2-hydroxyethyl pyridine-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-hydroxyethyl pyridine-4-carboxylate
• 化学式: C₈H₉NO₃
• 分子量: 167.164
• InChiKey: KGYXVVZOCYLHBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-[1,3]dioxolan-2-yl-pyridine 在 蒽醌-2-羧酸 、 氧气 作用下， 以 乙酸乙酯 为溶剂， 反应 24.0h， 以7%的产率得到2-hydroxyethyl pyridine-4-carboxylate
  参考文献：
  名称：

  使用蒽醌-2-羧酸通过需氧光氧化从环缩醛中快速有效地合成羟烷基酯

  摘要：

  在荧光灯的可见光照射下，各种环状缩醛与分子氧和蒽醌-2-羧酸的便利的无金属氧化方案，得到了它们相应的羟烷基酯。

  DOI：

  10.1016/j.tetlet.2015.02.104

文献信息

• THIAZOLIDINONE COMPOUNDS AND USE THEREOF
  申请人：National Health Research Institutes

  公开号：US20170253569A1

  公开（公告）日：2017-09-07

  A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

  一种含有化合物（I）的药物组合物，用于治疗与阿片受体相关的疾病。还公开了一种使用这种化合物治疗阿片受体相关疾病的方法。进一步公开了两组式（I）的噻唑烷酮化合物：（i）每种化合物的对映体过量大于90%；（ii）每种化合物被氘取代。
• Thiazolidinone compounds and use thereof
  申请人：National Health Research Institutes

  公开号：US10544113B2

  公开（公告）日：2020-01-28

  A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

  一种含有用于治疗阿片受体相关疾病的式 (I) 化合物的药物组合物。还公开了一种使用此类化合物治疗阿片受体相关疾病的方法。进一步公开了两组式(I)的噻唑烷酮化合物：(i)对映体过量大于 90%的化合物和(ii)各自被氘取代的化合物。
• JAIN, SANJAY;JAIN, RAHUL;SINGH, JUJHAR;ANAND, NITYA, CHEM. AND IND.,(1990) N8, C. 576
  作者：JAIN, SANJAY、JAIN, RAHUL、SINGH, JUJHAR、ANAND, NITYA

  DOI：——

  日期：——
• [EN] THIAZOLIDINONE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS DE THIAZOLIDINONE ET LEUR UTILISATION
  申请人：SHIH CHUAN

  公开号：WO2017155910A1

  公开（公告）日：2017-09-14

  A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.
• Facile and efficient synthesis of hydroxyalkyl esters from cyclic acetals through aerobic photo-oxidation using anthraquinone-2-carboxylic acid
  作者：Tomoaki Yamaguchi、Yasuhisa Kudo、Shin-ichi Hirashima、Eiji Yamaguchi、Norihiro Tada、Tsuyoshi Miura、Akichika Itoh

  DOI：10.1016/j.tetlet.2015.02.104

  日期：2015.4

  oxidation protocol of various cyclic acetals with molecular oxygen and anthraquinone-2-carboxylic acid under visible light irradiation by a fluorescent lamp afforded their corresponding hydroxyalkyl esters.

  在荧光灯的可见光照射下，各种环状缩醛与分子氧和蒽醌-2-羧酸的便利的无金属氧化方案，得到了它们相应的羟烷基酯。