1,7-萘二磺酸 | 5724-16-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1,7-萘二磺酸
• 英文名称: naphthalene-1,7-disulphonic acid
• 英文别名: naphthalene-1,7-disulfonic acid；naphthalene-1,7-disulfonate；1,7-disulfonaphthalene；1,7-naphthalenedisulfonic acid；Naphthalin-1,7-disulfonsaeure
• CAS: 5724-16-3
• 化学式: C₁₀H₈O₆S₂
• 分子量: 288.302
• InChiKey: HYFMZOAPNQAXHU-UHFFFAOYSA-N

物化性质

• 溶解度：
  甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 、 二氧化硫 、 铜 作用下， 生成 1,7-萘二磺酸
  参考文献：
  名称：

  萘磺化的研究

  摘要：

  1.异构体比率是直接磺化的复杂比率。从萘开始，在130°下，可以并排检测到根据阿姆斯特朗规则的所有可能的二磺酸，包括1,5和2,6酸。

  DOI：

  10.1002/hlca.660280132

文献信息

• [EN] METHODS OF CHEMICAL SYNTHESIS OF SUBSTITUTED 10H-PHENOTHIAZINE-3,7-DIAMINE COMPOUNDS<br/>[FR] PROCÉDÉS DE SYNTHÈSE CHIMIQUE DE COMPOSÉS SUBSTITUÉS DE 10H-PHÉNOTHIAZINE-3,7-DIAMINE
  申请人：WISTA LAB LTD

  公开号：WO2017013174A1

  公开（公告）日：2017-01-26

  The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.

  本发明通常涉及化学合成领域，更具体地涉及包括通过还原胺基烷基化步骤来制备配位替代的10H-苯并噻嗪-3,7-二胺化合物的化学合成方法，其中将配位未替代的Formula（4）的二胺与醛/酮在还原胺基化条件下反应。本发明还涉及这种方法，其中包括额外的后续和/或先前步骤，例如，从Formula（1）的化合物制备Formulae（2）和（3）的化合物，以及从Formulae（5）、（6）、（7）、（8）和（9）的化合物制备Formula（4）的化合物。例如，Formula（1）、Formula（2）和Formula（3）的化合物在蛋白质聚集性疾病的治疗中是有用的，例如阿尔茨海默病。
• Crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for preparing same and pharmaceutical composition containing same
  申请人：Yun Sangmin

  公开号：US20050228012A1

  公开（公告）日：2005-10-13

  A crystalline clopidogrel naphthalenesulfonate or a hydrate thereof, a method for preparing same, and a pharmaceutical composition containing same are provided.

  提供了一种结晶的氯吡格雷萘磺酸盐或其水合物，一种制备方法以及含有该物质的药物组合物。
• [EN] CRYSTALLINE CLOPIDOGREL NAPHTHALENESULFONATE OR HYDRATE THEREOF, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITION CONTAINING SAME<br/>[FR] NAPHTHALENESULFONATE CRISTALLIN DE CLOPIDOGREL OU HYDRATE DE CELUI-CI, PROCEDE PERMETTANT DE LE PREPARER ET COMPOSITION PHARMACEUTIQUE LE CONTENANT
  申请人：HANMI PHARM IND CO LTD

  公开号：WO2005097804A1

  公开（公告）日：2005-10-20

  A crystalline clopidogrel naphthalenesulfonate or a hydrate thereof, a method for preparing same, and a pharmaceutical composition containing same are provided.

  提供一种结晶的氯吡格雷萘磺酸盐或其水合物，以及制备该物质的方法和含有该物质的药物组合物。
• COMPOUND HAVING HEPTAMETHINE STRUCTURE, SENSITIZING DYE AND PHOTOELECTRIC CONVERSION ELEMENT
  申请人：Gifu University

  公开号：EP2684872A1

  公开（公告）日：2014-01-15

  Provided is a compound having a heptamethine structure represented by the following general formula (1) used as a sensitizing dye for a photoelectric conversion device, and a photoelectric conversion device using the compound as a sensitizing dye, which may solve the problems of the related art. In the general formula (1), R1 and R2 each represent a hydrogen atom, an alkyl group or an aryl group; R3 to R6 each represent an alkyl group having from 1 to 18 carbon atoms; X represents a halogen atom; Y represents a monovalent anion; Z represents an alkyl group, an alkoxy group or an aryl group when R3 to R6 each have from 1 to 5 carbon atoms, or a hydrogen atom, an alkyl group, an alkoxy group or an aryl group when R3 to R6 each have from 6 to 18 carbon atoms; and m and n each represent an integer of from 1 to 12.

  提供的是一种具有七甲基结构的化合物，其通式如下（1），用作光电转换装置的敏化染料，以及使用该化合物作为敏化染料的光电转换装置，可以解决相关技术中的问题。在通式（1）中，R1和R2分别代表氢原子、烷基或芳基；R3至R6每个代表具有1到18个碳原子的烷基；X代表卤素原子；Y代表一价阴离子；当R3至R6每个具有1到5个碳原子时，Z代表烷基、烷氧基或芳基；当R3至R6每个具有6到18个碳原子时，Z代表氢原子、烷基、烷氧基或芳基；m和n各代表1到12的整数。
• Electroconductive Coating Composition And Process For Production Of Electroconductive Coating Film
  申请人：Otaka Takeshi

  公开号：US20120119154A1

  公开（公告）日：2012-05-17

  Provided is an electroconductive coating composition which is soluble in solvent and exhibits excellent proccessability, and the electric conductivity of which rarely lowers even under high temperature conditions. An electroconductive coating composition (A) characterized by containing both a substituted polythiophene (P) and a dopant (D), said substituted polythiophene (P) being a polythiophene in which at least some of the thiophene repeating unit are each a thiophene repeating unit (α) which is substituted at the 3-position and/or the 4-position of a thiophene ring by (a) a polyether group that comprises 1 to 9 C2-4 oxyalkylene group repeating units and that has a C1-15 alkoxy group at one terminal, (b) an alkoxy group, (c) an alkoxyalkyl group, or (d) an alkyl group that is substituted or unsubstituted by the polyether group (a).

  提供的是一种可溶于溶剂且具有良好加工性的电导涂料组合物，其电导性即使在高温条件下也很少降低。一种电导涂料组合物（A），其特征在于含有替代聚噻吩（P）和掺杂剂（D），所述替代聚噻吩（P）是一种聚噻吩，其中至少一些噻吩重复单元是在噻吩环的3-位置和/或4-位置上被（a）包括1至9个C2-4氧烷基重复单元且在一端具有C1-15烷氧基的聚醚基团、（b）烷氧基、（c）烷氧基烷基团或（d）被聚醚基团（a）取代或未取代的烷基团。