N,O-diacetyl-2-chlorophenylhydroxylamine | 113103-39-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,O-diacetyl-2-chlorophenylhydroxylamine
• 英文别名: N-(acetyloxy)-N-(2-chlorophenyl) acetamide；N-(Acetyloxy)-N-(2-chlorophenyl)acetamide；(N-acetyl-2-chloroanilino) acetate
• CAS: 113103-39-2
• 化学式: C₁₀H₁₀ClNO₃
• 分子量: 227.647
• InChiKey: PIMGLRPSFYLQDE-UHFFFAOYSA-N

物化性质

• 沸点：
  104-107 °C(Press: 0.09 Torr)
• 密度：
  1.315±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙酸酐 、 硝基氯苯 在 甲醇 、 indium(III) chloride 、 indium 作用下， 以 氯仿 为溶剂， 反应 44.0h， 以95%的产率得到N,O-diacetyl-2-chlorophenylhydroxylamine
  参考文献：
  名称：

  INDIUM MEDIATED REDUCTIVE ACYLATIONS OF NITROARENES TOWARDSN,O-DIACYLATEDN-ARYLHYDROXYLAMINES^*

  摘要：

  By applying indium, Ac2O, MeOH, and catalytic amount of InCl3 in CHCl3 solution, nitroarenes were transformed into N,O-diacylated N-arythydroxylamines in moderate to excellent yields.

  DOI：

  10.1081/scc-100107004

文献信息

• Catalyst-free generation of acyl radicals induced by visible light in water to construct C–N bonds
  作者：Maogang Ran、Jiaxin He、Boyu Yan、Wenbo Liu、Yi Li、Yunfen Fu、Chao-Jun Li、Qiuli Yao

  DOI：10.1039/d0ob02364g

  日期：——

  for the direct generation of acyl radicals from α-diketones, and its selective conversion of nitrosoarenes to hydroxyamides or amides with AcOH or NaCl as an additive. The reaction was carried out under mild conditions in water with purple LEDs as the light source. A broad scope of substrates was demonstrated. Mechanistic experiments indicate that α-diketones cleave to give acyl radicals, with hydroxyamides

  我们在这里描述了无催化剂和氧化还原中性的光化学策略，用于直接从α-二酮生成酰基自由基，以及将亚硝基芳烃选择性转化为羟酰胺或酰胺，并以AcOH或NaCl作为添加剂的方法。该反应在温和的条件下在水中以紫色LED为光源进行。展示了广泛的基板范围。机理实验表明，α-二酮裂解产生酰基，而羟酰胺被进一步还原为酰胺。
• WAGENKNECHT, J. H.;JOHNSON, G. V., J. ELECTROCHEM. SOC., 134,(1987) N 11, 2754-2761
  作者：WAGENKNECHT, J. H.、JOHNSON, G. V.

  DOI：——

  日期：——
• INDIUM MEDIATED REDUCTIVE ACYLATIONS OF NITROARENES TOWARDS<i>N,O</i>-DIACYLATED<i>N</i>-ARYLHYDROXYLAMINES^*
  作者：Byeong Hyo Kim、Jae Wook Cheong、Rongbi Han、Young Moo Jun、Woonphil Baik、Byung Min Lee

  DOI：10.1081/scc-100107004

  日期：2001.1

  By applying indium, Ac2O, MeOH, and catalytic amount of InCl3 in CHCl3 solution, nitroarenes were transformed into N,O-diacylated N-arythydroxylamines in moderate to excellent yields.