(S)-(+)-2,2'-[2-(2,2-diphenyl-2-hydroxyethyl)-2-azapropane-1,3-diyl]-1,1'-binaphthalene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-(+)-2,2'-[2-(2,2-diphenyl-2-hydroxyethyl)-2-azapropane-1,3-diyl]-1,1'-binaphthalene
• 英文别名: 2-(13-Azapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-yl)-1,1-diphenylethanol
• 化学式: C₃₆H₂₉NO
• 分子量: 491.632
• InChiKey: ZNGBYQJRRZTAFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  phenylmagnesium bromide 、 alkaline earth salt of/the/ methylsulfuric acid 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 21.0h， 生成 (S)-(+)-2,2'-[2-(2,2-diphenyl-2-hydroxyethyl)-2-azapropane-1,3-diyl]-1,1'-binaphthalene
  参考文献：
  名称：

  1,1′-Binaphthylazepine-based ligands for asymmetric catalysis. Part 1: Preparation and characterization of some new aminoalcohols and diamines

  摘要：

  Starting from (S)-1.1 ' -binaphthol, a series of ten novel enantiopure 1.1 ' -binaphthylazepine-based aminoalcohols and diamines 1a-1j were efficiently prepared and fully characterized. These derivatives, having either only an atropisomeric bridged-binaphthyl backbone or an additional stereogenic carbon center, can be interesting ligands for asymmetric catalysis. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00199-9

文献信息

• 1,1′-Binaphthylazepine-based ligands for asymmetric catalysis. Part 1: Preparation and characterization of some new aminoalcohols and diamines
  作者：Tommaso Mecca、Stefano Superchi、Egidio Giorgio、Carlo Rosini

  DOI：10.1016/s0957-4166(01)00199-9

  日期：2001.5

  Starting from (S)-1.1 ' -binaphthol, a series of ten novel enantiopure 1.1 ' -binaphthylazepine-based aminoalcohols and diamines 1a-1j were efficiently prepared and fully characterized. These derivatives, having either only an atropisomeric bridged-binaphthyl backbone or an additional stereogenic carbon center, can be interesting ligands for asymmetric catalysis. (C) 2001 Elsevier Science Ltd. All rights reserved.