7-[(Hydroxyimino)methyl]-2H-1-benzopyran-2-one | 675616-73-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-[(Hydroxyimino)methyl]-2H-1-benzopyran-2-one
• 英文别名: 7-(hydroxyiminomethyl)chromen-2-one
• CAS: 675616-73-6
• 化学式: C₁₀H₇NO₃
• 分子量: 189.17
• InChiKey: DHLZAIWLWKDPJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  7-甲基香豆素 在 selenium(IV) oxide 、 盐酸羟胺 、 sodium acetate 作用下， 以 乙醇 为溶剂， 生成 7-[(Hydroxyimino)methyl]-2H-1-benzopyran-2-one
  参考文献：
  名称：

  Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage

  摘要：

  The synthesis of several novel coumarin derivatives with a 7-azomethine linkage was carried out starting from 7-formylcoumarin. The compounds were tested in vivo for their anti-inflammatory activity and in vitro for their antioxidant ability. Compounds 3a and 3e possess significant protection against carrageenin induced rat paw edema. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.11.060

文献信息

• Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage
  作者：Christos A. Kontogiorgis、Dimitra J. Hadjipavlou-Litina

  DOI：10.1016/j.bmcl.2003.11.060

  日期：2004.2

  The synthesis of several novel coumarin derivatives with a 7-azomethine linkage was carried out starting from 7-formylcoumarin. The compounds were tested in vivo for their anti-inflammatory activity and in vitro for their antioxidant ability. Compounds 3a and 3e possess significant protection against carrageenin induced rat paw edema. (C) 2003 Elsevier Ltd. All rights reserved.