perfluorocycloheptane | 355-59-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: perfluorocycloheptane
• 英文别名: tetradecafluoro-cycloheptane；Tetradecafluor-cycloheptan；Perfluorcycloheptan；Perfluoro-heptan；Cycloheptane, tetradecafluoro-；1,1,2,2,3,3,4,4,5,5,6,6,7,7-tetradecafluorocycloheptane
• CAS: 355-59-9
• 化学式: C₇F₁₄
• 分子量: 350.055
• InChiKey: FNVLGCVAWPSVSK-UHFFFAOYSA-N

物化性质

• 熔点：
  40 °C
• 沸点：
  80.75°C (rough estimate)
• 密度：
  1.74±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 fluorine 、 mercury(II) chloride 作用下， 生成 perfluorocycloheptane
  参考文献：
  名称：

  Fluorocarbons. The Reaction of Fluorine with Carbon

  摘要：

  DOI：

  10.1021/ja01265a111

文献信息

• [EN] GEL FORMULATIONS FOR ENHANCING THE EFFECT OF RADIOTHERAPY<br/>[FR] FORMULATIONS DE GEL POUR AMÉLIORER L'EFFET DE RADIOTHÉRAPIE
  申请人：UNIV DENMARK TECH DTU

  公开号：WO2016079331A1

  公开（公告）日：2016-05-26

  The present invention relates to a composition comprising: a. non-water soluble carbohydrates b. a contrast agent for imaging, wherein at least 60% of the contrast agent remains within 10 cm from the injection site after 24h, for use in local co-administration into a human or animal body, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration.

  本发明涉及一种包含以下成分的组成物：a. 非水溶性碳水化合物 b. 成像的对比剂，其中至少60%的对比剂在24小时后保持在注射部位10厘米范围内，用于在人体或动物体内局部共同给药，并且该组成物在给药前为液态，在给药后在粘度上增加超过1,000厘泊（cP）。
• Polyfluoro-compounds based on the cycloheptane ring system. Part 1. Compounds derived from tridecafluorocycloheptane
  作者：John A. Oliver、Robert Stephens、John Colin Tatlow

  DOI：10.1016/s0022-1139(00)81486-4

  日期：1983.1

  cycloheptane: the former was demethylated by sulphuric acid to dodecafluorocycloheptanone. The dichloro-adduct of the perfluoro-olefin was reduced by lithium aluminium hydride to a complex mixture, from which 1H/2H- and 1H,2H/-dodecafluorocycloheptane were isolated.

  用氟化钴对环庚烷进行部分氟化，得到了多氟化物的混合物，其中十三氟环庚烷的含量很高。用碱金属水溶液得到十二氟环庚烯，用氢化铝锂得到十二氢氟环庚基-1-烯。这些环烯烃中的每一个都被氧化成十氟庚二酸。甲醇/ KOH与十二氟环庚烯反应，主要生成1-甲氧基-十一氟环庚-1-烯以及约15％的3-甲氧基-异构体，以及一些1,2-二甲氧基十氟环庚-1-烯。1-甲氧基-1-烯和氟化钴产生1-甲氧基-和1-氟甲氧基-三氟乙烷-氟环庚烷：前者被硫酸脱甲基成十二氟环庚酮。全氟烯烃的二氯加合物被氢化铝锂还原成复杂的混合物，
• [EN] GEL FORMULATIONS FOR IMPROVING IMMUNOTHERAPY<br/>[FR] FORMULATIONS DE GEL PERMETTANT D'AMÉLIORER L'IMMUNOTHÉRAPIE
  申请人：UNIV DENMARK TECH DTU

  公开号：WO2016079332A1

  公开（公告）日：2016-05-26

  The present invention relates to a composition for use as controlled release of at least one active pharmaceutical ingredient that modulates an immunogenic response in a human or animal body, said composition comprising non-water soluble carbohydrates and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 1,000 centipoise (cP) after administration.

  本发明涉及一种用作控制释放至少一种活性药物成分的组合物，该活性药物成分调节人体或动物体内的免疫应答，所述组合物包括非水溶性碳水化合物，并且在进入人体或动物体内之前是液体，在给药后粘度增加超过1,000厘泊（cP）。
• [EN] PALPABLE MARKER COMPOSITION<br/>[FR] COMPOSITION DE MARQUAGE PALPABLE
  申请人：UNIV DENMARK TECH DTU

  公开号：WO2017198858A1

  公开（公告）日：2017-11-23

  The present invention relates to a palpable marker composition comprising non-water soluble carbohydrates, wherein at least 50% of the non-water soluble carbohydrates are carbohydrates selected from derivatives of lactose, maltose, trehalose, raffinose, glucosamine, galactosamine, lactosamine, or derivatives of disaccharides with at least two pyranose saccharide units, trisaccharides, tetrasaccharides, or mixtures thereof, and wherein the composition is a liquid before administration into the human or animal body and increases in viscosity by more than 50,000 centipoise (cP) after administration, for use for identifying and/or locating a non palpable tumor. In one embodiment the composition the composition is a liquid before administration into the human or animal body that increases in viscosity by more than 500,000 centipoise (cP) after administration into the human or animal body. In another embodiment the composition is a liquid before administration and has the ability to transform into a crystalline or amorphous solid after administration.

  本发明涉及一种可触及标记剂组合物，包括非水溶性碳水化合物，其中至少50％的非水溶性碳水化合物是从乳糖衍生物、麦芽糖、海藻糖、蔗糖、氨基葡萄糖、氨基半乳糖、氨基乳糖或至少有两个吡喃糖单元的二糖衍生物、三糖、四糖或其混合物中选择的碳水化合物，并且在进入人体或动物体内之前是液体，并在进入后的粘度增加了超过50,000厘泊（cP），用于识别和/或定位不可触及的肿瘤。在一个实施例中，该组合物在进入人体或动物体内之前是液体，在进入人体或动物体后的粘度增加了超过500,000厘泊（cP）。在另一个实施例中，该组合物在进入前是液体，并且具有在进入后转变为结晶或无定形固体的能力。
• METHOD FOR PRODUCING TETRAFLUORO COMPOUND
  申请人：Miyashita Yasuhiro

  公开号：US20110178323A1

  公开（公告）日：2011-07-21

  Provided is a method for producing a tetrafluoro nitrogen-containing heterocyclic compound such as tetrafluoropyrrolidine in good yield and at low cost. The method comprises the steps of: (A) reacting a compound represented by the formula (I) with fluorine gas to produce a tetrafluoro compound represented by the formula (II), (B) converting the tetrafluoro derivative represented by the formula (II) to a compound represented by the formula (III), and (C) reacting the compound represented by the formula (III) with an amine compound represented by the formula NH 2 R 9 to produce a tetrafluoro nitrogen-containing heterocyclic compound represented by the formula (IV) or salt thereof.

  提供了一种生产四氟氮含杂环化合物（如四氟吡咯烷）的方法，产率高且成本低。该方法包括以下步骤：（A）将式（I）表示的化合物与氟气反应，生成式（II）表示的四氟化合物，（B）将式（II）表示的四氟衍生物转化为式（III）表示的化合物，以及（C）将式（III）表示的化合物与式NH2R9表示的胺化合物反应，生成式（IV）表示的四氟氮含杂环化合物或其盐。