2-(5,5-dimethyl-5,6-dihydro-2H-[1,3]oxazin-2-yl)-2-methyl-propan-1-ol | 91016-91-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环化合物
• 英文名称: 2-(5,5-dimethyl-5,6-dihydro-2H-[1,3]oxazin-2-yl)-2-methyl-propan-1-ol
• 英文别名: 2-(5,5-Dimethyl-2,6-dihydro-1,3-oxazin-2-yl)-2-methylpropan-1-ol
• CAS: 91016-91-0
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: XLQRNKAMTXDLAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(5,5-dimethyl-5,6-dihydro-2H-[1,3]oxazin-2-yl)-2-methyl-propan-1-ol 生成 13-Aza-4,4,8,8,12,12-hexamethyl-2,6,10-trioxatricyclo<7,3,1,0^5,13>tridecane
  参考文献：
  名称：

  Notes-The Reaction Product of Hydroxypivalaldehyde and Ammonia

  摘要：

  DOI：

  10.1021/jo01068a618
• 作为产物：
  描述：

  2,2-二甲基-3-羟基丙醛 在 氨 作用下， 以 氯仿 为溶剂， 反应 18.0h， 以20%的产率得到2-(5,5-dimethyl-5,6-dihydro-2H-[1,3]oxazin-2-yl)-2-methyl-propan-1-ol
  参考文献：
  名称：

  A new 5,6-dihydro-2H-1,3-oxazine synthesis via Asigner-type condensation

  摘要：

  In this article - which we dedicate to the lifework1 of Professor Teruaki Mukaiyama - a new general 5,6-dihydro-2H-1,3-oxazine synthesis is described. 3-Hydroxy-2,2-dimethylpropionaldehyde is condensed with a second oxo component and ammonia to the title compound in several examples. In the case of citronellal diastereoselectivity is observed.

  DOI：

  10.1016/s0040-4020(01)80219-2

文献信息

• A new 5,6-dihydro-2H-1,3-oxazine synthesis via Asigner-type condensation
  作者：Alexander Dömling、Ivar K. Ugi

  DOI：10.1016/s0040-4020(01)80219-2

  日期：——

  In this article - which we dedicate to the lifework1 of Professor Teruaki Mukaiyama - a new general 5,6-dihydro-2H-1,3-oxazine synthesis is described. 3-Hydroxy-2,2-dimethylpropionaldehyde is condensed with a second oxo component and ammonia to the title compound in several examples. In the case of citronellal diastereoselectivity is observed.
• Spaeth; v. Szilagyi, Monatshefte fur Chemie, 1946, vol. 76, p. 77,80, 81
  作者：Spaeth、v. Szilagyi

  DOI：——

  日期：——
• Spaeth; v.Szilagyi, Monatshefte fur Chemie, 1947, vol. 76, p. 77,80
  作者：Spaeth、v.Szilagyi

  DOI：——

  日期：——
• MCR V: the Seven-Component Reaction.
  作者：Alexander Dömling、Eberhardt Herdtweck、Ivar Ugi、Larry L. Miller、Giovanni V. Sebastiani、George W. Francis、József Szúnyog、Bengt Långström

  DOI：10.3891/acta.chem.scand.52-0107

  日期：——

  The following payer describes the reaction of seven different starting materials for the formation of one product. This reaction is a union of two multicomponent reactions (MCR): the Asinger and the Ugi reaction. The number of possible, highly diverse products of unions of such MCRs is immense.
• Notes-The Reaction Product of Hydroxypivalaldehyde and Ammonia
  作者：Robert Hasek、James Martin

  DOI：10.1021/jo01068a618

  日期：1961.10