2-methyl-1-(4-piperidinyl)-1H-benzoimidazole hydrochloride | 550370-61-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-methyl-1-(4-piperidinyl)-1H-benzoimidazole hydrochloride
• 英文别名: 2-methyl-1-piperidin-4-yl-1H-benzimidazole hydrochloride；2-methyl-1-piperidin-4-ylbenzimidazole;hydrochloride
• CAS: 550370-61-1
• 化学式: C₁₃H₁₇N₃*ClH
• 分子量: 251.759
• InChiKey: IXNAAOBQUXTJHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.69
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  29.8
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methyl-1-(4-piperidinyl)-1H-benzoimidazole hydrochloride 、 4-氯异硫氰酸苯酯 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 N-(4-chlorophenyl)-4-(2-methyl-1H-benzo[d]imidazol-1-yl)piperidine-1-carbothioamide
  参考文献：
  名称：

  WO2006/114706

  摘要：

  公开号：
• 作为产物：
  描述：

  4-(2-methyl-1H-benzimidazol-1-yl)piperidine 在 盐酸 作用下， 以 水 为溶剂， 反应 3.0h， 生成 2-methyl-1-(4-piperidinyl)-1H-benzoimidazole hydrochloride
  参考文献：
  名称：

  Compounds with antiparasitic activity, applications thereof to the treatment of infectious diseases caused by apicomplexans

  摘要：

  这项发明涉及具有抗寄生虫活性的化合物，以及它们作为药物的用途，特别是作为预防和/或治疗由顶复合体寄生虫引起的寄生虫病的药物。该发明还涉及含有这些化合物的药物组合物。

  公开号：

  EP1997805A1

文献信息

• Piperidines
  申请人：Icagen, Inc.

  公开号：US20030171360A1

  公开（公告）日：2003-09-11

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides substituted piperidines, and compositions containing these compounds. Also provided are methods using the compounds of the invention for the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

  提供了一种在治疗疾病中通过抑制电压依赖性钠通道的钠离子通量而有用的化合物、组合物和方法。更具体地，该发明提供了取代哌啶类化合物以及含有这些化合物的组合物。还提供了使用该发明的化合物治疗中枢或外周神经系统疾病的方法，特别是通过阻断与所示疾病的发作或复发有关的钠通道来治疗疼痛和慢性疼痛。本发明的化合物、组合物和方法特别适用于通过抑制包含PN3亚基的通道的离子通量来治疗神经病性或炎症性疼痛。
• Inhibitors of akt activity
  申请人：Bilodeau T Mark

  公开号：US20060205765A1

  公开（公告）日：2006-09-14

  The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

  本发明涉及化合物，其包含一个五元杂环环并到一个取代吡啶基团上，能够抑制Akt，一种丝氨酸/苏氨酸蛋白激酶的活性。本发明进一步涉及包含本发明化合物的化疗组合物，并且涉及使用本发明化合物治疗癌症的方法。
• Compounds Useful In Therapy
  申请人：Bryans Justin Stephen

  公开号：US20080188478A1

  公开（公告）日：2008-08-07

  Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R 1 represents a group selected from H, CF 3 , and C 1-6 alkyl (optionally substituted by C 1-6 alkyloxy or triazolyl); R 2 represents halo; Ring A represents a 5- or 6-membered heterocyclic ring containing at least one N atom (the ring being optionally bridged with two or more carbon atoms); R 3 represents a 5- or 6-membered heterocyclic ring containing at least one atom selected from N, O or S, the heterocyclic ring being optionally substituted by one or more groups selected from C 1-6 alkyl oxo or NH 2 , the heterocyclic ring being further optionally fused to a 5- or 6-membered aryl or heterocyclic ring containing at least one atom selected from N, O or S, the fused aryl or heterocyclic ring being substituted by one or more halo atoms; are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhea.

  式(I)的化合物或其药学上可接受的衍生物，其中： R1表示从H，CF3和C1-6烷基（可选地被C1-6烷氧基或三唑基取代）中选择的基团； R2表示卤素； 环A表示含有至少一个N原子的5-或6成员杂环，（该环可与两个或更多个碳原子桥接）； R3表示含有至少一个从N，O或S中选择的原子的5-或6成员杂环，该杂环可被选自C1-6烷基氧或NH2的一个或多个基团取代，该杂环进一步可融合到一个含有至少一个从N，O或S中选择的原子的5-或6成员芳香族或杂环中，该融合的芳香族或杂环被一个或多个卤素原子取代； 用于治疗需要V1a拮抗剂的疾病，特别是痛经。
• PIPERIDINES
  申请人：Gross F. Michael

  公开号：US20080058376A1

  公开（公告）日：2008-03-06

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides substituted piperidines, and compositions containing these compounds. Also provided are methods using the compounds of the invention for the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

  本发明提供了用于通过抑制电压依赖性钠通道中的钠离子通量来治疗疾病的化合物、组合物和方法。更具体地，本发明提供了取代哌啶的化合物和含有这些化合物的组合物。还提供了使用本发明的化合物治疗中枢或外周神经系统障碍，特别是疼痛和慢性疼痛的方法，通过阻断与所述病症的发作或复发相关的钠通道。本发明的化合物、组合物和方法特别适用于通过抑制包括PN3亚单位的通道中的离子通量来治疗神经病理性或炎症性疼痛。
• Inhibitors of Akt activity
  申请人：Merck & Co., Inc.

  公开号：US07638530B2

  公开（公告）日：2009-12-29

  The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

  本发明涉及一种含有五元杂环环并取代吡啶基团的化合物，该化合物抑制Akt，一种丝氨酸/苏氨酸蛋白激酶的活性。本发明还涉及含有本发明化合物的化疗组合物以及使用本发明化合物治疗癌症的方法。