benzoyl phenylalanylvalylarginyl 7-amino, 4-methyl coumarin

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: benzoyl phenylalanylvalylarginyl 7-amino, 4-methyl coumarin
• 英文别名: Bz-Phe-Val-Arg-7-amino-4-methylcoumarin；benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin；Thrombin substrate III；BZ-Phe-val-arg-amc；N-[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]benzamide
• 化学式: C₃₇H₄₃N₇O₆
• 分子量: 681.792
• InChiKey: QBDRNGBZKAOZHF-OLWNVYNHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  50
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  207
• 氢给体数：
  6
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  Fmoc-Orn-7-amino-4-methylcoumarin 、 Fmoc-L-缬氨酸 、 Fmoc-L-苯丙氨酸 、 N,N′-二-Boc-硫脲 、 alkaline earth salt of/the/ methylsulfuric acid 以73%的产率得到benzoyl phenylalanylvalylarginyl 7-amino, 4-methyl coumarin
  参考文献：
  名称：

  A novel solid-phase linker strategy for the side-chain anchoring of arginine: an expeditious route to arginine 7-amido-4-methylcoumarins

  摘要：

  A novel linker strategy for the efficient side-chain anchoring of arginine is described. The utility of this approach was demonstrated by the facile synthesis of arginine-specific fluorogenic peptide substrates by standard Fmoc solid phase peptide synthesis methods. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.03.019

文献信息

• A novel solid-phase linker strategy for the side-chain anchoring of arginine: an expeditious route to arginine 7-amido-4-methylcoumarins
  作者：Joerg Beythien、Sophie Barthélémy、Peter Schneeberger、Peter D. White

  DOI：10.1016/j.tetlet.2006.03.019

  日期：2006.5

  A novel linker strategy for the efficient side-chain anchoring of arginine is described. The utility of this approach was demonstrated by the facile synthesis of arginine-specific fluorogenic peptide substrates by standard Fmoc solid phase peptide synthesis methods. (c) 2006 Elsevier Ltd. All rights reserved.