2-methyl-5,6,7,8-tetrahydro-1H-naphtho[2,3-d]imidazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-methyl-5,6,7,8-tetrahydro-1H-naphtho[2,3-d]imidazole
• 英文别名: 2-methyl-5,6,7,8-tetrahydro-1H-naphth[2,3-d]imidazole；2-Methyl-5,6,7,8-tetrahydro-1H-naphth[2,3-d]imidazol；2-methyl-5,6,7,8-tetrahydro-1H-benzo[f]benzimidazole
• 化学式: C₁₂H₁₄N₂
• 分子量: 186.257
• InChiKey: UWSYQYCXJAYMNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氨基-3-硝基-5,6,7,8-四氢萘 在 氢气 、 镍 、 溶剂黄146 、 萘烷 作用下， 生成 2-methyl-5,6,7,8-tetrahydro-1H-naphtho[2,3-d]imidazole
  参考文献：
  名称：

  DE333157

  摘要：

  公开号：

文献信息

• Benzimidazole Derivatives And Their Pharmaceutical Compositions And Uses
  申请人：Huang Zhenhua

  公开号：US20130023568A1

  公开（公告）日：2013-01-24

  The present invention relates to benzimidazole derivatives and their pharmaceutical compositions and uses, specifically to benzimidazole derivatives of Formula (I), or their stereoisomer, pharmaceutically acceptable salt or solvates thereof, in which R 1 , R 2 , R 3 , R 4 , R 5 and n have the definitions in the description; the present invention further relates to a pharmaceutical composition containing the compounds, methods for preparing the compounds, and use of the compounds for manufacturing of a medicament for prophylaxis and/or treatment of peptic ulcer, ulcer hemorrhage and diseases associated with gastric acid.

  本发明涉及苯并咪唑衍生物及其制药组合物和用途，具体涉及公式（I）的苯并咪唑衍生物或其立体异构体、药学上可接受的盐或溶剂，其中R1、R2、R3、R4、R5和n在说明书中有定义；本发明还涉及含有该化合物的制药组合物、制备该化合物的方法以及利用该化合物制造用于预防和/或治疗消化性溃疡、溃疡出血和与胃酸有关的疾病的药物的用途。
• BENZIMIDAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES
  申请人：Xuanzhu Pharma Co., Ltd.

  公开号：US20160176892A1

  公开（公告）日：2016-06-23

  The present invention relates to benzimidazole derivatives and their pharmaceutical compositions and uses, specifically to benzimidazole derivatives of Formula (I), or their stereoisomer, pharmaceutically acceptable salt or solvates thereof, in which R 1 , R 2 , R 3 , R 4 , R 5 and n have the definitions in the description; the present invention further relates to a pharmaceutical composition containing the compounds, methods for preparing the compounds, and use of the compounds for manufacturing of a medicament for prophylaxis and/or treatment of peptic ulcer, ulcer hemorrhage and diseases associated with gastric acid.

  本发明涉及苯并咪唑衍生物及其制药组合物和用途，具体涉及公式（I）的苯并咪唑衍生物或其立体异构体，其药学上可接受的盐或溶剂，其中R1、R2、R3、R4、R5和n在说明中有定义；本发明还涉及含有该化合物的制药组合物，制备该化合物的方法，以及将该化合物用于制造预防和/或治疗消化性溃疡、溃疡出血和与胃酸有关的疾病的药物的用途。
• DE333157
  申请人：——

  公开号：——

  公开（公告）日：——
• SUBSTITUTED HOMOPIPERIDINYL BENZIMIDAZOLE ANALOGUES AS FUNDIC RELAXANTS
  申请人：Janssen Pharmaceutica NV

  公开号：EP1250337B1

  公开（公告）日：2008-12-03
• US7304052B2
  申请人：——

  公开号：US7304052B2

  公开（公告）日：2007-12-04