3-phenoxy-benzamidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenoxy-benzamidine
• 英文别名: 3-Phenoxy-benzamidin；3-Phenoxybenzene-1-carboximidamide；3-phenoxybenzenecarboximidamide
• 化学式: C₁₃H₁₂N₂O
• 分子量: 212.251
• InChiKey: CEHNDHNQFURQOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  potassium phenolate 在 乙醚 、 氨 、 sodium 、 铜 作用下， 生成 3-phenoxy-benzamidine
  参考文献：
  名称：

  Prevalence of silent celiac disease in patients with autoimmune thyroiditis from Northern Sardinia

  摘要：

  Celiac disease (CD) is frequently associated with other autoimmune diseases such as Type 1 diabetes mellitus, autoimmune thyroiditis (AT), and Addison's disease. The frequency of these associations varies with the populations studied. We conducted this study to ascertain the prevalence of CD in patients with AT from Sardinia, an area with a very high prevalence of CD. To this aim, 297 consecutive patients with AT (as defined by elevated antithyroid antibody levels and a positive ultrasound scan) were studied. Immunoglobulin A and G-class antigliadin antibodies were assayed in serum; if either or both were positive, antiendomysium antibodies were determined. If two markers were positive, serum ferritin, folate, and vitamin B12 levels were measured and jejunal biopsy was suggested. Thirteen out of the 14 patients who showed at least two positive markers consented to jejunal biopsy and all of them showed histological features of CD. The prevalence of CD in AT patients was 4-fold greater than that observed in the general population (4.37 vs 1.06%, p <0.0001). Ferritin was low in 6 and vitamin B12 in 2 out of 13 patients; serum folates were normal in all patients. Molecular typing of HLA class II alleles showed an increased frequency of the extended haplotype DRB1*0301/DQA1*0501/DQB1*0201. None of our patients had a history of gastrointestinal symptoms. We confirm the increased prevalence of silent CD in patients with AT. Patients with AT ought to be regarded as a highrisk group for CD and should be screened routinely for it; if negative, screening tests should be repeated at regular intervals.

  DOI：

  10.1007/bf03343864

文献信息

• Design, synthesis and evaluation of potential inhibitors of HIV gp120–CD4 interactions
  作者：Cyrille Boussard、Thomas Klimkait、Naheed Mahmood、Martin Pritchard、Ian H. Gilbert

  DOI：10.1016/j.bmcl.2004.02.091

  日期：2004.5

  This paper describes an approach to prevent HIV-cell fusion by disrupting the interaction between HIV protein gp120 and CD4 receptor. The CD4 residues Phe43 and Arg59 make important interactions with gp120. Small molecule analogues were made to mimic the crucial features of these residues. The analogues were assayed using a cellular 'FIGS' assay to measure inhibition of cell fusion and caused some inhibition. (C) 2004 Elsevier Ltd. All rights reserved.