2,6-二甲基苯-1,3,5-三胺 | 94135-19-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,6-二甲基苯-1,3,5-三胺
• 中文别名: (8S,9S)-4-(羟甲基)-8,9-二氢四芬-8,9-二醇
• 英文名称: 2,4-dimethyl-benzene-1,3,5-triyltriamine
• 英文别名: 2,4-Dimethyl-benzen-1,3,5-triyltriamin；2.4.6-Triamino-m-xylol；2,6-dimethylbenzene-1,3,5-triamine；2,4-dimethylbenzene-1,3,5-triamine
• CAS: 94135-19-0
• 化学式: C₈H₁₃N₃
• 分子量: 151.211
• InChiKey: GKZWSNRSZYTGJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  78.1
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2921590090

反应信息

• 作为反应物：
  描述：

  2,6-二甲基苯-1,3,5-三胺 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 24.0h， 以62%的产率得到二甲基均苯三酚
  参考文献：
  名称：

  Synthesis and biological activity of flavanone derivatives

  摘要：

  A series of new flavanone derivatives of farrerol was synthesized by a convenient method. The in vitro anti-tumor activity of these compounds was evaluated against human Bel-7402, HL-60, BGC-823 and KB cell lines, the protein tyrosine kinase (PTK) inhibitor activity was also tested. Their cytoprotective activity was tested using hydrogen peroxide (H2O2)-induced injury in human umbilical vein endothelial cells. Their in vitro anti-atherosclerosis activity was tested on vascular smooth muscle cells by the MTT method using tetrandrine as a positive contrast drug. The structures of all compounds synthesized were confirmed by H-1, C-13 NMR and ESI-MS. Most of the compounds exhibited good pharmacological activity and the preliminary structure-activity relationships were described. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.090
• 作为产物：
  描述：

  1,3-二甲基-2,4-二硝基苯 在 盐酸 、 硫酸 、 硝酸 、 tin(ll) chloride 作用下， 生成 2,6-二甲基苯-1,3,5-三胺
  参考文献：
  名称：

  Grevingk, Chemische Berichte, 1884, vol. 17, p. 2423

  摘要：

  DOI：

文献信息

• Pharmaceutical compositions containing compounds with a flavanone skeleton and process for the preparation of said compounds
  申请人：INVERNI DELLA BEFFA S.P.A.

  公开号：EP0122053A2

  公开（公告）日：1984-10-17

  Compounds with a flavanone skeleton having the formula I in which R1 and R2, which may be the same or different, represent hydrogen, hydroxyl, methoxyl, thiomethyl, amino or substituted amino, are endowed with expectorant, mucolytic, mucopoietic, chloretic and hypolipaemia-producing activity.

  具有式 I 的黄烷酮骨架的化合物，其中 R1 和 R2（可以相同或不同）代表氢、羟基、甲氧基、硫甲基、氨基或取代氨基，具有祛痰、粘液溶解、粘液造血、软化胆囊和降血脂活性。
• Actinic radiation-curable urethane/urea-containing aerospace coatings and sealants
  申请人：PRC-DeSoto International, Inc.

  公开号：US10883016B2

  公开（公告）日：2021-01-05

  Actinic radiation-curable compositions containing polythiols and urethane/urea-containing polyalkenyl prepolymers that can be used for aerospace coatings and sealants. The coatings can be applied to surfaces and rapidly cured.

  辐照固化组合物含有可用于航空涂层和密封剂的聚硫醇和含脲/脲的聚亚烷基预聚物。这种涂料可涂于表面并迅速固化。
• Weidell; Wenzel, Monatshefte fur Chemie, 1898, vol. 19, p. 237
  作者：Weidell、Wenzel

  DOI：——

  日期：——
• The Reduction of 2,4,6-Trinitro-m-xylene
  作者：Stephen S. Voris、Paul E. Spoerri

  DOI：10.1021/ja01271a052

  日期：1938.4
• Beilstein; Luhmann, Justus Liebigs Annalen der Chemie, 1867, vol. 144, p. 277
  作者：Beilstein、Luhmann

  DOI：——

  日期：——