N-[3-[[Diethylamino]methyl]-4-hydroxy-5-[1-methylethyl]phenyl]acetamide | 107244-64-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3-[[Diethylamino]methyl]-4-hydroxy-5-[1-methylethyl]phenyl]acetamide
• 英文别名: N-[3-(diethylaminomethyl)-4-hydroxy-5-propan-2-ylphenyl]acetamide
• CAS: 107244-64-4
• 化学式: C₁₆H₂₆N₂O₂
• 分子量: 278.395
• InChiKey: VGMZYNQWHJSJQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[3-[[Diethylamino]methyl]-4-hydroxy-5-[1-methylethyl]phenyl]acetamide 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-(1-methylethyl)phenol Nω oxide
  参考文献：
  名称：

  Antimalarial drugs. 61. Synthesis and antimalarial effects of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N.omega.-oxides

  摘要：

  A series of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N omega-oxides were synthesized by the condensation of 4,7-dichloroquinoline and 4,7-dichloroquinoline N omega-oxide with appropriately substituted 4-amino-2-[(diethylamino)methyl]-6-alkylphenol dihydrochlorides. The latter precursors were prepared in a six-step synthesis starting from available 2-alkylphenols. Several of the title compounds display potent antimalarial activity in mice.

  DOI：

  10.1021/jm00388a027
• 作为产物：
  描述：

  4-氨基-2-异丙基苯酚 以 四氢呋喃 、 甲醇 、 乙醇 为溶剂， 反应 48.5h， 生成 N-[3-[[Diethylamino]methyl]-4-hydroxy-5-[1-methylethyl]phenyl]acetamide
  参考文献：
  名称：

  Antimalarial drugs. 61. Synthesis and antimalarial effects of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N.omega.-oxides

  摘要：

  A series of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N omega-oxides were synthesized by the condensation of 4,7-dichloroquinoline and 4,7-dichloroquinoline N omega-oxide with appropriately substituted 4-amino-2-[(diethylamino)methyl]-6-alkylphenol dihydrochlorides. The latter precursors were prepared in a six-step synthesis starting from available 2-alkylphenols. Several of the title compounds display potent antimalarial activity in mice.

  DOI：

  10.1021/jm00388a027

文献信息

• KESTEN S. J.; JOHNSON J.; WERBEL L. M., J. MED. CHEM., 30,(1987) N 5, 906-911
  作者：KESTEN S. J.、 JOHNSON J.、 WERBEL L. M.

  DOI：——

  日期：——