(4-Bromophenyl)-chlorodiazene | 127125-47-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Bromophenyl)-chlorodiazene
• CAS: 127125-47-7
• 化学式: C₆H₄BrClN₂
• 分子量: 219.468
• InChiKey: DSFDBJWIYFTGCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4-methoxyphenyl)-1-(4-ethoxyphenyl)propan-1,3-dione 、 (4-Bromophenyl)-chlorodiazene 在 sodium acetate 作用下， 以 丙酮 为溶剂， 以76%的产率得到3-(4-methoxyphenyl)-1-(4-ethoxyphenyl)-2-<(4-bromobenzene)azo>propan-1,3-dione
  参考文献：
  名称：

  Singh, Rajvir; Malik, Om Parkash, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1994, vol. 33, # 5, p. 455 - 459

  摘要：

  DOI：

文献信息

• Synthesis, reactions, and biological activity of 1,4-benzothiazine derivatives
  作者：Eman M. H. Abbas、Thoraya A. Farghaly

  DOI：10.1007/s00706-010-0312-6

  日期：2010.6

  7-Dimethoxy-2H-1,4-benzothiazin-3(4H)-one reacts with dimethylformamide dimethylacetal (DMF-DMA) to give the novel enaminone 2-(dimethylaminomethylene)-6,7-dimethoxy-2H-1,4-benzothiazin-3(4H)-one. The reaction of the latter with various active methylene compounds afforded pyrido[3,2-b][1,4]benzothiazines. Also, coupling of the enaminone with diazotized aniline derivatives gave 2-(arylhydrazono)-6,7-dimethoxy-2H-1

  摘要6,7-二甲氧基-2 H -1,4-苯并噻嗪-3（4 H）-与二甲基甲酰胺二甲基缩醛（DMF-DMA）反应生成新的烯胺基2-（二甲基氨基亚甲基）-6,7-二甲氧基-2 H -1,4-苯并噻嗪-3（4 H）-1 。后者与各种活性亚甲基化合物的反应提供了吡啶并[3，2- b ] [1，4]苯并噻嗪。同样，烯胺酮与重氮化苯胺衍生物的偶合得到2-（芳基肼基）-6,7-二甲氧基-2 H -1,4-苯并噻嗪-3（4 H）-那些。光谱数据表明，后者化合物主要以hydr互变异构形式存在。另外，将烯胺酮与重氮化的杂环胺偶联得到四和五杂环体系。筛选了一些合成化合物的抗肿瘤和抗菌活性。 图形概要
• Synthesis of 1-Arylazo-3-acetyl-1H-cinnolin-4-one Derivatives
  作者：Mohamed S. Abbady、Abd El-Aal M. Gaber

  DOI：10.1135/cccc19921149

  日期：——

  The biological activity of azocinnoline derivatives especially in the chemotherapy of Trypanosomiasis was already reported. Considering the foregoing and in continuation of our previous work, 3-acetyl-1H-cinnolin-4-one (I) has been well exploited as a coupling component.

  已经报道了偶氮菁衍生物在特别是治疗锥虫病的化疗中的生物活性。考虑到前述情况并延续我们之前的工作，3-乙酰基-1H-菜碱-4-酮（I）已被充分利用作为偶联组分。
• Synthesis and Evaluations of GLP-1 Secretion and Anti-Diabetic Effect in KKAy Mice of New Tricyclic Compounds
  作者：Naoki Toyooka、Isao Adachi、Daisuke Minehira、Daisuke Takeda、Shota Miyawaki、Atsushi Kato、Akira Miyazaki、Ryuta Miyatake、Masahito Umezaki、Kyoko Miura、Yoshiro Kitahara、Kenji Sugimoto、Yuji Matsuya

  DOI：10.3987/com-14-s(k)29

  日期：——

  Glucagon-like peptide-1 (GLP-1), which belongs to the family of incretins, plays important role for the regulation of plasma glucose. Accordingly, GLP-1-based therapies for type 2 diabetes have recognized as one of the most interesting target. In this study, we have found the new tricyclic compounds having strong GLP-1 secretion from human intestinal L cells, and anti-diabetic properties in spontaneously obese and diabetic KKAy mice. The most potent compound 5ka was obtained as the unexpected product, and we would like to report the details of the synthesis, structure elucidations, pharmacological activities on secretion of GLP-1, and anti-diabetic effects using diabetic KKAy mice.
• Thermally stable water insoluble azo-azomethine dyes: Synthesis, characterization and solvatochromic properties
  作者：Hamid Khanmohammadi、Khatereh Rezaeian

  DOI：10.1016/j.saa.2012.07.013

  日期：2012.11

  Six new water insoluble azo-azomethine dyes have been synthesized via condensation reaction of alpha,alpha'-bis(o-aminophenylthio)-1,2-xylene with substituted azo-coupled salicylaldehyde. The condensation reaction provides the expected bis-iminated azo-azomethine dyes in good yields, ranging from 59% to 90%. The dyes have been characterized by IR. UV-Vis and H-1 NMR spectroscopic methods as well as elemental analysis. The thermal behavior of the prepared dyes has been determined using thermogravimetry technique. Furthermore, the effect of various organic solvents with different polarities on the UV-Vis spectra of the dyes has been also studied. (C) 2012 Elsevier B.V. All rights reserved.
• Debi, Journal of the Indian Chemical Society, 1989, vol. 66, # 7, p. 489 - 492
  作者：Debi

  DOI：——

  日期：——