N-Methyl-(phenoxy)phosphonamidic acid | 23505-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Methyl-(phenoxy)phosphonamidic acid
• 英文别名: N-methyl-phenoxyphosphonamidic acid
• CAS: 23505-14-8
• 化学式: C₇H₁₀NO₃P
• 分子量: 187.135
• InChiKey: SIZSMZMOBOCREQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙醇 、 diphenyl methylphosphoramidate 以 水 为溶剂， 生成 diethyl N-methylphosphoramidate 、 Methyl-phosphoramidic acid monoethyl ester 、 N-Methyl-(phenoxy)phosphonamidic acid
  参考文献：
  名称：

  Kasparek, Frantisek; Mollin, Jiri, Collection of Czechoslovak Chemical Communications, 1980, vol. 45, # 2, p. 386 - 396

  摘要：

  DOI：

文献信息

• NONCARDIOTOXIC PHARMACEUTICAL COMPOUNDS
  申请人：Barbeau, Donald L.

  公开号：EP1778252A2

  公开（公告）日：2007-05-02
• [EN] NONCARDIOTOXIC PHARMACEUTICAL COMPOUNDS<br/>[FR] COMPOSES PHARMACEUTIQUES NON CARDIOTOXIQUES
  申请人：BARBEAU DONALD L

  公开号：WO2006020573A2

  公开（公告）日：2006-02-23

  The present invention relates to novel noncardiotoxic compounds and pharmaceutical compositions useful in the treatment of a variety of disorders including the treatment of depression, allergies, psychoses, cancer and gastrointestinal disorders. In particular, the present invention describes pharmaceutical compositions that mitigate life-threatening arrhythmias such as torsade de pointes. Torsade de pointes is a particular cardiac problem associated with many therapeutic agents and has been implicated as a possible cause of sudden death, particularly in those individuals with a past history of disturbances of cardiac rhythm, myocardial infarction, congenital repolarization abnormalities and cardiac risk factors such as hyperlipidemia and age. This arrhythmia is a variant of paroxysmal ventricular tachycardia associated with a prolonged QTc interval or prominent U waves on the ECG. Torsade de pointes is potentially lethal because it can progress to ventricular fibrillation, life-threatening arrhythmias or precipitate sudden death.
• Kasparek, Frantisek; Mollin, Jiri, Collection of Czechoslovak Chemical Communications, 1980, vol. 45, # 2, p. 386 - 396
  作者：Kasparek, Frantisek、Mollin, Jiri

  DOI：——

  日期：——