(4-hydroxy-[1,1′-biphenyl]-3,5-diyl)dimethanol | 3173-26-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-hydroxy-[1,1′-biphenyl]-3,5-diyl)dimethanol
• 英文别名: (4-hydroxy-[1,1'-biphenyl]-3,5-diyl)dimethanol；(4-hydroxy-[1,1'-biphenyl]3,5-diyl)dimethanol；o,o'-bis(hydroxymethyl)-p-phenylphenol；2,6-dihydroxymethyl-4-phenylphenol；4-Hydroxy-3,5-bis-hydroxymethyl-biphenyl；2,6-Bis-hydroxymethyl-4-phenyl-phenol；2,6-Bis(hydroxymethyl)-4-phenylphenol
• CAS: 3173-26-0
• 化学式: C₁₄H₁₄O₃
• 分子量: 230.263
• InChiKey: KESDEZVYQGSTHN-UHFFFAOYSA-N

物化性质

• 熔点：
  110-111.5 °C
• 沸点：
  428.9±24.0 °C(Predicted)
• 密度：
  1.273±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-hydroxy-[1,1′-biphenyl]-3,5-diyl)dimethanol 以 水 为溶剂， 生成 2-<3-(5-phenylsalicyl)-5-phenylsalicyl>-4-phenylphenol
  参考文献：
  名称：

  Lamartine, Roger; Perrin, Robert; Vicens, Jacques, Molecular Crystals and Liquid Crystals (1969-1991), 1986, vol. 134, p. 219 - 236

  摘要：

  DOI：
• 作为产物：
  描述：

  对羟基联苯 在 sodium hydroxide 、 聚合甲醛 作用下， 生成 (4-hydroxy-[1,1′-biphenyl]-3,5-diyl)dimethanol
  参考文献：
  名称：

  Zinke; Hanus; Ziegler, Journal fur praktische Chemie (Leipzig 1954), 1939, vol. <2> 152, p. 126,135

  摘要：

  DOI：

文献信息

• Novolac resin-containing resist underlayer film-forming composition using bisphenol aldehyde
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US10017664B2

  公开（公告）日：2018-07-10

  Resist underlayer film-forming composition for forming resist underlayer film with high dry etching resistance, wiggling resistance and exerts good flattening property and embedding property for uneven parts, including resin obtained by reacting organic compound A including aromatic ring and aldehyde B having at least two aromatic hydrocarbon ring groups having phenolic hydroxy group and having structure wherein the aromatic hydrocarbon ring groups are bonded through tertiary carbon atom. The aldehyde B may be compound of Formula (1): The obtained resin may have a unit structure of Formula (2): Ar1 and Ar2 each are C6-40 aryl group. The organic compound A including aromatic ring may be aromatic amine or phenolic hydroxy group-containing compound. The composition may contain further solvent, acid and/or acid generator, or crosslinking agent. Forming resist pattern used for semiconductor production, including forming resist underlayer film by applying the resist underlayer film-forming composition onto semiconductor substrate and baking it.

  用于形成具有高干法蚀刻抗性、抗扭曲性并具有良好的平整性和嵌入性能的抗蚀底层膜形成组合物，包括通过使含有芳香环的有机化合物A和至少具有两个含酚羟基的芳香烃环团的醛B反应而获得的树脂，并具有芳香烃环团通过三级碳原子键合的结构。醛B可以是化合物的化学式（1）： 所得的树脂可能具有化学式（2）的单元结构： Ar1和Ar2各自是C6-40芳基团。含有芳香环的有机化合物A可能是芳香胺或含酚羟基的化合物。该组合物可能进一步含有溶剂、酸和/或酸发生剂，或交联剂。用于半导体生产的形成抗蚀图案，包括通过将抗蚀底层膜形成组合物涂覆在半导体衬底上并对其进行烘烤来形成抗蚀底层膜。
• Facile synthesis of calix[4]arenes in ABAC type upper rim substitution
  作者：Kwanghyun No、Jong Eun Kim、Kyoung Mee Kwon

  DOI：10.1016/0040-4039(95)01820-8

  日期：1995.11

  Calix[4]arenes with three different substituents in ABAC pattern at the upper rim of calix are synthesized by '3 + 1' fragmentation condensation reaction between trimer of p-substituted phenol (ABA) and 2.6-bishydroxymethylated p-substituted phenol (C).

