5-hydroxy-benzo[a]fluoren-11-one | 60599-30-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 5-hydroxy-benzo[a]fluoren-11-one
• 英文别名: 5-Hydroxy-benzo[a]fluoren-11-on；3-Oxy-1.2-benzo-fluorenon；Oxy-chrysofluorenon；5-Hydroxybenzo[a]fluoren-11-one
• CAS: 60599-30-6
• 化学式: C₁₇H₁₀O₂
• 分子量: 246.265
• InChiKey: FEPSYVTXEIWYEC-UHFFFAOYSA-N

物化性质

• 熔点：
  307-308 °C
• 沸点：
  474.8±14.0 °C(Predicted)
• 密度：
  1.388±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-hydroxy-benzo[a]fluoren-11-one 在 氢碘酸 、 溶剂黄146 、 锌 作用下， 生成 5-hydroxy-11H-benzo[a]fluorene
  参考文献：
  名称：

  153.多环芳烃。第XXIX部分。1：2：5：6-二苯并芴衍生物

  摘要：

  DOI：

  10.1039/jr9440000553
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 三氯化铝 作用下， 生成 5-hydroxy-benzo[a]fluoren-11-one
  参考文献：
  名称：

  Scholl; Seer, Justus Liebigs Annalen der Chemie, 1912, vol. 394, p. 153

  摘要：

  DOI：

文献信息

• Process for preparation of spirofluorenols
  申请人：Shiigi Hirohumi

  公开号：US20060025636A1

  公开（公告）日：2006-02-02

  A spirofluorenol such as 3′,9′-dimethoxy-5′-hydroxyspiro[(1H-cyclopent[d,e,f]phenanthrene)-1,7′-benzo [c] fluorene] is produced by protecting a hydroxyl group bonded to a particular fluorenone compound such as 3,9-dimethoxy-5-hydroxybenzo[c]fluorene-7-one with “a substituted silyl group in which the sum of carbon atoms of substituents bonded to a silicon atom is 5 to 12”, such as a t-butyldimethylsilyl group, then, reacting the fluorenone compound with a particular organometal compound such as 1-lithiophenanthrene so as to be transformed into a spiro form and, then, removing the protection therefrom. This method makes it possible to efficiently produce the spirofluorenol which is useful as a starting material for producing photochromic compounds.

  通过保护与特定芴酮化合物（如3,9-二甲氧基-5-羟基苯并[c]芴-7-酮）相连的羟基，使用“取代硅基团，其中硅原子上的取代基的碳原子总数为5至12”，例如t-丁基二甲基硅基团，制备出螺旋芴醇，例如3′，9′-二甲氧基-5′-羟基螺旋[(1H-环戊[d，e，f]菲-1,7′-苯并[c]芴)]。然后，将芴酮化合物与特定的有机金属化合物（如1-锂菲）反应，使其转化为螺旋形式，然后去除保护。该方法可以有效地生产螺旋芴醇，该物质可用作生产光致变色化合物的起始材料。
• A method for preventing deposition of polymer scale and a coating agent therefor
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0126991A1

  公开（公告）日：1984-12-05

  The invention provides a method for preventing deposition of polymer scale on the reactor walls in the polymerization of an ethylenically unsaturated monomer, in particular, by emulsion polymerization. The method comprises coating the reactor walls with a coating composition containing, as the essential components, (A) an organic compound having at least 5 conjugated π bonds in a molecule, (B) a chelating agent and (C) a metal compound capable of producing metal ions having a coordination number of at leas 2 which presumably forms a metallic chelate compound with the chelating agent contributing to the formation of a strongly adsorbed layer on the reactor walls. The coating composition may be further admixed with a silicic acid compound such as a colloidal silica.

  本发明提供了一种在乙烯基不饱和单体聚合，特别是乳液聚合过程中防止聚合物垢沉积在反应器壁上的方法。该方法包括在反应器壁上涂上涂层组合物，涂层组合物的主要成分包括：(A) 分子中至少有 5 个共轭 π 键的有机化合物；(B) 螯合剂；(C) 能够产生配位数至少为 2 的金属离子的金属化合物，该金属离子可与螯合剂形成金属螯合物，从而在反应器壁上形成强吸附层。涂层组合物还可进一步掺入硅酸化合物，如胶体二氧化硅。
• PROCESS FOR PREPARATION OF SPIROFLUORENOLS
  申请人：Tokuyama Corporation

  公开号：EP1547993A1

  公开（公告）日：2005-06-29

  A spirofluorenol such as 3',9'-dimethoxy-5'-hydroxyspiro[(1H-cyclopent[d,e,f]phenanthrene)-1,7'-benzo[c]fluorene] is produced by protecting a hydroxyl group bonded to a particular fluorenone compound such as 3,9-dimethoxy-5-hydroxybenzo[c]fluorene-7-one with "a substituted silyl group in which the sum of carbon atoms of substituents bonded to a silicon atom is 5 to 12", such as a t-butyldimethylsilyl group, then, reacting the fluorenone compound with a particular organometal compound such as 1-lithiophenanthrene so as to be transformed into a spiro form and, then, removing the protection therefrom. This method makes it possible to efficiently produce the spirofluorenol which is useful as a starting material for producing photochromic compounds.

  一种螺芴醇，如 3',9'-二甲氧基-5'-羟基螺[(1H-环戊并[d,e,f]菲)-1,7'-苯并[c]芴]，是通过保护与特定芴酮化合物（如 3、9-二甲氧基-5-羟基苯并[c]芴-7-酮 "中的取代硅基，其中与硅原子结合的取代基的碳原子数总和为 5 至 12"、例如 t-丁基二甲基硅基，然后将芴酮化合物与特定的有机金属化合物（例如 1-硫代菲）反应，使其转变为螺环形式，然后去除其中的保护层。这种方法可以有效地生产出螺芴醇，它可以作为生产光致变色化合物的起始原料。
• Divergent Access to 1-Naphthols and Isocoumarins via Rh(III)-Catalyzed C–H Activation Assisted by Phosphonium Ylide
  作者：Yunyun Li、Qiang Wang、Xifa Yang、Fang Xie、Xingwei Li

  DOI：10.1021/acs.orglett.7b01365

  日期：2017.7.7

  Rh-catalyzed C-H activation of phenacyl phosphoniums in coupling with alpha-diazocarbonyl compounds has been realized with the assistance of a mutifunctional phosphonium ylidic directing group, providing expedient accesses to 1-naphthols and isocoumarins. Switchable synthesis of 1-naphthols and isocoumarins was realized by substrate control, where these transformations were enabled by initial C-H activation and subsequent intramolecular Wittig reaction or nucleophilic C-O formation.
• Scholl; Seer, Justus Liebigs Annalen der Chemie, 1912, vol. 394, p. 153
  作者：Scholl、Seer

  DOI：——

  日期：——