2-bromo-3,5-dimethoxy-1,4-dimethyl-benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromo-3,5-dimethoxy-1,4-dimethyl-benzene
• 英文别名: 2-Brom-3,5-dimethoxy-1,4-dimethyl-benzol；3-Brom-2.6-dimethoxy-p-xylol；4-Bromo-1,3-dimethoxy-2,5-dimethylbenzene
• 化学式: C₁₀H₁₃BrO₂
• 分子量: 245.116
• InChiKey: FLVGSJAZHFOINF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bromo-3,5-dimethoxy-1,4-dimethyl-benzene 在 三氯化铝 、 苯 作用下， 生成 2,5-dimethyl-4-phenoxy-resorcinol
  参考文献：
  名称：

  Model evaluation based on residual analysis of two similar models

  摘要：

  Models that may appear to have different properties may in fact produce residuals that differ only in subtle ways. By analysing the relationships between model residuals the problems in distinguishing between models can perhaps be discovered: as illustrated by the econometric examples considered. Regressing residuals gives the long-memory residual, which is the difference between two models, but this difference is very subtle and deeply hidden, which explains why the traditional standard technique does not find this difference.

  DOI：

  10.1080/000368400322192
• 作为产物：
  描述：

  1,3-二甲氧基-2,5-二甲基苯 在 溴 、 溶剂黄146 作用下， 生成 2-bromo-3,5-dimethoxy-1,4-dimethyl-benzene
  参考文献：
  名称：

  Asahina; Asano, Chemische Berichte, 1933, vol. 66, p. 1215

  摘要：

  DOI：

文献信息

• 2-Aminopurine Analogs Having HSP90-Inhibiting Activity
  申请人：Kasibhatla Rao Srinivas

  公开号：US20070185064A1

  公开（公告）日：2007-08-09

  2-Aminopurine analogs are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Method of synthesis and use of such compounds are also described and claimed.

  本文描述了2-氨基嘌呤类似物，并证明或预测其在治疗和预防各种HSP90介导的疾病（如增生性疾病）中作为HSP90抑制剂具有实用价值。还描述和声称了这种化合物的合成方法和使用方法。