N-(4-甲氧基苯胺基)甲酰胺 | 35020-01-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-甲氧基苯胺基)甲酰胺
• 英文名称: 1-(p-Methoxyphenyl)-2-formylhydrazine
• 英文别名: N²-Formyl-p-methoxy-phenylhydrazin；N'-Formyl-N-p-methoxyphenylhydrazin；Hydrazinecarboxaldehyde, 2-(4-methoxyphenyl)-；N-(4-methoxyanilino)formamide
• CAS: 35020-01-0
• 化学式: C₈H₁₀N₂O₂
• 分子量: 166.18
• InChiKey: MQHVSBTWLBWOLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(4-甲氧基苯胺基)甲酰胺 在 盐酸 作用下， 以 氯仿 、 溶剂黄146 为溶剂， 生成 2-[1-[(4-bromophenyl)carbamoyl]-5-methoxy-2-methylindol-3-yl]acetic acid
  参考文献：
  名称：

  从氨基脲制备吲哚的氨基甲酰基衍生物和1,2,4-三唑-3-酮的衍生物

  摘要：

  描述了一种简单的一步法制备标题化合物。氨基脲 2 在 HCl 存在下很容易与乙酰丙酸反应生成 4，而在碱性介质中它们环化生成三唑衍生物 3。

  DOI：

  10.1002/ardp.19823150116
• 作为产物：
  描述：

  α-p-Chlor-benzoyl-β-acyl-p-methoxy-phenylhydrazin 、 sodium hydroxide 生成 N-(4-甲氧基苯胺基)甲酰胺
  参考文献：
  名称：

  ZIKOLOVA, T., TR. N.-I. XIMIKOFARM. IN-T, NRB, 1983, 13, 213-218

  摘要：

  DOI：

文献信息

• NPY Y5 ANTAGONIST
  申请人：KAWANISHI Yasuyuki

  公开号：US20100292500A1

  公开（公告）日：2010-11-18

  The present invention provides a pharmaceutical composition for use as art NPY Y5 receptor antagonist comprising a compound or the formula (I): wherein R 1 is lower alkyl, cycloalkyl or the like, R 2 is hydrogen, lower alkyl or the like, n is 1 or 2, X is lower alkylene, lower alkenylene, arylene, cycloalkylene or the like, Y is CONR 7 , CSNR 7 , NR 7 CO, NR 7 CS or the like, Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like and R 7 is hydrogen or lower alkyl, prodrug, pharmaceutically acceptable salt or solvate thereof.

  本发明提供了一种药物组合物，用作NPY Y5受体拮抗剂，包括化合物或式（I）：其中R1为低碳基、环烷基或类似物，R2为氢、低碳基或类似物，n为1或2，X为低碳基、低烯基、芳基、环烷基或类似物，Y为CONR7、CSNR7、NR7CO、NR7CS或类似物，Z为低碳基、可选取代的碳环基、可选取代的杂环基或类似物，R7为氢或低碳基，前药、药学上可接受的盐或溶剂。
• Photographic elements with tetra-nuclear merocyanine sensitizers
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0735415A1

  公开（公告）日：1996-10-02

  A photographic element comprising a light sensitive silver halide emulsion sensitized with a dye of formula (I) and a nucleating agent or amine booster associated with the silver halide emulsion: wherein: R3 is an alkyl group, alkenyl group, or aryl group R4 and R5 are each hydrogen, an alkyl group, alkenyl or aryl group; R6, R7 and R8 are, independently, an alkyl group, alkenyl group, aryl group, or H; the dye has at least three acid or acid salt substituents; and each L independently represents a methine group; p is 0 or 1; Z1 represents the atoms necessary to complete a 5- or 6-membered heterocyclic ring group; (X)n represents counterions as needed to balance the charge on the molecule. The present invention also provides a process for forming a high contrast photographic image on a photographic element having a light sensitive silver halide emulsion sensitized with a dye of formula (I). The process comprises developing such a photographic element in the presence of a hydrazine compound and an amine booster.

  一种感光元件，包括用式 (I) 染料感光的卤化银乳剂和与卤化银乳剂相关的成核剂或胺增效剂： 其中 R3 是烷基、烯基或芳基 R4 和 R5 分别是氢、烷基、烯基或芳基； R6、R7 和 R8 分别是烷基、烯基、芳基或 H； 染料具有至少三个酸或酸式盐取代基；以及 每个 L 独立地代表一个甲基； p 为 0 或 1； Z1 代表完成 5 或 6 元杂环基团所需的原子； (X)n 代表平衡分子电荷所需的反离子。 本发明还提供了一种在具有用式（I）染料感光的光敏卤化银乳剂的照相元件上形成高对比度照相图像的工艺。该工艺包括在肼化合物和胺促进剂的存在下显影这种感光元件。
• Hydrazide compounds useful as co-developers for black-and-white thermographic elements
  申请人：Imation Corp.

  公开号：EP0940714A2

  公开（公告）日：1999-09-08

  Trityl hydrazides and formyl-phenyl hydrazines are useful as co-developers with hindered phenols in phothothermographic and thermographic elements. These co-developers have the formula:         R1-(C=O)n-NHNH-R2 R1 represents hydrogen and R2 represents an aryl or substituted aryl group; or, R1 represents hydrogen, alkyl and alkenyl groups of up to 20 carbon atoms; alkoxy, thioalkoxy, or amido groups of up to 20 carbon atoms; aryl, alkaryl, or aralkyl groups of up to 20 carbon atoms; aryloxy, thioaryloxy, or anilino groups of up to 20 carbon atoms; aliphatic or aromatic heterocyclic ring groups containing up to 6 ring atoms; carbocyclic ring groups comprising up to 6 ring carbon atoms; or fused ring or bridging groups comprising up to 14 ring atoms; and R2 represents a trityl group. The photothermographic and thermographic elements in the present invention may be used as a photomask in a process where there is a subsequent exposure of an ultraviolet or short wavelength visible radiation sensitive imageable medium.

  三苯甲基肼和甲酰基苯基肼可与受阻酚一起作为显影剂用于相热和热成像元件。这些共显影剂的化学式如下 R1-(C=O)n-NHNH-R2 R1 代表氢，R2 代表芳基或取代芳基；或 R1 代表氢、多达 20 个碳原子的烷基和烯基；多达 20 个碳原子的烷氧基、硫代烷氧基或氨基；多达 20 个碳原子的芳基、烷芳基或芳烷基；多达 20 个碳原子的芳氧基、硫代芳氧基或苯胺基；含有多达 6 个环原子的脂肪族或芳香族杂环基团；含有多达 6 个环碳原子的碳环基团；或含有多达 14 个环原子的熔合环或桥基；以及 R2 代表三烷基。 本发明中的光热成像和热成像元件可在随后对紫外线或短波长可见光辐射敏感的可成像介质进行曝光的工艺中用作光掩膜。
• BUTKIEWICZ, K.;WOJCJECHOWSKI, J.;PAKULA, R., ARCH. PHARM., 1982, 315, N 1, 83-86
  作者：BUTKIEWICZ, K.、WOJCJECHOWSKI, J.、PAKULA, R.

  DOI：——

  日期：——
• BINIECKI, S.;JAKUBOWSKI, J., ACTA POL. PHARM., 1982, 39, N 1-3, 9-14
  作者：BINIECKI, S.、JAKUBOWSKI, J.

  DOI：——

  日期：——