pyridine; compound with phosgene | 93953-03-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: pyridine; compound with phosgene
• 英文别名: Pyridin; Verbindung mit Phosgen；Carbonyl dichloride;pyridine
• CAS: 93953-03-8；103490-59-1
• 化学式: CCl₂O*2C₅H₅N
• 分子量: 257.119
• InChiKey: CCYWVXXWKRBHBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.67
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  pyridine; compound with phosgene 、 苯甲醛 生成 二氯甲基苯
  参考文献：
  名称：

  Chem. Fabr. v. Heyden, Chemisches Zentralblatt, 1901, vol. 72, # I, p. 429

  摘要：

  DOI：
• 作为产物：
  描述：

  吡啶 、 三光气 在 乙醚 作用下， 生成 pyridine; compound with phosgene
  参考文献：
  名称：

  Chem. Fabr. v. Heyden, Chemisches Zentralblatt, 1900, vol. 71, # II, p. 460

  摘要：

  DOI：

文献信息

• Bicyclic triazolone derivatives and a herbicides containing the same
  申请人：——

  公开号：US20040063580A1

  公开（公告）日：2004-04-01

  The present invention provides a bicyclic triazolone derivative represented by the formula: J-Ar  (I) [wherein, J is 1 2 3 ], which has excellent selective weeding activity and weed killer containing the said bicyclic triazolone derivative.

  本发明提供了一种由公式J-Ar表示的双环三唑酮衍生物(I)，其中J为123，具有优异的选择性除草活性，以及含有所述双环三唑酮衍生物的除草剂。
• Piperidine derivatives, their preparation and pharmaceutical compositions containing them
  申请人：af Ekenstam, Bo

  公开号：EP0024382A1

  公开（公告）日：1981-03-04

  A compound of formula in which m and n are a pair of integers such that m = 0 or 1 and n=3-m or m=0, 1 or 2 and n=4-m, R is straight or branched C2 to C4 alkyl having a terminal hydroxy group, R1 is methyl or methoxy, R2 is methyl or ethyl and R3 is hydrogen or methyl; or a pharmaceutically acceptable salt thereof is provided, as well as compositions containing these compounds and processes for preparing them. The compounds can be used to produce topical and local anaesthetic effects in mammals and are also useful as heart anti-arrhythmic agents.

  式的化合物 其中 m 和 n 是一对整数，如 m=0 或 1 和 n=3-m 或 m=0、1 或 2 和 n=4-m、 R 是具有末端羟基的直链或支链 C2 至 C4 烷基、 R1 是甲基或甲氧基 R2 是甲基或乙基 R3 是氢或甲基； 或其药学上可接受的盐，以及含有这些化合物的组合物和制备工艺。这些化合物可用于对哺乳动物产生局部麻醉作用，也可用作抗心律失常的药物。
• Preparation of 2-chloropropionic acid esters
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0163435A2

  公开（公告）日：1985-12-04

  Racemic and optically active alkyl 2-chloropropionates are prepared by reacting the corresponding alkyl lactates with phosgene and decomposing the chloroformates so obtained in the presence of a tertiary base, preferably pyridine. Conveniently, reaction is carried out in a solvent, eg. dichloromethane. The process is particularly useful for preparing optically active alkyl 2-propionates of high purity in which case the chloroformate intermediates, certain of which are novel, are decomposed at a temperature below 60°C, preferably in the range of 20 to 40'C.

  外消旋光学活性 2-氯丙酸烷基酯的制备方法是：将相应的乳酸烷基酯与光气反应， 然后在三级碱（最好是吡啶）存在下分解所得到的氯甲酸酯。反应宜在溶剂（如二氯甲烷）中进行。该工艺特别适用于制备高纯度的光学活性 2-丙酸烷基酯，在这种情况下，氯甲酸 酯中间体（其中某些是新型的）的分解温度低于 60°C，最好在 20 至 40'C 之间。
• Process for producing 2-oxazolidinones
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0244810A1

  公开（公告）日：1987-11-11

  An improved process for producing a 2-oxazolidinone of the formula wherein R represents hydrogen atom or a lower alkyl group and R1 and R2 are the same as or different and each represent hydrogen atom or a lower alkyl group, by reacting an amino-alcohol of the formula wherein R, R1 and R2 are each as defined above, and/or its hydrochloride, with phosgene is provided, which process is characterized by carrying out the reaction substantially in the presence of water and a dehydrochlorinating agent, preferably while keeping the pH of the reaction liquid within a range of 3.0 to 10.0 with the dehydrochlorinating agent in water solvent.

  本发明提供了一种通过使式中R、R1和R2均如上定义的氨基醇和/或其盐酸盐与光气反应生产式中R代表氢原子或低级烷基，R1和R2相同或不同且各自代表氢原子或低级烷基的2-噁唑烷酮的改进工艺，该工艺的特点是基本上在水和脱氯剂存在下进行反应，最好是将反应液的pH值保持在3.0至10.0的范围内，脱氯剂在水溶剂中。
• Tetrahydropyridine oximes, a process for their preparation and use thereof as cholinergic agents
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0291673A1

  公开（公告）日：1988-11-23

  Certain N-substituted 1-(1,2,3,6-tetrahydro-­-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetra­hydro-4-pyridinyl)oximes are useful as analgesic agents or agents for the treatment or amelioration of the symptoms of cerebral insufficiency characterized by decreased central acetylcholine production or release.

  某些 N-取代的 1-(1,2,3,6-四氢-3-吡啶基)肟和 N-取代的 1-(1,2,3,6-四氢-4-吡啶基)肟可用作镇痛剂或治疗或改善以中枢乙酰胆碱产生或释放减少为特征的脑功能不全症状的药物。