4-methoxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzaldehyde | 329217-66-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-methoxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzaldehyde
• 英文别名: 3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4-methoxy-benzaldehyde；4-methoxy-3-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)benzaldehyde
• CAS: 329217-66-5
• 化学式: C₂₃H₂₈O₂
• 分子量: 336.474
• InChiKey: LAJMQRHDYIMLJE-UHFFFAOYSA-N

物化性质

• 沸点：
  436.8±45.0 °C(Predicted)
• 密度：
  1.018±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methoxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzaldehyde 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以84%的产率得到4-hydroxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzaldehyde
  参考文献：
  名称：

  Heterocyclic derivatives for the treatment of diabetes and other diseases

  摘要：

  本发明涉及某些Formula (I)的取代杂环，这些取代杂环在治疗与脂质和碳水化合物代谢相关的疾病方面很有用，如2型糖尿病、脂肪细胞分化、不受控制的增殖，如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或一般癌症；以及炎症，如骨关节炎、类风湿关节炎、克罗恩病或炎症性肠病。

  公开号：

  US06515003B1
• 作为产物：
  描述：

  3-溴-4-甲氧基苯甲醛 、 3,5,5,8,8-五甲基-5,6,7,8-四氢萘-2-硼酸 在 三苯基膦钯 potassium carbonate 作用下， 以 乙二醇二甲醚 、 水 为溶剂， 以90%的产率得到4-methoxy-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzaldehyde
  参考文献：
  名称：

  Heterocyclic derivatives for the treatment of diabetes and other diseases

  摘要：

  本发明涉及某些Formula (I)的取代杂环，这些取代杂环在治疗与脂质和碳水化合物代谢相关的疾病方面很有用，如2型糖尿病、脂肪细胞分化、不受控制的增殖，如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或一般癌症；以及炎症，如骨关节炎、类风湿关节炎、克罗恩病或炎症性肠病。

  公开号：

  US06515003B1

文献信息

• Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia
  申请人：——

  公开号：US20030083357A1

  公开（公告）日：2003-05-01

  The present invention relates to compounds of Formula (I) which may be useful in the treatment of diseases, such as, metabolic disorders, dyslipidemia and/or hyperchloesterolemia: 1

  本发明涉及Formula (I)的化合物，可能在治疗疾病，如代谢紊乱、血脂异常和/或高胆固醇血症方面有用：
• N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders; cancer, and other diseases
  申请人：——

  公开号：US20030144329A1

  公开（公告）日：2003-07-31

  The present invention relates to certain compounds of Formula (I) which can be useful in the treatment of diseases, such as, cancer, metabolic disorders, Type 2 Diabetes, dyslipidemia and/or hyperchloesterolemia: 1

  本发明涉及某些化合物的公式（I），这些化合物可用于治疗疾病，如癌症、代谢紊乱、2型糖尿病、血脂异常和/或高胆固醇血症。
• Substituted heterocycles for the treatment of diabetes and other diseases
  申请人：Pfahl Magnus

  公开号：US20060004059A1

  公开（公告）日：2006-01-05

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及公式（I）的某些取代杂环，其在治疗与脂质和碳水化合物代谢有关的疾病中有用，例如2型糖尿病，脂肪细胞分化，不受控制的增殖（如淋巴瘤，霍奇金病，白血病，乳腺癌，前列腺癌或癌症总体）和炎症（如骨关节炎，类风湿性关节炎，克罗恩病或炎性肠病）。
• Imidazolidinedione derivatives for the treatment of diabetes and other diseases
  申请人：Pfahl Magnus

  公开号：US20050070581A1

  公开（公告）日：2005-03-31

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及某些式(I)的取代杂环，其在治疗与脂质和碳水化合物代谢有关的疾病方面是有用的，例如2型糖尿病、脂肪细胞分化、不受控制的增殖，如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或普遍的癌症；以及炎症，例如骨关节炎、类风湿性关节炎、克罗恩病或炎性肠病。
• Thiazolidinedione derivatives for the treatment of diabetes and other diseases
  申请人：Maxia Pharmaceuticals, Inc.

  公开号：US20030153606A1

  公开（公告）日：2003-08-14

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease. 1

  本发明涉及公式(I)的某些取代杂环，其在治疗与脂质和碳水化合物代谢相关的疾病方面有用，例如2型糖尿病、脂肪细胞分化、不受控制的增殖，例如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或一般的癌症；以及炎症，例如骨关节炎、风湿性关节炎、克隆氏病或炎性肠病。