1-[(1E)-1-丙烯-1-基]吡咯烷 | 13937-88-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-[(1E)-1-丙烯-1-基]吡咯烷
• 英文名称: 1-propenyl-pyrrolidine
• 英文别名: 1-ξ-propenyl-pyrrolidine；1-ξ-Propenyl-pyrrolidin；1-prop-1-enylpyrrolidine
• CAS: 13937-88-7
• 化学式: C₇H₁₃N
• 分子量: 111.187
• InChiKey: KORJOGPPKPWOLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  3-Methyl-1-nitro-4-pyrrolidino-1,3-butadien 、 1-[(1E)-1-丙烯-1-基]吡咯烷 生成 5-硝基间二甲苯
  参考文献：
  名称：

  Severin,T.; Ipach,I., Chemische Berichte, 1976, vol. 109, p. 3541 - 3546

  摘要：

  DOI：
• 作为产物：
  描述：

  四氢吡咯 、 丙醛 在 potassium carbonate 作用下， 以 甲苯 为溶剂， 反应 12.0h， 生成 1-[(1E)-1-丙烯-1-基]吡咯烷
  参考文献：
  名称：

  From Phenols to Azulenes: An Extended and Versatile Route to Polyalkylated Azulenes with Variable Substitution Patterns at the Seven- and Five-membered Ring

  摘要：

  通过动态气相热异构化（DGPTI）将多烷基苯基丙醇酸酯转化为多烷基环庚基[b]呋喃-2(2H)-酮，可以轻松制备多烷基化偶氮烯。后者与烯醇醚或烯胺发生热反应，生成相应的偶氮烯。烯胺可由相应的酰胺类物质就地生成，尤其是在由于烯胺的高反应性而难以获得纯烯胺的情况下。

  DOI：

  10.1055/s-2002-25363

文献信息

• Cycloadditions in syntheses. XXXVII. Syntheses of 6-trifluoromethyl-1,2,4-triazines and -1,2,4-triazin-5-ones and their pericyclic reactions with olefins.
  作者：NOBUYA KATAGIRI、HIROSHI WATANABE、CHIKARA KANEKO

  DOI：10.1248/cpb.36.3354

  日期：——

  6-Trifluoromethyl-1, 2, 4-triazines and -1, 2, 4-triazin-5-ones were synthesized to investigate the role of the trifluoromethyl group in their thermal as well as photochemical cycloaddition reactions with olefins. In photochemical 2+2 cycloaddition using the triazin-5-ones and -3, 5-diones, the activation of the imine function by the trifluoromethyl group is demonstrated and a new route to azetidine derivatives having a trifluoromethyl group is disclosed. In thermal 4+2 cycloaddition using the corresponding triazines, acceleration of the so-called inverse electron demand Diels-Alder reaction is demonstrated. Clarification of the mechanisms of these reactions and their use in the synthesis of azetidin-2-ones and pyridines having a trifluoromethyl group are also described.

  6-三氟甲基-1,2,4-三嗪和-1,2,4-三嗪-5-酮被合成，以研究三氟甲基在其与烯烃的热和光化学环加成反应中的作用。在光化学2+2环加成反应中使用三嗪-5-酮和-3,5-二酮时，通过三氟甲基对亚胺功能的活化得以展现，并揭示了一条通向含有三氟甲基的氮杂环丁烷衍生物的新途径。在热4+2环加成反应中使用相应三嗪时，证明了所谓的逆电子需求狄尔斯-阿尔德反应的加速。这些反应的机制澄清及其在合成含有三氟甲基的氮杂环丁烷-2-酮和吡啶中的应用也被描述。
• 1,3-Dipolar Cycloaddition Reaction of Vinyl Azides with Enamines. Synthesis of Vinyltriazolines and Vinyltriazoles
  作者：Yujiro Nomura、Yoshito Takeughi、Shuji Tomoda、Masato M. Ito

  DOI：10.1246/bcsj.54.261

  日期：1981.1

  Reaction of α- and β-azidostyrene with enamines gave vinyltriazolines regioselectively in moderate yields. 1-Pyrrolidinyl enamines reacted with α-azidostyrene more readily than piperidino or morpholino enamines. β-Azidostyrene was as reactive as azidobenzene while α-azidostyrene was much less reactive. Vinyltriazolines formed from enamines of ketones were deaminated to yield the corresponding vinyltriazoles

