6-(1H-pyrazol-1-yl)nicotinic aldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(1H-pyrazol-1-yl)nicotinic aldehyde
• 英文别名: 6-(1H-pyrazol-1-yl)nicotinaldehyde；6-pyrazol-1-ylpyridine-3-carbaldehyde
• 化学式: C₉H₇N₃O
• 分子量: 173.174
• InChiKey: XPCKEWUGNBMESY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(1H-pyrazol-1-yl)nicotinic aldehyde 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以13.4 g的产率得到(6-(1H-吡唑-1-基)吡啶-3-基)甲醇
  参考文献：
  名称：

  NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

  摘要：

  公开号：

  EP3156397B1
• 作为产物：
  描述：

  吡唑 、 2-溴-5-醛基吡啶 在 potassium carbonate 作用下， 反应 18.0h， 以53.7%的产率得到6-(1H-pyrazol-1-yl)nicotinic aldehyde
  参考文献：
  名称：

  WO2019079519A5

  摘要：

  公开号：

  WO2019079519A5

文献信息

• NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF
  申请人：FUJIFILM Corporation

  公开号：US20160168139A1

  公开（公告）日：2016-06-16

  There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z 2 represents CH or the like; Z 1 represents CR 6 or the like; R 6 represents a hydrogen atom or the like; X 1 represents CHR 7 or the like; R 7 represents a hydrogen atom or the like; X 2 represents CH 2 or the like; R 1 and R 2 are the same as or different from each other, and each of R 1 and R 2 represents a hydrogen atom or the like; R 3 , R 4 , and R 5 are the same as or different from each other, and each of R 3 , R 4 , and R 5 represents a hydrogen atom, NR a R b , or the like; and each of R a and R b represents a hydrogen atom, a C 1-8 alkyl group which may have a substituent, or the like.)

  提供一种由通用式[1A]表示的吗啉衍生物或其盐。 （在该式中，环A代表由通用式[I]表示的环；*代表连接位置；Z 2 代表CH或类似物；Z 1 代表CR 6 或类似物；R 6 代表氢原子或类似物；X 1 代表CHR 7 或类似物；R 7 代表氢原子或类似物；X 2 代表CH 2 或类似物；R 1 和R 2 相同或不同，且R 1 和R 2 中的每一个代表氢原子或类似物；R 3 ，R 4 和R 5 相同或不同，且R 3 ，R 4 和R 5 中的每一个代表氢原子，NR a R b 或类似物；R a 和R b 中的每一个代表氢原子，可能具有取代基的C 1-8 烷基基团，或类似物。）
• Broad spectrum antiviral compositions and methods
  申请人：Evrys Bio, LLC

  公开号：US11459321B2

  公开（公告）日：2022-10-04

  Novel thiazole- and isoquinoline-containing compounds are presented that are useful for treating and/or preventing broad-spectrum viral infections. Methods of treating and/or preventing broad-spectrum viral infections are also presented. These compounds have shown inhibition of HCMV, influenza viruses, Zika virus, BK Virus and RSV replication in cell-based assays.

  本文介绍了可用于治疗和/或预防广谱病毒感染的新型含噻唑和异喹啉化合物。还介绍了治疗和/或预防广谱病毒感染的方法。这些化合物在基于细胞的试验中显示出对 HCMV、流感病毒、寨卡病毒、BK 病毒和 RSV 复制的抑制作用。
• EP3929198
  申请人：——

  公开号：——

  公开（公告）日：——
• Broad Spectrum Antiviral Compositions and Methods
  申请人：Evrys Bio, LLC

  公开号：US20210139475A1

  公开（公告）日：2021-05-13

  Novel thiazole- and isoquinoline-containing compounds are presented that are useful for treating and/or preventing broad-spectrum viral infections. Methods of treating and/or preventing broad-specturm viral infections are also presented. These compounds have shown inhibition of HCMV, influenza viruses, Zika virus, BK Virus and RSV replication in cell-based assays.
• HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF
  申请人：Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

  公开号：US20220144847A1

  公开（公告）日：2022-05-12

  The present disclosure relates to a heterocyclic compound, a pharmaceutical composition comprising same, a preparation method therefor, and a use thereof. Specifically, the compound of the present invention is represented by formula (I), and used for preventing or treating a disease or condition related to RET activity.