3-hydroxy-4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)benzaldehyde | 329204-11-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-hydroxy-4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)benzaldehyde
• 英文别名: 3-Hydroxy-4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl) benzaldehyde；3-hydroxy-4-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)benzaldehyde
• CAS: 329204-11-7
• 化学式: C₂₂H₂₆O₂
• 分子量: 322.447
• InChiKey: ICFPWIPZCFZKGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-3-methoxy benzaldehyde 在 sodium acetate 、 三溴化硼 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 以62%的产率得到3-hydroxy-4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)benzaldehyde
  参考文献：
  名称：

  Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia

  摘要：

  本发明涉及Formula (I)的化合物，可能在治疗疾病，如代谢紊乱、血脂异常和/或高胆固醇血症方面有用：

  公开号：

  US20030083357A1

文献信息

• BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION
  申请人：Maxia Pharmaceuticals, Inc.

  公开号：EP1214305A1

  公开（公告）日：2002-06-19
• OXIME DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA AND HYPERCHOLESTEREMIA
  申请人：Incyte San Diego Incorporated

  公开号：EP1421061A1

  公开（公告）日：2004-05-26
• EP1421061A4
  申请人：——

  公开号：EP1421061A4

  公开（公告）日：2004-12-22
• [EN] BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION<br/>[FR] BENZYLIDENE-THIAZOLIDINEDIONES ET ANALOGUES ET LEUR UTILISATION POUR LE TRAITEMENT DE L'INFLAMMATION
  申请人：MAXIA PHARMACEUTICALS INC

  公开号：WO2001016123A1

  公开（公告）日：2001-03-08

  The present invention relates to certain substituted heterocycles of Formula (I) which may be useful in the treatment of diseases related to uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.
• [EN] OXIME DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA AND HYPERCHOLESTEREMIA<br/>[FR] DERIVES D'OXIME POUR LE TRAITEMENT DE LA DYSLIPIDEMIE ET DE L'HYPERCHOLESTEROLEMIE
  申请人：MAXIA PHARMACEUTICALS INC

  公开号：WO2003016267A1

  公开（公告）日：2003-02-27

  The present invention relates to compounds of Formula (I) which may be useful in the treatment of diseases, such as, metabolic disorders, dyslipidemia and/or hypercholesteremia: (I).