  α-和β-叠氮苯乙烯与烯胺反应以中等产率区域选择性地得到乙烯基三唑啉。1-吡咯烷基烯胺比哌啶基或吗啉代烯胺更容易与 α-叠氮苯乙烯反应。β-叠氮苯乙烯的反应性与叠氮苯一样，而 α-叠氮苯乙烯的反应性要低得多。由酮的烯胺形成的乙烯基三唑啉脱氨基得到相应的乙烯基三唑。
• Synthesis of New 4,4a-Dihydroxanthones via [4+2]-Cycloaddition Reaction
  作者：N. M. Chernov、T. V. Moroz、R. V. Shutov、N. N. Kuz’mich、A. E. Shchegolev、M. V. Sopova、I. P. Yakovlev

  DOI：10.1134/s1070363219120223

  日期：2019.12

  The effect of electronic properties of substituents in the reactants on the [4+2]-cycloaddition of 3-vinyl-chromen-4-ones (dienes) and N-vinylpyrrolidines (dienophiles) has been studied. The conditions determining the formation of 4,4a-dihydroxanthones or benzophenones as the major products have been found. The aromatization of 4,4a-dihydroxanthones via pyran ring opening has been interpreted by quantum

  已经研究了反应物中取代基的电子性质对3-乙烯基色烯-4-酮（二烯）和N-乙烯基吡咯烷酮（二亲亲烯）的[4 + 2]-环加成的影响。已经发现确定形成4,4a-二氢黄嘌呤或二苯甲酮作为主要产物的条件。通过吡喃开环将4,4a-二氢氧杂蒽芳构化已通过量子化学计算进行了解释。已分离出一系列新的4,4a-二氢黄酮和二苯甲酮衍生物。
• Synthesis of vinca alkaloids and related compounds LXXXV. Studies with azepino[3,4-<i>b</i>]indoles
  作者：Andràs Dancsó、Mária Kajtár-Peredy、Csaba Szántay

  DOI：10.1002/jhet.5570340430

  日期：1997.7

  The synthesis of some new pyrido[1′,2′:1,2]azepino[3,4-b]indoles starting from indole-3-propanamine 1 is described. Stereochemistry and observed side reactions are discussed.

  描述了从吲哚-3-丙胺1开始合成一些新的吡啶并[1'，2'：1,2] azepino [3,4- b ]吲哚。讨论了立体化学和观察到的副反应。
• HETEROAROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR AGONIST BIOLOGICAL ACTIVITY
  申请人：Beard Richard L.

  公开号：US20080064872A1

  公开（公告）日：2008-03-13

  A novel compound having agonist activity at the S 1 P 3 receptor which is represented by the formula I wherein X is selected from the group consisting of CR 3 , N and NO; Y is selected from the group consisting of CR 3 , N and NO; Z is selected from the group consisting of CR 3 , N and NO; and at least one of X, Y and Z is N or NO; V is O or NOR 4 R 1 is an aryl group; R 2 is an aryl group; R 3 is selected from the group consisting of H and alkyl; and 2 of said R 3 groups may together form a cyclic alkyl ring having from 3 to 6 carbon atoms; R 4 is selected from the group consisting of H and alkyl; a is 0 or an integer of from 1 to 6; b is 0 or 1; c is 0 or 1; f is 0 or an integer of 1 or 2; x is 0 or 1; y is 0 or an integer of from 1 to 3; and z is 0 or an integer of from 1 to 3.

  一种具有S1P3受体激动剂活性的新型化合物，其化学式为I，其中X选自CR3，N和NO组成的群体；Y选自CR3，N和NO组成的群体；Z选自CR3，N和NO组成的群体；并且X、Y和Z中至少有一个是N或NO；V是O或NOR4；R1是芳基基团；R2是芳基基团；R3选自H和烷基；其中2个R3基团可以共同形成具有3至6个碳原子的环烷基环；R4选自H和烷基；a为0或1至6的整数；b为0或1；c为0或1；f为0或1或2的整数；x为0或1；y为1至3的整数；z为0或1至3的整数。