(4R)-4-phenyl-2-[2-phenylmethoxy-3-[(4R)-4-phenyl-3-[(2,4,6-trimethoxyphenyl)methyl]-1,3-oxazolidin-2-yl]propyl]-3-[(2,4,6-trimethoxyphenyl)methyl]-1,3-oxazolidine | 1083419-74-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4R)-4-phenyl-2-[2-phenylmethoxy-3-[(4R)-4-phenyl-3-[(2,4,6-trimethoxyphenyl)methyl]-1,3-oxazolidin-2-yl]propyl]-3-[(2,4,6-trimethoxyphenyl)methyl]-1,3-oxazolidine
• CAS: 1083419-74-2
• 化学式: C₄₈H₅₆N₂O₉
• 分子量: 804.981
• InChiKey: BIHDUZQAXQEQRE-MMKDUQFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  59
• 可旋转键数：
  19
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  89.6
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  2-(2-溴乙基)-1,3-二氧杂环己烷 、 (4R)-4-phenyl-2-[2-phenylmethoxy-3-[(4R)-4-phenyl-3-[(2,4,6-trimethoxyphenyl)methyl]-1,3-oxazolidin-2-yl]propyl]-3-[(2,4,6-trimethoxyphenyl)methyl]-1,3-oxazolidine 在 magnesium 、 水 、 氯化铵 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以8.60 g的产率得到(2R,2'R)-2,2'-[5-benzyloxy-1,9-bis(1,3-dioxan-2-yl)nonane-3(S),7(S)-diamino]bis(2-phenylethanol)
  参考文献：
  名称：

  Concise Total Synthesis of (−)-Deoxocuscohygrine and (−)-Dihydrocuscohygrine

  摘要：

  GraphicsThe concise enantioselective total synthesis of C(2)-asymmetrical (-)-deoxocuscohygrine and (-)-dihydrocuscohygrine are described. Double-diastereoselective additions of normal Grignard reagent to bis(1.3-oxazolidine) have been deployed to construct chiral diamine fragments as a key step.

  DOI：

  10.1021/jo801700f
• 作为产物：
  描述：

  3-(benzyloxy)pentanedialdehyde 、 (R)-N-2,4,6-trimethoxybenzylphenylglycinol 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 (4R)-4-phenyl-2-[2-phenylmethoxy-3-[(4R)-4-phenyl-3-[(2,4,6-trimethoxyphenyl)methyl]-1,3-oxazolidin-2-yl]propyl]-3-[(2,4,6-trimethoxyphenyl)methyl]-1,3-oxazolidine
  参考文献：
  名称：

  Concise Total Synthesis of (−)-Deoxocuscohygrine and (−)-Dihydrocuscohygrine

  摘要：

  GraphicsThe concise enantioselective total synthesis of C(2)-asymmetrical (-)-deoxocuscohygrine and (-)-dihydrocuscohygrine are described. Double-diastereoselective additions of normal Grignard reagent to bis(1.3-oxazolidine) have been deployed to construct chiral diamine fragments as a key step.

  DOI：

  10.1021/jo801700f

文献信息

• Concise Total Synthesis of (−)-Deoxocuscohygrine and (−)-Dihydrocuscohygrine
  作者：Takayasu Yamauchi、Sachi Hagiwara、Kimio Higashiyama

  DOI：10.1021/jo801700f

  日期：2008.12.19

  GraphicsThe concise enantioselective total synthesis of C(2)-asymmetrical (-)-deoxocuscohygrine and (-)-dihydrocuscohygrine are described. Double-diastereoselective additions of normal Grignard reagent to bis(1.3-oxazolidine) have been deployed to construct chiral diamine fragments as a key step.