3-(三氯锗)丙酰氯 | 15961-24-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 中文名称: 3-(三氯锗)丙酰氯
• 英文名称: β-trichlorogermylpropionyl chloride
• 英文别名: 3-(trichlorogermyl)propionyl chloride；trichlorogermyl propionyl chloride；3-Trichlorgermyl-propionsaeurechlorid；Propanoyl chloride, 3-(trichlorogermyl)-；3-trichlorogermylpropanoyl chloride
• CAS: 15961-24-7
• 化学式: C₃H₄Cl₄GeO
• 分子量: 270.466
• InChiKey: VWHUZNBSDQCMRD-UHFFFAOYSA-N

物化性质

• 熔点：
  70-72 °C(Solv: dichloromethane (75-09-2))
• 沸点：
  89-91°C/7mmHg
• 密度：
  1.751

计算性质

• 辛醇/水分配系数(LogP)：
  2.08
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• TSCA：
  Yes
• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  3-(三氯锗)丙酰氯 生成 N-phenyl-3-trichlorogermylpropanamide
  参考文献：
  名称：

  TAKADA, TOEXIRO;KAKIMOTO, NORIXIRO

  摘要：

  DOI：
• 作为产物：
  描述：

  羧基乙基三氯锗烷 生成 3-(三氯锗)丙酰氯
  参考文献：
  名称：

  KAKIMOTO, NORIXIRO;JOSIXARA, TORU;AKIBA

  摘要：

  DOI：

文献信息

• Quinolyl organic germanium ester and the synthesis method thereof
  申请人：Qu Xiaogang

  公开号：US20050282795A1

  公开（公告）日：2005-12-22

  The present invention relates to compounds of quinolyl organic germanium ester having the following Formula 1 and the synthesis methods thereof. R 1 and R 2 are defined in the specification. Organic germanium acyl chloride and 8-hydroxylquinoline were used as the starting raw materials. Displacement reaction was carried out at 0-40° C., followed by hydrolysis reaction and then by changing the solvent, water soluble quinolyl organic germanium ester was finally obtained. The quinolyl organic germanium ester possesses better water solubility and fat solubility. Due to the existence of both drug active group (organic germanium part) and drug recognizing group (quinoline part) in the structure of the quinolyl organic germanium ester, the compound is expected to develop a novel kind of anti-tumor drug.

  本发明涉及具有以下式1的喹啉基有机锗酯化合物及其合成方法。其中R1和R2在规范中定义。有机锗酰氯和8-羟基喹啉被用作起始原料。在0-40℃下进行取代反应，随后进行水解反应，然后通过改变溶剂，最终得到了水溶性喹啉基有机锗酯。喹啉基有机锗酯具有更好的水溶性和脂溶性。由于喹啉基有机锗酯结构中同时存在药物活性基团（有机锗部分）和药物识别基团（喹啉部分），因此该化合物有望开发出一种新型的抗肿瘤药物。
• Mironov, V. F.; Nuridzhanyan, A. K.; Feoktistov, A. E., Journal of general chemistry of the USSR, 1990, vol. 60, p. 125 - 127
  作者：Mironov, V. F.、Nuridzhanyan, A. K.、Feoktistov, A. E.

  DOI：——

  日期：——
• Feoktistov, A. E.; Mironov, V. F., Journal of general chemistry of the USSR, 1986, vol. 56, p. 2288 - 2291
  作者：Feoktistov, A. E.、Mironov, V. F.

  DOI：——

  日期：——
• Acylamides of C-germylcarboxylic acids. Crystal and molecular structure of N-acetyl-N-methyl-3-(trichlorogermyl)propionamide
  作者：A. K. Nuridzhanyan、S. N. Gurkova、A. I. Gusev、V. F. Mironov

  DOI：10.1007/bf00704014

  日期：1993.4

  The first representatives of a new class of organogermanium compounds, the acylamides of C-germylcarboxylic acids, N-acetyl-N-methyl-3-(trichlorogermyl)propionamide and N-3-(trichlorogermyl)propionylurethane, were synthesized. An X-ray structural study of Cl3GeCH2CH2C(O)NMeC(O)Me revealed a greater Ge...O intramolecular distance than that reported earlier for 3-(trichlorogermyl)propionamides. The Ge atom configuration is somewhat distorted towards a trigonal bipyramid.
• SHANGGUAN, GUOQIANG;ZHANG, SHUGONG;NI, JIAZUAN;NIE, YUXIU, INYUN XUASYUEH, 6,(1989) N, S. 59-62
  作者：SHANGGUAN, GUOQIANG、ZHANG, SHUGONG、NI, JIAZUAN、NIE, YUXIU

  DOI：——

  日期：——