  通过在对位取代苯酚（ABA）的三聚体和2.6-双羟甲基化对位取代苯酚（C）的'3 +1'片段缩合反应合成杯中杯上部边缘ABAC模式中具有三个不同取代基的杯杯[4]芳烃。
• Syntheses of Biphenyl Analogues of AP7, a New Class of Competitive<i>N</i>-Methyl-<scp>D</scp>-aspartate (NMDA) Receptor Antagonists
  作者：Werner Müller、Peter Kipfer、David A. Lowe、Stephan Urwyler

  DOI：10.1002/hlca.19950780810

  日期：1995.12.13

  Syntheses of a series of enantiomerically pure, substituted analogues 7b–t of SDZ EAB 515 (7a) were described (Schemes 1 and 2). Affinites for the NMDA receptor were measured ([3H]CGP-39653 binding assay) and competitive NMDA antagonistic potencies determined in a functional test (rat neocortical slice preparation). Structure-activity relationships show that attachment of an OH group at position 4

  描述了SDZ EAB 515（7a）的一系列对映体纯的，取代的类似物7b–t的合成（方案1和2）。测量了NMDA受体的界限（[ 3 H] CGP-39653结合测定），并在功能测试（大鼠新皮层切片制剂）中确定了竞争性NMDA拮抗力。结构-活性关系表明，在联苯部分的链插入苯环的4位上连接一个OH基团和/或两个邻环取代基扩大了两个苯环平面之间的夹角，从而增加了体外活性。低纳摩尔范围。
• Synthesis, Structures, and Conformational Characteristics of Triptycene-Derived Calix[5]arenes
  作者：Xiao-Hong Tian、Chuan-Feng Chen

  DOI：10.1021/ol902758g

  日期：2010.2.5

  A series of novel calix[5]arenes 5 containing one 1,8-dimethoxytriptycene moiety were synthesized through an efficient fragment coupling strategy. The subsequent demethylation of 5 with BBr3 in dry dichloromethane gave the calix[5]arenes 6. Debutylation of both 5a∼b and 6a∼b with AlCl3 resulted in the same products 7a∼7b. The structural studies revealed that all of the macrocyclic compounds have well-defined

  通过一种有效的片段偶联策略，合成了一系列含有一个1,8-二甲氧基三萜烯部分的新杯[5]芳烃5。随后在干燥的二氯甲烷中用BBr 3将5脱甲基，得到杯[5]芳烃6。两者的Debutylation图5a〜b和图6a〜b与的AlCl 3，导致在相同的产品图7a〜图7b。结构研究表明，所有大环化合物均具有明确定义的结构，在溶液和固态下均具有固定的圆锥构象。此外，还发现三萜烯衍生的杯[5]芳烃可以包裹固态的中性小分子。
• Synthesis and Reactions of Triptycene-Derived Bromocalix[5]arenes: Conformational Transformation from Cone to 1,2-Alternate
  作者：Yu-Xiang Xia、Ying Han、Chuan-Feng Chen

  DOI：10.1002/ejoc.201301668

  日期：2014.3

  reactions were then carried out. As a result, a series of triptycene-derived calix[5]arene derivatives in fixed cone and 1,2-alternate conformations were obtained. Moreover, conformation transformations of triptycene-derived calix[5]arenes from cone to 1,2-alternate forms could also be achieved.

  Triptycene 衍生的 p-dibromocalix[5] 芳烃是通过片段偶联方法合成的，而对含有三个对叔丁基苯酚基团和一个 1,8-dimethyltriptycene 部分的三苯乙烯衍生的杯 [5] 芳烃的处理溴在二氯甲烷中在室温下直接产生三苯乙烯衍生的对五溴环[5]芳烃。然后进行甲基醚化和 Suzuki 偶联反应。结果，获得了一系列固定锥和1,2-交替构象的三苯乙烯衍生的杯[5]芳烃衍生物。此外，还可以实现三苯乙烯衍生的杯[5]芳烃从锥形到1,2-交替形式的构象转换。