3,6-二硝基苯二甲酸 | 2300-16-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,6-二硝基苯二甲酸
• 英文名称: 3,6-dinitrobenzene-1,2-dioic acid
• 英文别名: 3,6-dinitrophthalic acid；3,6-Dinitro-phthalsaeure
• CAS: 2300-16-5
• 化学式: C₈H₄N₂O₈
• 分子量: 256.128
• InChiKey: MZDSOZBFTCRKNT-UHFFFAOYSA-N

物化性质

• 沸点：
  495.2±45.0 °C(Predicted)
• 密度：
  1.853±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  166
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• 海关编码：
  2917399090

反应信息

• 作为反应物：
  描述：

  3,6-二硝基苯二甲酸 在 盐酸 、 tin 作用下， 生成 2,5-二氨基苯甲酸
  参考文献：
  名称：

  Improved morphology and crystalline quality of MBE CdZnTe/Si

  摘要：

  We report on continuing efforts to develop a reproducible process for molecular beam epitaxy of CdZnTe on three-inch, (211) Si wafers. Through a systematic study of growth parameters, we have significantly improved the crystalline quality and have reduced the density of typical surface defects. Lower substrate growth temperatures (similar to 250-280 degreesC) and higher CdZnTe growth rates improved the surface morphology of the epilayers by reducing the density of triangular surface defects. Cyclic thermal annealing was found to reduce the dislocation density. Epilayers were characterized using Nomarski microscopy, scanning electron microscopy, x-ray diffraction, defect-decoration etching, and by their use as substrates for HgCdTe epitaxy.

  DOI：

  10.1007/bf02665842
• 作为产物：
  描述：

  1,2,5,8-Tetranitro-naphthalin 在 sodium peroxide 作用下， 生成 3,6-二硝基苯二甲酸
  参考文献：
  名称：

  Will, Chemische Berichte, 1895, vol. 28, p. 372

  摘要：

  DOI：

文献信息

• Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs
  申请人：——

  公开号：US20030139451A1

  公开（公告）日：2003-07-24

  The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, nitrogen-substituted thalidomide analogs and di-substituted thalidomide analogs have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.

  本发明涵盖了一组有效抑制血管生成的化合物。更具体地说，已经证明氮取代苯酰胺类和二取代苯酰胺类硫酰胺类化合物能够抑制血管生成。重要的是，这些化合物可以经口服给药。
• NEW SUBSTANCE TREHALOSTATIN AND PRODUCTION THEREOF
  申请人：SUNTORY LIMITED

  公开号：EP0414914A1

  公开（公告）日：1991-03-06

  This invention relates to a new substance trehalostatin, a method of producing said substance, and an actinomycete producing said substance. Trehalostatin has the following physicochemical properties: form: white powder, solubility: soluble in water, and difficultly soluble in hexane, benzene, ether and petroleum ether, UV spectrum: no absorption maxima above 220 nm, color reaction: positive in Rydon-Smith reaction, and negative in ninhydrin reaction, 3,6-dinitrophthalate reaction and Elson-Morgan reaction, molecular weight:366 (m/z 367, M+H, according to SIMS),[α]D: +115°. Trehalostatin exhibits an inhibitory effect on insect, especially trehalose of Aldrichia grahami, even at an extremely low concentration and thus is useful as an insecticide.

  本发明涉及一种新物质特瑞沙司他丁（trehalostatin）、生产该物质的方法以及生产该物质的放线菌。特瑞沙司他丁具有以下理化性质：形态：白色粉末；溶解性：易溶于水，难溶于己烷、苯、乙醚和石油醚；紫外光谱：在 220 纳米以上无吸收峰值；颜色反应：在雷东-史密斯反应中为阳性，在茚三酮反应、3,6-二硝基邻苯二甲酸盐反应和埃尔森-摩根反应中为阴性；分子量：366（根据 SIMS，m/z 367，M+H）；[α]D：+115°。即使在浓度极低的情况下，曲哈司他丁也能对昆虫，尤其是对 Aldrichia grahami 的曲哈司他丁产生抑制作用，因此可用作杀虫剂。
• USE OF N-DESULFATED HEPARIN FOR TREATING OR PREVENTING INFLAMMATIONS
  申请人：Shanghai Institute of Cell Biology, Cas

  公开号：EP1300153A1

  公开（公告）日：2003-04-09

  The invention relates to the use of N-desulfated heparin for treating or preventing inflammation, which is based on the experimental results in animal acute abdominal inflammation model and animal bleed model. The N-desulfated heparin's anti-inflammation activity is better than or equal to that of the low molecular weight heparin, and has low activity of anti-coagulant. From a series of N-desulfated heparin of different N-sulfur-containing, a sample of the best anti-inflammation activity and the lowest anti-coagulant activity was selected. The invention solved the problem of bleeding in the use of heparin for treating of inflammation, and provided a new pathway to use heparin to prevent and treat inflammation.

  本发明涉及 N-去硫肝素在治疗或预防炎症方面的用途，其依据是动物急性腹部炎症模型和动物出血模型的实验结果。N-脱硫肝素的抗炎活性优于或等于低分子量肝素，抗凝活性较低。从一系列不同含 N-硫的 N-脱硫肝素中，筛选出抗炎活性最好、抗凝血活性最低的样品。本发明解决了使用肝素治疗炎症时的出血问题，为使用肝素预防和治疗炎症提供了新的途径。
• Use of n-desulfated heparin for treating or preventing inflammations
  申请人：——

  公开号：US20030147848A1

  公开（公告）日：2003-08-07

  The invention relates to the use of N-desulfated heparin for treating or preventing inflammation, which is based on the experimental results in animal acute abdominal inflammation model and animal bleed model. The N-desulfated heparin's anti-inflammation activity is better than or equal to that of the low molecular weight heparin, and has low activity of anti-coagulant. From a series of N-desulfated heparin of different N-sulfur-containing, a sample of the best anti-inflammation activity and the lowest anti-coagulant activity was selected. The invention solved the problem of bleeding in the use of heparin for treating of inflammation, and provided a new pathway to use heparin to prevent and treat inflammation.

  本发明涉及 N-去硫肝素在治疗或预防炎症方面的用途，其依据是动物急性腹部炎症模型和动物出血模型的实验结果。N-脱硫肝素的抗炎活性优于或等于低分子量肝素，抗凝活性较低。从一系列不同含 N-硫的 N-脱硫肝素中，筛选出抗炎活性最好、抗凝血活性最低的样品。本发明解决了使用肝素治疗炎症时的出血问题，为使用肝素预防和治疗炎症提供了新的途径。
• Enhancing protein thermostability
  申请人：——

  公开号：US20030166195A1

  公开（公告）日：2003-09-04

  A composition containing a thermolabile protein admixed with a liquor waste. Also disclosed is a method of preparing such a composition which contains a protein with enhanced thermostability.

  一种含有掺入废液中的耐热蛋白质的组合物。还公开了一种制备这种组合物的方法，其中含有一种热稳定性更强的蛋白质。