glyceryl-1-monoacetoacetate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: glyceryl-1-monoacetoacetate
• 英文别名: 1,4-but-2-enediol；AC-0523；acetoacetyl glycerol；monoacetoacetin；2,3-Dihydroxypropyl 3-oxobutanoate
• 化学式: C₇H₁₂O₅
• 分子量: 176.169
• InChiKey: BJXWCJCOADTGSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-氧丁酸 、 甘油 在 potassium acetoacetate 作用下， 生成 glyceryl-1-monoacetoacetate
  参考文献：
  名称：

  乙酰乙酸甘油酯对兔直肠中胰岛素和菊粉吸收的佐剂作用。

  摘要：

  研究了乙酰乙酸甘油酯对胰岛素和菊粉直肠吸收的促进作用。给予含1,3-二乙酰乙酸甘油酯（佐剂II）或1,2-异亚丙基甘油-3-乙酰乙酸酯（佐剂IV）的胰岛素栓剂后，兔体内的血清葡萄糖水平降低。通过向栓剂中添加钙和镁，抑制了佐剂II和IV对胰岛素和菊粉的直肠吸收的促进作用。这表明与直肠膜中钙和镁离子的佐剂相互作用与胰岛素和菊粉的吸收增强有关。

  DOI：

  10.1002/jps.2600720318

文献信息

• [EN] N-OXIDES OF 4,5-EPOXY-MORPHINANIUM ANALOGS<br/>[FR] N-OXYDES D'ANALOGUES 4,5-ÉPOXY-MORPHINANIUM
  申请人：PROGENICS PHARM INC

  公开号：WO2009067275A1

  公开（公告）日：2009-05-28

  Novel N-oxides of 4,5-epoxy-morphinanIum analogs are disclosed. Pharmaceutical compositions containing the N-oxides of 4,5-epoxy-morphinanium analogs and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as modulators of opioid receptors.

  揭示了4,5-环氧吗啡啉盐类的新型N-氧化物。还揭示了含有4,5-环氧吗啡啉盐类的N-氧化物的药物组合物，以及它们的药用方法。所揭示的化合物可用作阿片受体调节剂等用途。
• Therapeutic compositions (II)
  申请人：——

  公开号：US20010014696A1

  公开（公告）日：2001-08-16

  Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, inter alia, (i) increasing cardiac efficiency, particularly efficiency in use of glucose, (ii) for providing energy source, particularly in diabetes and insulin resistant states and (iii) treating disorders caused by damage to brain cells, particularly by retarding or preventing brain damage in memory associated brain areas such as found in Alzheimer's and similar conditions. These compositions may be taken as nutritional aids, for example for athletes, or for the treatment of medical conditions, particularly those associated with poor cardiac efficiency, insulin resistance and neuronal damage. The invention further provides methods of treatment and novel esters and polymers for inclusion in the compositions of the invention.

  提供了包含酮体及/或其代谢前体的组合物，适用于人类和动物，并具有如下特性：(i)增加心脏效率，特别是在葡萄糖利用方面的效率，(ii)提供能源来源，尤其是在糖尿病和胰岛素抵抗状态下，以及(iii)治疗由脑细胞损伤引起的疾病，特别是通过延缓或预防阿尔茨海默病等疾病中的与记忆相关的脑区域的脑损伤。这些组合物可以作为营养辅助剂使用，例如用于运动员，或用于治疗医疗状况，特别是与心脏效率低下、胰岛素抵抗和神经元损伤相关的状况。该发明还提供了治疗方法和用于包含在该发明组合物中的新酯和聚合物。
• ISOMETHEPTENE ISOMER
  申请人：TONIX PHARMACEUTICALS INC.

  公开号：US20140212486A1

  公开（公告）日：2014-07-31

  The invention relates to a purified Isometheptene compound comprising the structure according to Formula (I), or a hydrochloride, or a pharmaceutically acceptable addition salt thereof. In particular, the disclosure relates to the synthesis, purification and characterization of an Isometheptene isomer mucate crystal 2, wherein the Isometheptene isomer 2 is stereochemically characterized as (R)-enantiomer, respectively. The Isometheptene (R)-enantiomer activity indicates a selective centrally acting selective ligand for Imidazoline subtype 1 (I1) receptor sites; and more specifically, the disclosure provides an antihypertensive composition for treatment of migraine and other neurovascular or neurogenic pain from abdominal distress. (R)-Isometheptene enantiomer or isomer 2 may be an anti-hypertensive agent with lower side effects than the racemate form. Therefore (R)-Isometheptene is believed to be effective against episodic tension-type headaches (ETTH). The (R)-Isometheptene enantiomer or isomer 2 is believed to effectively lower blood pressure, used alone or together with other headache ameliorating drugs. Methods of synthesis and treatment are described. Regarding (R)-Isometheptene crystals data of X-ray crystallography are presented.

  该发明涉及一种纯化的异甲苯丙胺化合物，其结构符合式(I)，或其盐酸盐，或其药用上可接受的加合物。具体而言，该公开涉及异甲苯丙胺异构体粘酸晶体2的合成、纯化和表征，其中异甲苯丙胺异构体2的立体化学特性为(R)-对映体。异甲苯丙胺(R)-对映体活性表明其为咪唑啉亚型1(I1)受体位点的选择性中枢作用选择性配体；更具体地，该公开提供了一种用于治疗偏头痛和其他源自腹部不适的神经血管性或神经源性疼痛的降压组合物。异甲苯丙胺(R)-对映体或异构体2可能是一种抗高血压药物，其副作用较盐酸异甲苯丙胺的形式更少。因此，人们认为异甲苯丙胺(R)对映体对阵发性张力型头痛(ETTH)有效。异甲苯丙胺(R)对映体或异构体2被认为能有效降低血压，可单独使用或与其他缓解头痛药物一起使用。描述了合成和治疗方法。关于异甲苯丙胺(R)晶体的X射线衍射数据已被提供。
• (S)-N-Stereoisomers of 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs
  申请人：Perez Julio

  公开号：US20080207669A1

  公开（公告）日：2008-08-28

  Novel (S)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs are disclosed. Pharmaceutical compositions containing the (S)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs and methods for their pharmaceutical uses are also disclosed. Such analogs are disclosed as being useful in treating, among varying conditions, hypermotility of the gastrointestinal tract.

  本专利揭示了7,8-饱和-4,5-环氧-吗啡盐类的（S）-N-立体异构体。还揭示了含有7,8-饱和-4,5-环氧-吗啡盐类（S）-N-立体异构体的药物组合物，以及其药用方法。这些类似物被发现可用于治疗多种情况，包括胃肠道过度运动。
• [EN] METHOD FOR THE PREPARATION OF TRIS-(3-HYDROXYBUTYRATO)-GLYCERYL ESTER<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ESTER TRIS-(3-HYDROXYBUTYRATO)-GLYCÉRIQUE
  申请人：DR SCHAER S P A

  公开号：WO2021070208A1

  公开（公告）日：2021-04-15

  The present invention concerns a method to prepare and purify the ester glyceryl-tris-(3 -hydroxy butyrate) of formula (I) and its optically active isomers, in particular the enantiomer (R, R, R).

  本发明涉及一种制备和纯化式(I)的甘油三酯-(3-羟基丁酸酯)及其光学活性异构体的方法，特别是对映异构体(R, R, R)的方法。