2,2-dimethyl-N-{8-oxatricyclo[7.4.0.0^2,7]trideca-1(13),2(7),3,5,9,11-hexaen-5-yl}propanamide | 373367-57-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2,2-dimethyl-N-{8-oxatricyclo[7.4.0.0^2,7]trideca-1(13),2(7),3,5,9,11-hexaen-5-yl}propanamide
• 英文别名: N-(dibenzofuran-3-yl)-2,2-dimethylpropionamide；N-dibenzofuran-3-yl-2,2-dimethylpropanamide
• CAS: 373367-57-8
• 化学式: C₁₇H₁₇NO₂
• 分子量: 267.327
• InChiKey: WMGBYCABAUPEMX-UHFFFAOYSA-N

物化性质

• 沸点：
  472.3±18.0 °C(Predicted)
• 密度：
  1.198±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-二甲基甲酰胺 、 2,2-dimethyl-N-{8-oxatricyclo[7.4.0.0^2,7]trideca-1(13),2(7),3,5,9,11-hexaen-5-yl}propanamide 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 3.0h， 以67%的产率得到N-(4-formyldibenzofuran-3-yl)-2,2-dimethylpropionamide
  参考文献：
  名称：

  摘要：

  2-, 3- and 4-Pivaloylamino derivatives of dibenzofuran [compounds (5), (4) and (6), respectively] and analogous 3-, 2- and 1-substituted derivatives of 9-methylcarbazole [compounds (8), (7) and (9), respectively] were subjected to lithiation at 0 degreesC and subsequent reaction with dimethylformamide. Aldehyde formation took place at positions alpha to delta to the heteroatom as follows: alpha for (4) and (7); delta for (5); delta and beta (3 : 1) for (8); and alpha' for (6). No formylation occurred with (9).

  DOI：

  10.1071/ch01017
• 作为产物：
  描述：

  二苯并呋喃 在 palladium on activated charcoal 硝酸 、 一水合肼 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 溶剂黄146 为溶剂， 反应 20.17h， 生成 2,2-dimethyl-N-{8-oxatricyclo[7.4.0.0^2,7]trideca-1(13),2(7),3,5,9,11-hexaen-5-yl}propanamide
  参考文献：
  名称：

  摘要：

  2-, 3- and 4-Pivaloylamino derivatives of dibenzofuran [compounds (5), (4) and (6), respectively] and analogous 3-, 2- and 1-substituted derivatives of 9-methylcarbazole [compounds (8), (7) and (9), respectively] were subjected to lithiation at 0 degreesC and subsequent reaction with dimethylformamide. Aldehyde formation took place at positions alpha to delta to the heteroatom as follows: alpha for (4) and (7); delta for (5); delta and beta (3 : 1) for (8); and alpha' for (6). No formylation occurred with (9).

  DOI：

  10.1071/ch01017

文献信息

• [EN] COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF CARBAZOLE<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE PRODUCTION DE CELLULES SOUCHES HÉMATOPOÏÉTIQUES AMPLIFIÉES AU MOYEN DE DÉRIVÉS DE CARBAZOLE
  申请人：TRANSFUSION HEALTH LLC

  公开号：WO2020223383A1

  公开（公告）日：2020-11-05

  This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CDS 4+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

  本发明涉及一些方面，包括用于维持、增强和扩展来源于一个或多个CD34+细胞的造血干细胞的化合物、方法、系统和组合物。CD34+细胞的来源包括骨髓、脐带血、动员的外周血和非动员的外周血。本文还提供了一些符合式I的化合物，这些化合物在维持、增强和扩展造血干细胞方面是有用的。
• ——
  作者：Leslie W. Deady、Robert M. D. Sette

  DOI：10.1071/ch01017

  日期：——

  2-, 3- and 4-Pivaloylamino derivatives of dibenzofuran [compounds (5), (4) and (6), respectively] and analogous 3-, 2- and 1-substituted derivatives of 9-methylcarbazole [compounds (8), (7) and (9), respectively] were subjected to lithiation at 0 degreesC and subsequent reaction with dimethylformamide. Aldehyde formation took place at positions alpha to delta to the heteroatom as follows: alpha for (4) and (7); delta for (5); delta and beta (3 : 1) for (8); and alpha' for (6). No formylation occurred with (9).