2-cyano-3,3-dimercapto-N-phenylacrylamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-cyano-3,3-dimercapto-N-phenylacrylamide
• 英文别名: 2-cyano-N-phenyl-3,3-bis(sulfanyl)prop-2-enamide
• 化学式: C₁₀H₈N₂OS₂
• 分子量: 236.318
• InChiKey: GWKHZXHCGRLMCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-cyano-3,3-dimercapto-N-phenylacrylamide 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 4-amino-5-benzoyl-2-methylsulfanyl-N-phenylthiophene-3-carboxamide
  参考文献：
  名称：

  α‐Cyanodithioic Acids and Their Corresponding Mono‐ and Dithiolate Salts as Building Blocks for the Synthesis of Novel Mercaptothiophenes

  摘要：

  A novel and efficient method for the synthesis of mercaptothiophenes using cyanodithioic acids and their corresponding mono- and dithiolate salts as starting components is described.

  DOI：

  10.1080/00397910500503348
• 作为产物：
  描述：

  二硫化碳 、 2-氰基乙酰苯胺 在 sodium ethanolate 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 生成 2-cyano-3,3-dimercapto-N-phenylacrylamide
  参考文献：
  名称：

  First Synthesis of Thiophene Thioglycosides

  摘要：

  A new method for the preparation of a new class of thiophene thioglycosides via one-pot reaction of the sodium thiophenethiolate salts with 2,3,4,6-tetra-O-acetyl--D-gluco- and galacto-pyranosyl bromides has been studied. The sodium thiophenethiolate salts are prepared using cyano-di-thioic analogs and their corresponding mono- and dithiolate salts.

  DOI：

  10.1080/07328300902789209

文献信息

• First Synthesis of Thiophene Thioglycosides
  作者：Galal H. Elgemeie、Wafaa A. Zaghary、Kamelia M. Amin、Tamer M. Nasr

  DOI：10.1080/07328300902789209

  日期：2009.4.7

  A new method for the preparation of a new class of thiophene thioglycosides via one-pot reaction of the sodium thiophenethiolate salts with 2,3,4,6-tetra-O-acetyl--D-gluco- and galacto-pyranosyl bromides has been studied. The sodium thiophenethiolate salts are prepared using cyano-di-thioic analogs and their corresponding mono- and dithiolate salts.
• α‐Cyanodithioic Acids and Their Corresponding Mono‐ and Dithiolate Salts as Building Blocks for the Synthesis of Novel Mercaptothiophenes
  作者：Galal H. Elgemeie、Mohamed A. Mohamed

  DOI：10.1080/00397910500503348

  日期：2006.5

  A novel and efficient method for the synthesis of mercaptothiophenes using cyanodithioic acids and their corresponding mono- and dithiolate salts as starting components is described.