1-benzhydryl-4-(5-phenyl-2,4-pentadienyl)piperazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzhydryl-4-(5-phenyl-2,4-pentadienyl)piperazine
• 英文别名: 1-benzhydryl-4-[(2E,4E)-5-phenylpenta-2,4-dienyl]piperazine
• 化学式: C₂₈H₃₀N₂
• 分子量: 394.56
• InChiKey: XBDBCIXSZHCCSO-CWUHIXJFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-benzhydryl-4-(5-phenyl-2,4-pentadienoyl)piperazine 、 氢化铝锂 生成 1-benzhydryl-4-(5-phenyl-2,4-pentadienyl)piperazine
  参考文献：
  名称：

  HATTORI, SHIN;TAKAI, MAKOTO;WAKABAYASHI, TOSHIO;SUWABE, YASUSI;MIYSOKA, S+

  摘要：

  DOI：

文献信息

• Diene derivatives and vasodilators containing the same
  申请人：Terumo Kabushiki Kaisha

  公开号：US04792553A1

  公开（公告）日：1988-12-20

  Novel dienyl derivatives are disclosed. As examples of said diene derivative are mentioned 1-benzhydryl-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-benzhydryl-4-(5-(3,4,5-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-(2,4-dimethoxyphenyl)-2,4-pentadienyl)pip erazine, 1-benzhydryl-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl) piperazine and the like. These dienyl derivatives are useful as vasodilators.

  披露了新颖的二烯基衍生物。作为所述二烯衍生物的示例，提到了1-苯甲基-4-(5-苯基-2,4-戊二烯基)哌嗪、1-(4,4'-二氟苯甲基)-4-(5-苯基-2,4-戊二烯基)哌嗪、1-苯甲基-4-(5-(3,4,5-三甲氧基苯基)-2,4-戊二烯基)哌嗪、1-(4,4'-二氟苯甲基)-4-(5-(2,4-二甲氧基苯基)-2,4-戊二烯基)哌嗪、1-苯甲基-4-(5-(2,3,4-三甲氧基苯基)-2,4-戊二烯基)哌嗪、1-(4,4'-二氟苯甲基)-4-(5-(2,3,4-三甲氧基苯基)-2,4-戊二烯基)哌嗪等。这些二烯基衍生物可用作血管扩张剂。
• HATTORI, SHIN;TAKAI, MAKOTO;WAKABAYASHI, TOSHIO;SUWABE, YASUSI;MIYSOKA, S+
  作者：HATTORI, SHIN、TAKAI, MAKOTO、WAKABAYASHI, TOSHIO、SUWABE, YASUSI、MIYSOKA, S+

  DOI：——

  日期：——
• JPS62277370A
  申请人：——

  公开号：JPS62277370A

  公开（公告）日：1987-12-02
• COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES
  申请人：Johansen Lisa M.

  公开号：US20110028564A1

  公开（公告）日：2011-02-03

  The invention features compositions, methods, and kits useful for the treatment of filovirus-mediated diseases, e.g., hemorrhagic fever caused by Ebola virus, in an animal.
• METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER
  申请人：Haggerty Timothy J.

  公开号：US20140335050A1

  公开（公告）日：2014-11-13

  The invention features methods, compositions, and kits for the administration of an HSP90 inhibitor, OBAA, flunarizine, aphidicolin, damnacanthal, dantrolene, or an analog thereof, alone, or in combination with, e.g., a TAA, an antigen-binding scaffold (e.g., an antibody, a soluble T cell receptor, or a chimeric receptor) specific for a TAA, a cell (e.g., a white blood cell that targets a cancer cell), and/or an IFN-β receptor agonist or an IFN-γ receptor agonist, for the treatment of cancer.