1H,1H-perfluorooctyl-2-bromoisobutyrate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1H,1H-perfluorooctyl-2-bromoisobutyrate
• 英文别名: 2-bromo-2-methylbutyrylic acid-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctyl) ester；2-Bromo-2-methylpropanoic acid 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctyl ester；2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctyl 2-bromo-2-methylpropanoate
• 化学式: C₁₂H₈BrF₁₅O₂
• 分子量: 549.074
• InChiKey: IVEHJSIZNSFHCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  17

反应信息

• 作为产物：
  描述：

  2-溴-2-甲基丙酰溴 、 1H,1H-perfluorooctyl bromide 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 8.0h， 生成 1H,1H-perfluorooctyl-2-bromoisobutyrate
  参考文献：
  名称：

  Blends of polystyrene and poly(n-butyl methacrylate) mediated by perfluorocarbon end groups

  摘要：

  Structurally well-defined C4F9, C7F15, C10F21 and C13F27 end-functionalized polystyrene (RF-PS) and polybutylmethacrylate (RF-PBMA) were prepared by Atom Transfer Radical Polymerization using RF-tagged initiators. Blends (1/1 wt/wt) of these polymers were studied by differential scanning calorimetry (DSC), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), optical transmittance(OT), electron microscopy (TEM) and optical transmittance (OT). The RF-PS/RF-PBMA blends having molecular weights of 20,000 and C7F15 or larger end groups, were optically transparent. The AFM micrographs show crater, necklace and other RF mediated morphologies typically at the submicron scale. TEM images of the corresponding blends show assembly of elongated domains with sizes in the micron or nanometer scales depending on MW and RF size. Thus, above about 3 wt percent RF content only microphases (m) are observed while below 1.8 wt percent only macrophases (M) are seen. A semiquantitative "phase diagram" of the blends shows that lower MWs and longer RF groups improve phase compatibilities. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2013.08.059

文献信息

• Controlling the Hydration Structure with a Small Amount of Fluorine To Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate)
  作者：Ryohei Koguchi、Katja Jankova、Noriko Tanabe、Yosuke Amino、Yuki Hayasaka、Daisuke Kobayashi、Tatsuya Miyajima、Kyoko Yamamoto、Masaru Tanaka

  DOI：10.1021/acs.biomac.9b00201

  日期：2019.6.10

  manipulating the surface hydration structure of PMEA by incorporation of small amounts of hydrophobic fluorine groups in MEA polymers using atom-transfer radical polymerization and the (macro) initiator concept. Two kinds of fluorinated MEA polymers with similar molecular weights and the same 5.5 mol % of fluorine content were synthesized using the bromoester of 2,2,3,3,4,4,5,5,6,6,7,7,8,8-pentadecafluoro-1-octanol

  聚（2-甲基丙烯酸甲氧基乙酯）（PMEA）由于存在中间水而具有出色的血液相容性。通过改变PMEA主链或侧链的化学结构，对PMEA进行了各种修改，从而可以调节许多新型聚合物的水含量和血液相容性。在这里，我们利用原子转移自由基聚合和（宏观）引发剂概念，通过在MEA聚合物中引入少量疏水性氟基团来操纵PMEA的表面水合结构。使用2,2,3,3,4,4,5,5,6,6,7,7,8,2的溴酸酯合成了两种具有相似分子量和相同5.5 mol％氟含量的氟化MEA聚合物，8-十五氟-1-辛醇（F15）和聚（2,2,2-三氟甲基丙烯酸甲酯）（PTFEMA）作为（宏观）引发剂，在室温下分别呈液态和固态。两种氟化MEA聚合物对纤维蛋白原的吸附是不同的，这不能仅通过本体水合结构来解释。两种聚合物在水合状态下均显示出具有不同尺寸特征的纳米结构形态。在原子力显微镜下测得的域的弹性模量和中间水含量阐明了血液相容性的独特机理
• FLUOROCARBON MEDIATED POLYMER BLENDS AND METHODS FOR MAKING THEREOF
  申请人：Hogen-Esch Thieo

  公开号：US20080093283A1

  公开（公告）日：2008-04-24

  The present invention discloses a method for making blended polymers by utilizing fluorophilic inter-polymer associative interactions between perfluorocarbon functional groups attached on the constituent polymers. The method of the present invention is capable of forming blended polymers from otherwise incompatible polymers. Also disclosed are blended polymers obtained by the method thereof. Methods and devices utilizing novel blended polymer of the present invention including chromatography, catalysis, photonic and sensor applications are also provided.
• US8236902B2
  申请人：——

  公开号：US8236902B2

  公开（公告）日：2012-08-07
• Blends of polystyrene and poly(n-butyl methacrylate) mediated by perfluorocarbon end groups
  作者：Jingguo Shen、Victoria A. Piunova、Steven Nutt、Thieo E. Hogen-Esch

  DOI：10.1016/j.polymer.2013.08.059

  日期：2013.10

  Structurally well-defined C4F9, C7F15, C10F21 and C13F27 end-functionalized polystyrene (RF-PS) and polybutylmethacrylate (RF-PBMA) were prepared by Atom Transfer Radical Polymerization using RF-tagged initiators. Blends (1/1 wt/wt) of these polymers were studied by differential scanning calorimetry (DSC), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), optical transmittance(OT), electron microscopy (TEM) and optical transmittance (OT). The RF-PS/RF-PBMA blends having molecular weights of 20,000 and C7F15 or larger end groups, were optically transparent. The AFM micrographs show crater, necklace and other RF mediated morphologies typically at the submicron scale. TEM images of the corresponding blends show assembly of elongated domains with sizes in the micron or nanometer scales depending on MW and RF size. Thus, above about 3 wt percent RF content only microphases (m) are observed while below 1.8 wt percent only macrophases (M) are seen. A semiquantitative "phase diagram" of the blends shows that lower MWs and longer RF groups improve phase compatibilities. (C) 2013 Elsevier Ltd. All rights reserved.