1,5-Disuccinimidopentan | 57531-07-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,5-Disuccinimidopentan
• 英文别名: 1-[5-(2,5-Dioxopyrrolidin-1-yl)pentyl]pyrrolidine-2,5-dione
• CAS: 57531-07-4
• 化学式: C₁₃H₁₈N₂O₄
• 分子量: 266.297
• InChiKey: VVMYTMLMKSVPIG-UHFFFAOYSA-N

物化性质

• 熔点：
  59-62 °C
• 沸点：
  526.4±33.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,5-Dioxo-1,6-diaza-cyclo-undecan 以61%的产率得到
  参考文献：
  名称：

  GRINBERG H.; LAMDAN S.; GAOZZA C., J. HETEROCYCL. CHEM. , 1975, 12, NO 4, 763-766

  摘要：

  DOI：

文献信息

• [EN] MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS<br/>[FR] COMPLEXES À BASE DE MANGANÈSE ET LEURS UTILISATIONS SERVANT À UNE CATALYSE HOMOGÈNE
  申请人：YEDA RES & DEV

  公开号：WO2017137984A1

  公开（公告）日：2017-08-17

  The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di- lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

  本发明涉及新型锰配合物及其用途，包括但不限于在以下领域进行均相催化：（1）通过醇和胺的脱氢偶联制备亚胺；（2）使用腈作为迈克尔供体进行迈克尔加成反应中的C-C偶联；（3）将醇脱氢偶联以得到酯和氢气；（4）将酯加氢以形成醇（包括环酯（内酯）或环二酯（二内酯）或聚酯的加氢）；（5）将酰胺（包括环二肽、内酰胺、二酰胺、多肽和聚酰胺）加氢以得到醇和胺（或二胺）；（6）将有机碳酸酯（包括聚碳酸酯）加氢以得到醇或将氨基甲酸酯（包括聚氨基甲酸酯）或脲衍生物加氢以得到醇和胺；（7）将二级醇脱氢以得到酮；（8）酯的酰胺化（即从酯和胺合成酰胺）；（9）使用酯对醇进行酰化；（10）将醇与水和碱偶联以形成羧酸；以及（11）通过氨基醇与水和碱的偶联制备氨基酸或其盐。（12）通过醇和胺的脱氢偶联制备酰胺（包括甲酰胺、环二肽、二酰胺、内酰胺、多肽和聚酰胺）；（13）从二醇制备酰亚胺。
• MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS
  申请人：Yeda Research and Development Co. Ltd

  公开号：EP3919466A1

  公开（公告）日：2021-12-08

  The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

  本发明涉及新型锰络合物及其在以下方面的均相催化等用途：(1)通过醇和胺的脱氢偶联制备亚胺；(2)在迈克尔加成反应中使用腈作为迈克尔供体的C-C偶联；(3) 醇的脱氢偶联生成酯和氢气 (4) 酯的氢化生成醇（包括环酯（内酯）或环二酯（二内酯）或聚酯的氢化）；(5) 将酰胺（包括环状二肽、内酰胺、二酰胺、多肽和多酰胺）氢化成醇和胺（或 二胺）；(6) 将有机碳酸盐（包括聚碳酸酯）氢化成醇，或将氨基甲酸酯（包括聚氨基甲 酸酯）或脲衍生物氢化成醇和胺；(7) 将仲醇脱氢成酮；(8) 酯的酰胺化（即酰胺化）。e.,(10) 醇与水和碱偶联生成羧酸；以及 (11) 通过氨基醇与水和碱偶联制备氨基酸或其盐。(12) 通过醇和胺的脱氢偶联制备酰胺（包括甲酰胺、环二肽、二酰胺、内酰胺、多肽和多酰胺）； (13) 利用二元醇制备亚胺。
• Shiga toxin a subunit effector polypeptides, Shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
  申请人：Molecular Templates, Inc.

  公开号：US11389542B1

  公开（公告）日：2022-07-19

  The present invention provides Shiga toxin A Subunit derived polypeptides, scaffolds, and cell-targeting molecules comprising amino acid substitutions which equip the molecules with site-specific positions (and often unique amino acid residues in the molecule) for linking other molecules while retaining Shiga toxin function(s), such as, e.g., efficient intracellular routing and/or potent cytotoxicity. The present invention also provides cell-targeting molecules, and/or components thereof, which comprise site-specific positions for linking other molecules, such as, e.g., agents that alters a property of the cell-targeting molecule or a cargo for delivery. Certain molecules comprising a polypeptide of the present invention exhibit reduced immunogenicity and/or are well-tolerated by mammals. The cell-targeting molecules of the present invention, and compositions thereof, have uses, e.g., for the selective delivery of cargos to target-expressing cells and as diagnostic and/or therapeutic molecules for the treatment of a variety of diseases, disorders, and conditions, which include genetic disorders, genetic predispositions, infections, cancers, tumors, growth abnormalities, and/or immune disorders.

  本发明提供了志贺毒素A亚基衍生的多肽、支架和细胞靶向分子，它们包含氨基酸取代，使分子具有连接其他分子的位点特异性位置（通常是分子中独特的氨基酸残基），同时保留志贺毒素的功能，如高效细胞内路由和/或强细胞毒性。本发明还提供了细胞靶向分子和/或其组分，它们包括用于连接其他分子的特异位点，例如，改变细胞靶向分子或运载货物特性的制剂。某些包含本发明多肽的分子显示出较低的免疫原性和/或对哺乳动物具有良好的耐受性。本发明的细胞靶向分子及其组合物具有多种用途，例如，可选择性地将载体递送至靶表达细胞，并可作为诊断和/或治疗分子用于治疗多种疾病、失调和病症，其中包括遗传性失调、遗传倾向、感染、癌症、肿瘤、生长异常和/或免疫失调。
• SHIGA TOXIN A SUBUNIT EFFECTOR POLYPEPTIDES, SHIGA TOXIN EFFECTOR SCAFFOLDS, AND CELL-TARGETING MOLECULES FOR SITE-SPECIFIC CONJUGATION
  申请人：Molecular Templates, Inc.

  公开号：EP3551645A1

  公开（公告）日：2019-10-16
• OPHTHALMOLOGISCHES OPERATIONSSET SOWIE EINE KONTAKTLINSE
  申请人：Geuder AG

  公开号：EP3743024A1

  公开（公告）日：2020-12-02