bis(4-hydroxyphenyl)methanone O-isopentyl oxime

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(4-hydroxyphenyl)methanone O-isopentyl oxime
• 英文别名: 4-[C-(4-hydroxyphenyl)-N-(3-methylbutoxy)carbonimidoyl]phenol
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.37
• InChiKey: RXYDHMNSOMERHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  62
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(3-methylbutoxy)-1H-isoindole-1,3(2H)-dione 在 一水合肼 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 bis(4-hydroxyphenyl)methanone O-isopentyl oxime
  参考文献：
  名称：

  Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism

  摘要：

  In this study, a series of bis(4-hydroxy) benzophenone oxime ether derivatives such as 12c, 12e and 12h were identified as novel estrogen receptor (ER) agonists that have additional and complementary anti-proliferative activities via ER-independent mechanism in cancer cells. These compounds are expected to overcome the therapeutic limitation of existing ER agonists such as estradiol and tamoxifen, which have been known to induce the proliferation of cancer cells. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2016.01.089

文献信息

• Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism
  作者：Taelim Kim、Hye-In Kim、Ji-Young An、Jun Lee、Na-Rae Lee、Jinyuk Heo、Ji-Eun Kim、Jihyun Yu、Yong Sup Lee、Kyung-Soo Inn、Nam-Jung Kim

  DOI：10.1016/j.bmcl.2016.01.089

  日期：2016.4

  In this study, a series of bis(4-hydroxy) benzophenone oxime ether derivatives such as 12c, 12e and 12h were identified as novel estrogen receptor (ER) agonists that have additional and complementary anti-proliferative activities via ER-independent mechanism in cancer cells. These compounds are expected to overcome the therapeutic limitation of existing ER agonists such as estradiol and tamoxifen, which have been known to induce the proliferation of cancer cells. (C) 2016 Elsevier Ltd. All rights reserved.