4-(Dimethylamino)-1-(naphthalen-1-YL)butan-1-one | 77252-96-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(Dimethylamino)-1-(naphthalen-1-YL)butan-1-one
• 英文别名: 4-(dimethylamino)-1-naphthalen-1-ylbutan-1-one
• CAS: 77252-96-1
• 化学式: C₁₆H₁₉NO
• 分子量: 241.333
• InChiKey: HYIPNOUQNBFDER-UHFFFAOYSA-N

物化性质

• 沸点：
  147-150 °C(Press: 0.4 Torr)
• 密度：
  1.056±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(Dimethylamino)-1-(naphthalen-1-YL)butan-1-one 、 6-溴-2-甲氧基喹啉 在 2,2,6,6-四甲基哌啶 、 正丁基锂 、 水 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 5.5h， 以20%的产率得到1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-1-naphthalen-1-ylbutan-1-ol
  参考文献：
  名称：

  WO2008/68270

  摘要：

  公开号：
• 作为产物：
  描述：

  5-二甲基氨基-2-萘-1-基戊腈 在 sodium hydroxide 、 苄基三乙基氯化铵 、 氧气 作用下， 反应 5.0h， 以71%的产率得到4-(Dimethylamino)-1-(naphthalen-1-YL)butan-1-one
  参考文献：
  名称：

  Phase-Transfer Catalyzed Oxidative Decyanation of α-Secondary Nitriles; A Convenient Synthesis of Aromatic Ketones

  摘要：

  DOI：

  10.1055/s-1980-29301

文献信息

• WO2007/434
  申请人：——

  公开号：——

  公开（公告）日：——
• DONETTI A.; BONIARDI O.; EZHAYA A., SYNTHESIS, 1980, NO 12, 1009-1011
  作者：DONETTI A.、 BONIARDI O.、 EZHAYA A.

  DOI：——

  日期：——
• Quinoline Derivatives as Antibacterial Agents
  申请人：Andries Koenraad Jozef Lodewijk Marcel

  公开号：US20100197727A1

  公开（公告）日：2010-08-05

  Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a N-oxide, a tautomeric form or a stereochemically isomeric form thereof wherein A − is a counter ion; R 1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1 to 4; R 2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or wherein Y is CH 2 , O, S, NH or N-alkyl; R 3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 0 to 4; R 4 and R 5 each independently are hydrogen, alkyl or benzyl; or R 4 and R 5 may be taken together including the N to which they are attached; R 6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R 6 radicals may be taken together to form —CH═CH—CH═CH—; r is 1 to 5; R 7 is hydrogen, alkyl, Ar or Het; R 8 is hydrogen or alkyl; R 9 is oxo; or R 8 and R 9 taken together form —CH═CH—N═; R 10 is alkyl, alkylcarbonyl, Ar, Ar-alkyl, Ar-carbonyl, Het 1 -alkyl or Het 1 -carbonyl.
• ANTIBACTERIAL QUINOLINE DERIVATIVES
  申请人：Guillemont Jérôme Emile Georges

  公开号：US20110166179A1

  公开（公告）日：2011-07-07

  The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or formula (Ib): including any stereochemically isomeric form thereof, a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvateas thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.
• QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：ANDRIES Koenraad Jozef Lodewijk

  公开号：US20130030016A1

  公开（公告）日：2013-01-31

  Method of treating a bacterial infection other than a Mycobacterial infection, using a compound of formula (Ia) or (Ib) a N-oxide, a tautomeric form or a stereochemically isomeric form thereof; A − is a counter ion; and the substituents R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are as defined.