5,5-Diphenyl-thiazolidin-dion-(2,4) | 4695-04-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5,5-Diphenyl-thiazolidin-dion-(2,4)
• 英文别名: 5,5-Diphenyl-2,4-diketothiazolidin；5,5-Diphenyl-thiazolidon-2,4-dion；5,5-diphenyl-thiazolidine-2,4-dione；5,5-Diphenyl-thiazolidin-2,4-dion；5,5-Diphenyl-1,3-thiazolidine-2,4-dione；5,5-diphenyl-1,3-thiazolidine-2,4-dione
• CAS: 4695-04-9
• 化学式: C₁₅H₁₁NO₂S
• 分子量: 269.324
• InChiKey: MHGUXTYLCIVWSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  正溴丁烷 、 5,5-Diphenyl-thiazolidin-dion-(2,4) 生成 3-丁基-5,5-二苯基-噻唑烷-2,4-二酮
  参考文献：
  名称：

  Fünfgliedrige, pharmakologisch wirksame Heterocyclen

  摘要：

  DOI：

  10.1002/ardp.19572901105
• 作为产物：
  描述：

  methyl chlorodiphenylacetate 在 盐酸 作用下， 以 乙醇 、 正丁醇 为溶剂， 反应 22.0h， 生成 5,5-Diphenyl-thiazolidin-dion-(2,4)
  参考文献：
  名称：

  Studies on antidiabetic agents. III. 5-Arylthiazolidine-2,4-diones as potent aldose reductase inhibitors.

  摘要：

  具有一个或两个取代基（如苯基、杂基和烷基）的噻唑烷-2,4-二酮衍生物在5位合成并评估为醛糖还原酶抑制剂。在鼠晶状体培养检测中，活性化合物的抑制作用也被测量。在这些化合物中，一系列5-(3,4-二烷氧基苯基)噻唑烷-2,4-二酮在两种检测中显示出显著的活性。结构-活性关系进行了讨论，并描述了一种合成5-芳基噻唑烷-2,4-二酮的新方法。

  DOI：

  10.1248/cpb.30.3601

文献信息

• Dannenberg; Rahman, Chemische Berichte, 1956, vol. 89, p. 1625,1633
  作者：Dannenberg、Rahman

  DOI：——

  日期：——
• Wheeler; Johnson, Journal of the American Chemical Society, 1902, vol. 24, p. 690
  作者：Wheeler、Johnson

  DOI：——

  日期：——
• Protein p140 and DNA encoding it
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0659883B1

  公开（公告）日：2003-04-16
• Novel polypeptide of protein p140 and DNAs encoding it
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US20030170865A1

  公开（公告）日：2003-09-11

  The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment for the currently said the prevention and/or treatment method; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylation of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only improve the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
• US5506205A
  申请人：——

  公开号：US5506205A

  公开（公告）日：1996-04-09