(Z)-4-bromobenzaldehyde oxime | 25062-46-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-4-bromobenzaldehyde oxime
• 英文别名: (Z)-p-Bromobenzaldehyde oxime；(NZ)-N-[(4-bromophenyl)methylidene]hydroxylamine
• CAS: 25062-46-8
• 化学式: C₇H₆BrNO
• 分子量: 200.035
• InChiKey: UIIZGAXKZZRCBN-UITAMQMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  (Z)-4-bromobenzaldehyde oxime 在 aluminum oxide 、 ammonium chlorochromate 作用下， 反应 2.5h， 以45%的产率得到对溴苯甲醛
  参考文献：
  名称：

  Oxidative Deoximation to Their Parent Carbonyl Compounds with Ammonium Chlorochromate Adsorbed on Alumina

  摘要：

  A convenient method for the oxidative cleavage of oximes to their parent aldehydes and ketones with ammonium chlorochromate adsorbed on alumina is described.

  DOI：

  10.1080/00397919808007037
• 作为产物：
  描述：

  对溴苯甲醛 在 盐酸羟胺 作用下， 以 水 为溶剂， 反应 0.04h， 以95%的产率得到(Z)-4-bromobenzaldehyde oxime
  参考文献：
  名称：

  An Eco-Friendly System for Oximation of Organic Carbonyl Compounds Under Microwave Irradiation

  摘要：

  在微波辐射下，使用NH2OH·HCl高效完成了多种有机羰基化合物的肟化反应。这些反应在水或水-乙醇绿色溶剂中进行，完美地选择性地生成了相应醛的Z-醛肟异构体和相应酮的E-酮肟异构体，产率极佳。

  DOI：

  10.13005/ojc/300241

文献信息

• [EN] ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS<br/>[FR] ARYLPYRAZOLES ET ARYLISOXAZOLES ET LEUR UTILISATION EN TANT QUE MODULATEURS DE LA PROTÉINE KINASE C (PKD)
  申请人：NOVARTIS AG

  公开号：WO2011009484A1

  公开（公告）日：2011-01-27

  The present invention provides novel organic compounds of formula (I) or (Ia): which may be inhibitors of a selective subset of kinases belonging to the AGC or calmodulin kinase family, such as for example PKD-1/2/3, inhibitors of histone deacetylase (HDAC) phosphorylation, or inhibitors of other kinases. The selectivity of which would depend on the structural variation thereof, and for treatment of a disorder or disease mediated by those selected AGC or calmodulin family kinases. These organic compounds can be used to treat various PKD associated states such as heart failure, colorectal cancer, regulation of cell growth, autoimmune disorders, or hyperproliferative skin disorders.

  本发明提供了化学式(I)或(Ia)的新型有机化合物：这些化合物可能是AGC或钙调素激酶家族中的一部分激酶的抑制剂，例如PKD-1/2/3，组蛋白去乙酰化酶（HDAC）磷酸化的抑制剂，或其他激酶的抑制剂。其选择性取决于其结构变化，用于治疗由这些选定的AGC或钙调素家族激酶介导的疾病或疾病。这些有机化合物可用于治疗各种PKD相关状态，如心力衰竭、结直肠癌、细胞生长调节、自身免疫性疾病或过度增生性皮肤疾病。
• X=Y–ZH Systems as potential 1,3-dipoles. Part 53: Sequential nucleophilic ring opening-1,3-dipolar cycloaddition reactions of Z-oxime anions with aziridines and dipolarophiles
  作者：H Ali Dondas、Jonathan E Cummins、Ronald Grigg、Mark Thornton-Pett

  DOI：10.1016/s0040-4020(01)00767-0

  日期：2001.9

  Nucleophilic ring opening of aziridines involving attack of the nitrogen atom of Z-oxime anions generates nitrones which are then trapped in 1,3-dipolar cycloaddition reactions with N-methylmaleimide to afford 1:1 mixture of endo- and exo-cycloadducts.

  涉及的氮原子的氮丙啶攻击亲核开环Ž肟阴离子生成硝酮，其然后被捕获在与1,3-偶极环加成反应Ñ -methylmaleimide，得到1：1个的混合物内切-和外切-cycloadducts。
• Aryl-isoxazol-4-yl-imidazole derivatives
  申请人：Buettelmann Bernd

  公开号：US20070161654A1

  公开（公告）日：2007-07-12

  The present invention is concerned with aryl-isoxazol-4-yl-imidazole derivatives of formula I: wherein R 1 to R 6 are as defmed in the specification and pharmaceutically acceptable acid addition salts thereof. This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

  本发明涉及式I的芳基异噁唑-4-基咪唑衍生物：其中R1至R6如规范中定义，并且其药用酸盐。这类化合物具有高亲和力和选择性结合到GABA A α5受体结合位点，可能有助于作为认知增强剂或治疗认知障碍如阿尔茨海默病。
• An Eco-Friendly System for Oximation of Organic Carbonyl Compounds Under Microwave Irradiation
  作者：Hana Batmani、Davood Setamdideh

  DOI：10.13005/ojc/300241

  日期：2014.7.1

  The oximation of a variety of organic carbonyl compounds was efficiently carried out with NH2OH·HCl under microwave irradiation. The reactions were performed in water or water-ethanol as green solvents to give Z-aldoxime isomers from the corresponding aldehydes and E-ketoxime isomers from the corresponding ketones in a perfect selectively with excellent yields.

  在微波辐射下，使用NH2OH·HCl高效完成了多种有机羰基化合物的肟化反应。这些反应在水或水-乙醇绿色溶剂中进行，完美地选择性地生成了相应醛的Z-醛肟异构体和相应酮的E-酮肟异构体，产率极佳。
• NH2OH.Hcl/Bacl2: A Convenient System for Synthesis of Oximes from The Corresponding of Organic Carbonyl Compounds
  作者：Farhad Talaei、Davood Setamdideh

  DOI：10.13005/ojc/320334

  日期：2016.6.28

  Oximes have many applications in organic synthesis1. These compounds have antimicrobial, antioxidant, antitumor, anti-depressive, antiviral agents, and anticonvulsant properties2-7. Some oximation methods have been reported8. However our ongoing attentions to the development of new modified methods in organic synthesis8-15, we have investigated the oximation of a variety of carbonyl compounds with

  肟在有机合成中有许多应用1。这些化合物具有抗微生物，抗氧化剂，抗肿瘤，抗抑郁，抗病毒药和抗惊厥特性2-7。已经报道了一些肟化方法8。但是，由于我们对有机合成中新的改良方法的开发的持续关注，我们研究了在BaCl2存在下用NH2OH·HCl氧化多种羰基化合物的方法。结果与讨论