N'-Isopropyl-morpholine-N-carboxamide | 50708-02-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N'-Isopropyl-morpholine-N-carboxamide
• 英文别名: morpholine-4-carboxylic acid isopropylamide；N'-isopropylmorpholine-N-carboxamide；N-(N'-Isopropylcarbamoyl)-morpholin；N-(Isopropylcarbamoyl)-morpholin；4-Morpholinecarboxamide, N-(1-methylethyl)-；N-propan-2-ylmorpholine-4-carboxamide
• CAS: 50708-02-6
• 化学式: C₈H₁₆N₂O₂
• mdl: MFCD02859868
• 分子量: 172.227
• InChiKey: VGEHUCHOIFQYFR-UHFFFAOYSA-N

物化性质

• 沸点：
  352.2±31.0 °C(Predicted)
• 密度：
  1.062±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吗啉 、 异氰酸异丙酯 以 二氯甲烷 为溶剂， 反应 2.0h， 以98%的产率得到N'-Isopropyl-morpholine-N-carboxamide
  参考文献：
  名称：

  ROMPGEL Scavengers:  A High-Loading Supported Anhydride for Sequestering Amines and Hydrazines

  摘要：

  [GRAPHICS]A versatile method for sequestering excess amines and hydrazines is reported using a high loading ROMPGEL anhydride polymer.

  DOI：

  10.1021/ol006191s

文献信息

• [EN] AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON<br/>[FR] COMPOSÉS D'AMINO-PYRIMIDINE EN TANT QU'INHIBITEURS DE TBKL ET OU D'IKK EPSILON
  申请人：MYREXIS INC

  公开号：WO2011046970A1

  公开（公告）日：2011-04-21

  The invention relates to certain amino-pyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).

  这项发明涉及抑制TBK1和/或IKK epsilon的某些氨基嘧啶化合物，因此可能在治疗炎症、癌症、感染性休克和/或原发性开角青光眼（POAG）中找到应用。
• CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS
  申请人：Prelude Therapeutics Incorporated

  公开号：US20210070761A1

  公开（公告）日：2021-03-11

  The disclosure is directed to, in part, to CDK inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.

  该披露部分涉及CDK抑制剂，包含相同物质的药物组合物，以及它们的使用和制备方法。
• NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Gopalan Balasubramanian

  公开号：US20090182143A1

  公开（公告）日：2009-07-16

  The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The present invention more particularly relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the Formula (1), their analogs, tautomers, enantiomers, diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxide, pharmaceutically acceptable solvates and the pharmaceutical compositions containing them.

  本发明涉及新型杂环化合物、它们的类似物、互变异构体、位置异构体、立体异构体、对映异构体、顺反异构体、多晶型、药学上可接受的盐、适当的N-氧化物、药学上可接受的溶剂和含有它们的制药组合物。本发明更特别地涉及式（1）的新型磷酸二酯酶4（PDE4）抑制剂、它们的类似物、互变异构体、对映异构体、顺反异构体、位置异构体、立体异构体、多晶型、药学上可接受的盐、适当的N-氧化物、药学上可接受的溶剂和含有它们的制药组合物。
• N-Aminosulfenyl carbamate compounds, compositions and use
  申请人：Union Carbide Corporation

  公开号：US04315928A1

  公开（公告）日：1982-02-16

  A novel class of N-aminosulfenyl carbamate compositions have outstanding insecticidal and miticidal properties coupled with very low toxicity to mammals and important economic crops.

  一种新型的N-氨基硫酰基氨基甲酸酯组合物具有优异的杀虫和杀螨性能，同时对哺乳动物和重要经济作物的毒性非常低。
• AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1
  申请人：HOLCOMB Ryan C.

  公开号：US20120238540A1

  公开（公告）日：2012-09-20

  The invention relates to certain amino-pyrimidine compounds that inhibit IKK epsilon and/or TBK1, methods of making such compounds, pharmaceutical compositions comprising such compounds, and the use of these compounds in treating a variety of diseases and disorders.

  本发明涉及一些氨基嘧啶化合物，可抑制IKK epsilon和/或TBK1，制备这种化合物的方法，包含这种化合物的药物组合物，以及在治疗各种疾病和疾病失调中使用这些化合物的方法。