3-methyl-1,5-diphenylpentan-3-ol | 125153-07-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methyl-1,5-diphenylpentan-3-ol
• 英文别名: 3-Methyl-1,5-diphenyl-3-pentanol
• CAS: 125153-07-3
• 化学式: C₁₈H₂₂O
• 分子量: 254.372
• InChiKey: UUTQEHONMQDOTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-methyl-1,5-diphenylpentan-3-ol 在 三氯化铁 作用下， 生成 1-Methyl-1-(2-phenylaethyl)-indan
  参考文献：
  名称：

  Thiabenzene. II. Rearrangement of 1-Alkyl-2,4,6-triphenylthiabenzenes to 2- and 4-Alkyltriphenylthiopyrans

  摘要：

  DOI：

  10.1021/ja00870a018
• 作为产物：
  描述：

  3-甲基-1,5-二苯基戊-1,4-二炔-3-醇 在 钯 作用下， 生成 3-methyl-1,5-diphenylpentan-3-ol
  参考文献：
  名称：

  Salkind, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920, vol. 50, p. 25

  摘要：

  DOI：

文献信息

• Catalytic Generation and Use of Ketyl Radical from Unactivated Aliphatic Carbonyl Compounds
  作者：Hyowon Seo、Timothy F. Jamison

  DOI：10.1021/acs.orglett.9b04235

  日期：2019.12.20

  radical from unactivated aliphatic carbonyl compounds is an important strategy in organic synthesis. Herein, catalytic generation and use of a ketyl radical for the reductive coupling of aliphatic carbonyl compounds and styrenes by organic photoredox catalysis is described. The method is applicable to both aliphatic ketones and aldehydes to afford the corresponding tertiary and secondary alcohols in continuous

  由未活化的脂族羰基化合物生成酮基是有机合成中的重要策略。在此，描述了通过有机光氧化还原催化的酮基的催化生成和用于脂族羰基化合物和苯乙烯的还原偶联。该方法适用于脂肪族酮和醛，以连续流动和间歇的方式提供相应的叔醇和仲醇。初步的机理研究表明，酮基自由基中间体的催化形成。
• Tripyrrolidinophosphoric Acid Triamide as an Activator in Samarium Diiodide Reductions
  作者：Chriss E. McDonald、Jeremy D. Ramsey、David G. Sampsell、Julie A. Butler、Michael R. Cecchini

  DOI：10.1021/ol102040s

  日期：2010.11.19

  The electrochemical and spectrophotometric characterization of the complex formed from samarium diiodide and 4 equiv of tripyrrolidinophosphoric acid triamide (TPPA) is presented. Kinetic studies indicate that the SmI2/TPPA complex possesses reactivity greater than the complex formed between samarium diiodide and 4 equiv of HMPA. Examples of the use of SmI2/TPPA in synthesis are presented.

  提出了由二碘化sa和4当量的三吡咯烷基磷酸三酰胺（TPPA）形成的配合物的电化学和分光光度法表征。动力学研究表明，SmI 2 / TPPA复合物的反应活性大于二碘化sa与HMPA 4当量之间形成的复合物。给出了在合成中使用SmI 2 / TPPA的例子。
• Characterization of the complex formed between samarium diiodide and the dehydro dimer of HMPA (diHMPA)
  作者：Chriss E. McDonald、Jeremy D. Ramsey、James A. Grant、Kelly A. Howerter

  DOI：10.1016/j.tetlet.2009.06.139

  日期：2009.9

  A new ligand that facilitates samarium diiodide-mediated reductions has been developed. Addition of a solution of samarium diiodide to the dehydro dimer of hexamethylphosphoramide results in a purple complex which is an excellent reductant for a variety of organic functionalities. The complex was characterized by the kinetics of reduction of 1-bromodecane, visible spectroscopy, and cyclic voltammetry

  已经开发出促进二碘化sa介导的还原的新配体。将二碘化sa溶液加到六甲基磷酰胺的脱氢二聚体上，得到紫色络合物，它是多种有机功能的极佳还原剂。该复合物的特征在于1-溴代甘蔗还原的动力学，可见光谱和循环伏安法。
• Sonochemical, Aerobic Conversion of Alkyl Halides into Alcohols Promoted by Trialkyltin Halide/NaBH₃CN Catalytic System
  作者：Masaya Sawamura、Yasuhide Kawaguchi、Kenichi Sato、Eiichi Nakamura

  DOI：10.1246/cl.1997.705

  日期：1997.8

  Under sonochemical conditions, various alkyl halides were converted into the corresponding alcohols in high yields through an aerobic radical reaction promoted by trialkyltin halide/NaBH3CN catalytic system.

  在声化学条件下，通过三烷基锡卤化物/NaBH3CN催化体系促进的有氧自由基反应，各种烷基卤化物以高产率转化为相应的醇。
• An efficient intermolecular carbon-carbon bond formation via SmI2-promoted anion radical alkylation
  作者：Osamu Ujikawa、Junji Inanaga、Masaru Yamaguchi

  DOI：10.1016/s0040-4039(00)99138-x

  日期：1989.1

  Anion radicals generated from the corresponding ketones with the efficient one electron transfer system, SmI2-THF-HMPA, attacked a variety of activated olefins at room temperature affording the corresponding addition products in good to excellent yields, some of which are hardly accessible by the conventional nucleophilic alkylation of ketones.

  在室温下，由相应的酮与有效的一个电子转移系统SmI 2 -THF-HMPA生成的阴离子自由基会攻击各种活化的烯烃，从而提供相应的加成产物，收率良好至极佳，其中一些几乎不能被烯烃获得。酮的常规亲核烷基化。