N-(4-fluorobenzoyl)isobutyrylmethylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-fluorobenzoyl)isobutyrylmethylamine
• 英文别名: 4-fluoro-N-(3-methyl-2-oxobutyl)benzamide
• 化学式: C₁₂H₁₄FNO₂
• 分子量: 223.247
• InChiKey: UQBBGSHTYRAANU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(4-fluorobenzoyl)isobutyrylmethylamine 、 溴乙酸乙酯 以90%的产率得到ethyl 3-(4-fluorobenzoylamino)-3-isobutyrylpropionate
  参考文献：
  名称：

  Alkyloxazolylacetic acid derivative for the treatment of hyperlipidemia

  摘要：

  一种化学式为：##STR1##的烷氧噁唑基乙酸衍生物，其中环A为苯或卤代苯，R.sup.1为1至5个碳原子的低烷基，R.sup.2为氢或1至3个碳原子的低烷基。该化合物（I）可用作降血脂药物。

  公开号：

  US04535089A1
• 作为产物：
  描述：

  对氟苯甲酰氯 、 1-amino-3-methylbutan-2-one hydrochloride 在 碳酸氢钠 作用下， 以89.2%的产率得到N-(4-fluorobenzoyl)isobutyrylmethylamine
  参考文献：
  名称：

  Alkyloxazolylacetic acid derivative for the treatment of hyperlipidemia

  摘要：

  一种化学式为：##STR1##的烷氧噁唑基乙酸衍生物，其中环A为苯或卤代苯，R.sup.1为1至5个碳原子的低烷基，R.sup.2为氢或1至3个碳原子的低烷基。该化合物（I）可用作降血脂药物。

  公开号：

  US04535089A1

文献信息

• Novel alkyloxazolylacetic acid derivative, processes for preparation and pharmaceutical compositions containing same
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP0094612A2

  公开（公告）日：1983-11-23

  An alkyloxazolylacetic acid derivative of the formula: wherein Ring A is phenyl or halogenophenyl, R' is lower alkyl of one to 5 carbon atoms and R2 is hydrogen or lower alkyl of one to 3 carbon atoms as well as pharmaceutical compositions containing same. The compound (I) is useful as a hypolipidemic agent.

  式中的烷基噁唑乙酸衍生物： 其中环 A 是苯基或卤代苯基，R'是 1 至 5 个碳原子的低级烷基，R2 是氢或 1 至 3 个碳原子的低级烷基，以及含有这种衍生物的药物组合物。化合物（I）可用作降血脂药。
• OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING
  申请人：Suzuki Hideyuki

  公开号：US20100256355A1

  公开（公告）日：2010-10-07

  The present invention provides a novel oxazolidinone derivative of the formula (I): wherein Ring A is (A-1) a 7-membered monocyclic heterocycle containing three N atoms; (A-2) a 7-membered monocyclic heterocycle containing two N atoms and one O atom; or (A-3) a 7-membered monocyclic heterocycle containing two N atoms and one S atom, SO or SO 2 , wherein said monocyclic heterocycle is optionally substituted, optionally unsaturated and optionally fused with another ring; X 1 is a single bond, or a heteroatom-containing group selected from the group consisting of —O—, —S—, —NR 2 —, —CO—, —CS—, —CONR 3 —, —NR 4 CO—, —SO 2 NR 5 —, and —NR 6 SO 2 —, wherein R 2 , R 3 , R 4 , R 5 and R 6 are independently hydrogen or lower alkyl, or lower alkylene or lower alkenylene each optionally interrupted by said heteroatom-containing group; Ring B is optionally substituted carbocycle or optionally substituted heterocycle; and R 1 is hydrogen, or an organic residue which is able to bind to the 5 -position of the oxazolidinone ring in oxazolidinone antimicrobial agents, pharmaceutically acceptable salts and solvates thereof which are useful as an antibacterial agent.
• US4535089A
  申请人：——

  公开号：US4535089A

  公开（公告）日：1985-08-13
• US8530646B2
  申请人：——

  公开号：US8530646B2

  公开（公告）日：2013-09-10
• Alkyloxazolylacetic acid derivative for the treatment of hyperlipidemia
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US04535089A1

  公开（公告）日：1985-08-13

  A alkyloxazolylacetic acid derivative of the formula: ##STR1## wherein Ring A is phenyl or halogenophenyl, R.sup.1 is lower alkyl of one to 5 carbon atoms and R.sup.2 is hydrogen or lower alkyl of one to 3 carbon atoms. The compound (I) is useful as a hypolipidemic agent.

  一种化学式为：##STR1##的烷氧噁唑基乙酸衍生物，其中环A为苯或卤代苯，R.sup.1为1至5个碳原子的低烷基，R.sup.2为氢或1至3个碳原子的低烷基。该化合物（I）可用作降血脂药物。