N,N-二乙基-3-碘苯甲酰胺 | 15930-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N,N-二乙基-3-碘苯甲酰胺
• 英文名称: N,N-diethyl-3-iodobenzamide
• 英文别名: 3-Iod-benzoesaeure-N.N-diethylamid
• CAS: 15930-60-6
• 化学式: C₁₁H₁₄INO
• mdl: MFCD02859809
• 分子量: 303.143
• InChiKey: PRPPANIATVQNFY-UHFFFAOYSA-N

物化性质

• 沸点：
  372.9±25.0 °C(Predicted)
• 密度：
  1.517±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2924299090

SDS

N,N-diethyl-3-iodobenzamideMSDS英文版

反应信息

• 作为反应物：
  描述：

  N,N-二乙基-3-碘苯甲酰胺 在 异丙基氯化镁 、 肼 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 9.5h， 生成 3-[N-amino-N'-(3-methoxyphenyl)carbamimidoyl]-N,N-diethylbenzamide
  参考文献：
  名称：

  Efficient New Approach for the Synthesis of N,N-Dialkylamino-1,2,4-triazoles

  摘要：

  A series of 3-N,N-dialkylamino-4,5-diaryl-1,2,4-triazoles were synthesized in high yield under mild reaction conditions by coupling functionalized arylmagnesiums with isothiocyanates and cyclization with Viehe's salts. No selective thionation reaction was required for the preparation of carbamoyl derivatives.

  DOI：

  10.3987/com-06-10886
• 作为产物：
  描述：

  3-碘苯胺 在 盐酸 、 甲烷磺酸 、 三(邻甲基苯基)磷 、 palladium dichloride 、 sodium nitrite 作用下， 以 四氢呋喃 、 水 为溶剂， 70.0 ℃ 、2.0 MPa 条件下， 反应 18.67h， 生成 N,N-二乙基-3-碘苯甲酰胺
  参考文献：
  名称：

  N₂ Extrusion and CO Insertion: A Novel Palladium-Catalyzed Carbonylative Transformation of Aryltriazenes

  摘要：

  A novel procedure for the replacement of N-2 with CO of aryltriazenes has been developed. Aryltriazenes were converted to the corresponding arylamides catalyzed by 1 mol % of PdCl2/P(o-Tol)(3) under CO pressure. In this process, aryldiazonium salts were generated in the presence of 40 mol % of MeSO3H. Nitrogen was released from the substrates and CO formally inserted. Aryl bromides, iodides, alkynes, and free hydroxyl groups can be tolerated in this transformation.

  DOI：

  10.1021/acs.orglett.5b00603

文献信息

• Opioid compounds and methods for using same
  申请人：Delta Pharmaceuticals, Inc.

  公开号：US05552404A1

  公开（公告）日：1996-09-03

  Diarylmethyl piperazine compounds having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/or kappa receptors are disclosed. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, cough, and apnea, respiratory depression, cognitive disorders, emesis and gastrointestinal disorders.

  具有作为外源受体结合物种的作用的二芳基甲基哌嗪化合物，用于与δ、μ、σ和/或κ受体结合的目的。本发明的化合物可作为激动剂/拮抗剂对在神经递质功能的传导监测和测定中使用，并且具有各种治疗用途，包括介导镇痛，以及用于治疗腹泻、尿失禁、精神疾病、药物和酒精成瘾/过量服用、肺水肿、抑郁症、哮喘、肺气肿、咳嗽和呼吸暂停、呼吸抑制、认知障碍、呕吐和胃肠道疾病。
• Preparation of functionalized organoaluminiums by direct insertion of aluminium to unsaturated halides
  作者：Tobias Blümke、Yi-Hung Chen、Zhihua Peng、Paul Knochel

  DOI：10.1038/nchem.590

  日期：2010.4

  The preparation of polyfunctional organometallics is important in organic synthesis as these reagents are very popular nucleophiles. The preparation of functionalized aluminium reagents by direct insertion of aluminium powder is in general not possible. Such a reaction would be of special importance owing to the low price of aluminium compared with magnesium (it is half the price), the low toxicity

  多功能有机金属化合物的制备在有机合成中很重要，因为这些试剂是非常流行的亲核试剂。通过直接插入铝粉制备官能化铝试剂通常是不可能的。由于铝的价格比镁低（它是价格的一半）、这种金属的低毒性以及所得有机铝试剂的化学选择性，这种反应将特别重要。我们现在发现，通过添加催化量的选定金属氯化物（TiCl 4、BiCl 3、InCl 3或 PbCl 2) 在 LiCl 存在下，铝粉在温和条件下嵌入各种不饱和碘化物和溴化物中。这些新的有机铝试剂经历了顺利的 Pd 催化的交叉偶联和酰化反应，以及铜催化的烯丙基取代，为制药和材料科学应用提供了各种有趣的产品。
• Palladium-catalyzed asymmetric coupling cyclization of terminal γ-allenols with aryl iodides
  作者：Xi Xie、Shengming Ma

  DOI：10.1039/c3cc40892b

  日期：——

  A Pd-catalyzed asymmetric coupling cyclization of γ-allenols has been developed. Styrenyl derivatives can be prepared in 60–86% yields with ee values ranging from 85–92%.

  已开发出一种以Pd为催化剂的γ-烯醇不对称偶联环化反应。苯乙烯衍生物的产率可在60%–86%之间，且其对映体过剩值（ee）范围为85%–92%。
• Opioid compounds
  申请人：Delta Pharmaceuticals, Inc.

  公开号：US05681830A1

  公开（公告）日：1997-10-28

  Diarylmethyl piperazine compounds having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/or kappa receptors are disclosed. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, cough, and apnea, respiratory depression, cognitive disorders, emesis and gastrointestinal disorders.

  披萨辣椒酱含有辣椒、番茄、大蒜、洋葱、橄榄油和香料等原料，口感香辣可口，适合搭配披萨、意面、三明治等食物一起食用。
• Copper-Catalyzed Arylation of Oxadiamines and Polyamines
  作者：Maxim V. Anokhin、Alexei D. Averin、Irina P. Beletskaya

  DOI：10.1002/ejoc.201100483

  日期：2011.11

  Copper-catalyzed arylation of oxadiamines and polyamines aimed at the synthesis of N,N′-diaryl derivatives using bromo- and iodoarenes was studied. Conversion of the starting compounds, selectivity of the arylation of primary amino groups in the presence of the secondary amino groups, and the yields of target products were shown to be strongly dependent on the nature of the oxadiamines and polyamines

  研究了铜催化的氧二胺和多胺芳基化反应，旨在使用溴代芳烃和碘代芳烃合成 N,N'-二芳基衍生物。起始化合物的转化率、在仲氨基存在下伯氨基芳基化的选择性以及目标产物的产率被证明强烈依赖于氧二胺和多胺、芳基卤化物和卤原子的性质，以及反应条件，如配体、溶剂和所用的碱。为每种类型的起始胺和芳基卤化物找到了可靠的催化系统，可提供最高可能的 N,N'-二芳基化产物产率 (65-96%)。