeCN)2(CO)4] 与 L 的反应以高产率制备。 [M(CO)3(C6H3Me3-2,4,6)](M = Mo 或W) 与 L 得到配合物 fac-[Mo(CO)3L2]3 和 [M(CO)4L2](M = Mo 4 或 W 5)，具体取决于反应条件。 3 的晶体结构显示该金属具有扭曲的八面体几何形状，其中一个 L 作为 P,O 螯合物键合，另一个作为 P-供体。 31P-1H} NMR 光谱表明该配合物在溶液中是流动的，其中两个配体在高温下很容易互换。 L和FeCL2·4H2O与AgO3SCF3反应制备了铁(II)配合物[FeL2(O3SCF3)2]6。其晶体结构显示该金属具有带有反式配体（通过磷和氧）和反式配位三氟甲磺酸酯的扭曲八面体几何形状。
• Synthesis and characterization of group 10 metal complexes with a new trifunctional ether phosphine. The X-ray crystal structures of bis[bis(2-ethoxyethyl)benzylphosphine] dichloronickel(II) and bis[bis(2-ethoxyethyl)benzylphosphine]chlorophenylnickel(II)
  作者：Steven J. Chadwell、Simon J. Coles、Peter G. Edwards、Michael B. Hursthouse、Ahmed Imran

  DOI：10.1016/0277-5387(94)00343-d

  日期：1995.4

  The synthesis and characterizations of the new trifunctional ligand bis(2-ethoxyethyl)benzylphosphine (OPO ; 1) and some new group 10 metal complexes are described. Reactions of this potentially hemilabile ligand with the nickel, palladium and platinum chlorides have been studied, resulting in isolation of the series, MCl2(OPO)2, where M = Ni (2), Pd (3) or Pt (4). The X-ray crystal structure of 2

  摘要描述了新型三官能配体双（2-乙氧基乙基）苄基膦（OPO; 1）以及一些新型的第10族金属配合物的合成和表征。已经研究了这种可能具有半挥发性的配体与氯化镍，钯和氯化铂的反应，从而分离出MCl2（OPO）2系列，其中M = Ni（2），Pd（3）或Pt（4）。2的X射线晶体结构显示金属具有正方形平面反式排列，其中配位体通过磷中心通过η1-键键合。化合物3和4也是反式的。使用NaBPh4尝试与镍形成氧/磷螯合物，生成了新的反式NiClPh（OPO）2络合物（5），通过X射线晶体学显示其为方形平面，带有反氯和苯基基团。还准备了2的二溴类似物（6），
• Process for the preparation of tetrofosmin or acid salt thereof
  申请人：Jubilant Generics Limited

  公开号：US10836781B2

  公开（公告）日：2020-11-17

  The present invention relates to an improved process for the preparation of tetrofosmin or acid addition salt thereof. The present invention also relates to the process for the preparation of tetrofosmin disulfosalicylate salt. Further the present invention also provides the polymorphic form J of disulfosalicylate salt of tetrofosmin.

  本发明涉及一种制备四氟磷胺或其酸加成盐的改进工艺。本发明还涉及四螨嗪二磺酸水杨酸盐的制备工艺。此外，本发明还提供了四氟磷胺二磺酸水杨酸盐的多晶型J。
• Chelating ether–phosphine complexes of the cobalt group metals. Crystal structures of bis[benzylbis(2-ethoxyethyl)-phosphine]-bis(trifluoromethanesulfonato)cobalt(<scp>II</scp>) and -trichlororhodium(<scp>III</scp>)
  作者：Steven J. Chadwell、Simon J. Coles、Peter G. Edwards、Michael B. Hursthouse

  DOI：10.1039/dt9950003551

  日期：——

  New Group 9 metal complexes have been prepared using the trifunctional ligand benzylbis(2-ethoxyethyl)phosphine (L). Reactions of this potentially hemilabile ligand with CoCl2, and CoCl2 . 6H(2)O with AgCF3SO3, have been studied, resulting in the isolation of [CoCl(2)L(2)] 1 and [CoL(2)(O3SCF3)(2)] 2 respectively. In the former complex L acts as a monodentate P-bonding ligand with the metal adopting a tetrahedral geometry, but in the latter it acts as an O,P chelate. The crystal structure for 2 has been determined and shows the metal to have a distorted-octahedral geometry with trans ligands (P and O) and trans triflates. The P-31-H-1} NMR spectrum of 2 suggests the formation of a dimeric species in solution, Reactions of L with RhCl3 . 3H(2)O, [RhCl(CO)(2)}(2)] and [RhCl(cod)}(2)] (cod = cycloocta-1,5-diene) resulted in the isolation of [RhCl(3)L(2)] 3, [RhCl(CO)L(2)] 4 and [RhCl(cod)L] 5 respectively, where L acts as a monodentate P-bonding ligand in 4 and 5. Complex;4 is shown to be trans by NMR studies. In 3 the ligand bonds as a monodentate phosphorus donor in one case and as a bidentate O,P chelate in the other. The crystal structure of 3 has been determined and shows the metal to have a slightly distorted-octahedral mer arrangement with cis phosphorus donors. The fluxional nature of this complex has been monitored by variable-temperature P-31-(H-1) and H-1 NMR spectroscopy which shows that these ligands readily interchange at high temperatures. The iridium analogue of 5 has been prepared from [IrCl(cod)}(2)] resulting in the isolation of [IrCl(cod)L] 6. The reaction of 3 with cyclohexene gave an unstable alkene complex 7 which could not be isolated. but was identified by variable-temperature P-31-H-1} NMR studies.